Metabolic mechanism of a polysaccharide from Schisandra chinensis to relieve chronic fatigue syndrome

Chi, Aiping; Yang, Zhou; Kang, Yijiang; Shen, Zhimei

doi:10.1016/j.ijbiomac.2016.08.042

Cited by 40 publications

(19 citation statements)

References 42 publications

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“…The molecular morphology of polysaccharide was related not only the polymeric degree of molecular but also its biological activity [29]. The previous research found that the surface topography of protein–polysaccharide conjugates usually appeared in a spherical, flocculent, or sheet structure with a diameter of 0.5–10 μm [14,30,31]. The molecular morphology of Se-TP showed many spherical particles with a diameter of 5 μm, but its surface was very smooth.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome

et al. 2018

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Ziyang green tea was considered a medicine food homology plant to improve chronic fatigue Ssyndrome (CFS) in China. The aim of this research was to study the therapeutic effect of selenium-polysaccharides (Se-TP) from Ziyang green tea on CFS and explore its metabolic mechanism. A CFS-rats model was established in the present research and Se-TP was administrated to evaluate the therapeutic effect on CFS. Some serum metabolites including blood urea nitrogen (BUN), blood lactate acid (BLA), corticosterone (CORT), and aldosterone (ALD) were checked. Urine metabolites were analyzed via gas chromatography-mass spectrometry (GC-MS). Multivariate statistical analysis was also used to check the data. The results selected biomarkers that were entered into the MetPA database to analyze their corresponding metabolic pathways. The results demonstrated that Se-TP markedly improved the level of BUN and CORT in CFS rats. A total of eight differential metabolites were detected in GC-MS analysis, which were benzoic acid, itaconic acid, glutaric acid, 4-acetamidobutyric acid, creatine, 2-hydroxy-3-isopropylbutanedioic acid, l-dopa, and 21-hydroxypregnenolone. These differential metabolites were entered into the MetPA database to search for the corresponding metabolic pathways and three related metabolic pathways were screened out. The first pathway was steroid hormone biosynthesis. The second was tyrosine metabolism, and the third was arginine-proline metabolism. The 21-hydroxypregnenolone level of rats in the CFS group markedly increased after the Se-TP administration. In conclusion, Se-TP treatments on CFS rats improved their condition. Its metabolic mechanism was closely related to that which regulates the steroid hormone biosynthesis.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome

et al. 2018

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“…Scatters of different shapes and colors represent different sample groups. As can be seen from the two figures, there were systematic differences in metabolites between the normal group and the model group, and between the model group and EI30 high-dose group, indicating that first the PCPA induced insomnia mice model was successfully made, and EI30 had obvious effects on the model [38]. Compared with the results of PCA, the OPLS-DA model showed the differences between sample groups more clearly.…”

Section: Results Of Opls-damentioning

confidence: 87%

Revealing the sedative-hypnotic effect of the extracts of herb pair Semen Ziziphi spinosae and Radix Polygalae and related mechanisms through experiments and metabolomics approach

Luo

Sun

Wang

et al. 2020

BMC Complement Med Ther

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Background: Semen Ziziphi spinosae and Radix Polygalae, two herbs commonly used together in Traditional Chinese Medicine for the treatment of insomnia and anxiety. The study aims to study the sedative-hypnotic effect of the active components of the herbal pair, the possible mechanisms of such effect, and related metabolic pathways in vivo. Methods: The sedative and hypnotic effect of the active components (EI30) of the herbal pair was studied by recording influence on the proportion of sleeping within 30 min, sleep latency and sleep length of pentobarbital sodium-induced sleeping on mice. Possible mechanisms of the sedative-hypnotic effect of the active components were investigated by measuring the content of neurotransmitters in the total protein of mice brain tissue. The main chemical compounds of the herbal pair were identified by Liquid Chromatography-Mass Spectrometry (LC-MS). Serum samples of mice were studied, and related differential metabolites between the normal group and model group, and between model group and treatment group were identified by Gas Chromatography Time-Of-Flight Mass Spectrometry (GC-TOF-MS), Principal Components Analysis (PCA), and Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA).

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“… 13 A metabolic mechanism of a polysaccharide from Schisandra to relieve chronic fatigue syndrome has been reported. 14 Alternatively, α-cubebenoate may act as an antifatigue constituent of Schisandra through anti-inflammation, and could be of therapeutic use as a treatment for inflammatory diseases such as cancer. 15 …”

Section: Discussionmentioning

confidence: 99%

“…11 NYT includes constituents that relieve the fatigue caused by chemotherapy. 12 , 13 , 14 , 15 Among patients who receive nab-paclitaxel plus gemcitabine therapy, QOL is often impaired by fatigue and peripheral neuropathy. Balancing subjective and objective assessment of these symptoms is difficult in clinical settings.…”

Section: Introductionmentioning

confidence: 99%

Impact of Ninjin'Yoeito on Fatigue in Patients Receiving Nab-Paclitaxel Plus Gemcitabine Therapy: A Prospective, Single-Arm, Phase II Open Label, Nonrandomized, Historically-Controlled Study

Okada

Kawai

Hirono

et al. 2020

Current Therapeutic Research

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Background Ninjin'yoeito , a traditional Japanese herbal medicine, is used to prevent fatigue, loss of appetite, and coldness of limbs. Fatigue is an especially common issue during chemotherapy and can affect quality of life and the ability to complete scheduled treatment. Objectives This prospective exploratory trial evaluates the efficacy of ninjin'yoeito for fatigue in patients undergoing nab-paclitaxel plus gemcitabine therapy for unresectable pancreatic cancer. The primary end point was evaluation of fatigue according to Functional Assessment of Chronic Illness Therapy-Fatigue score during 2 courses of nab-paclitaxel plus gemcitabine therapy. Secondary end points included evaluation of dose intensity, appetite loss using numerical rating scale, and peripheral neuropathy using a patient neurotoxicity questionnaire. Methods We compared data from this interventional trial with a prior observational trial without administration of ninjin'yoeito with identical definition of end points (UMIN000021758). Thirty patients were required by the study. Results Threshold mean of Functional Assessment of Chronic Illness Therapy-Fatigue score across 8 weeks during chemotherapy was under 5.3 ( P = 0.002). Secondary end points did not reveal any specific patterns in appetite loss or degree of pain. No significant changes in patient neurotoxicity questionnaire concerning sensory/motor disorders were observed, but the mean (SD) incidence of patients with sensory disturbance was higher between the fifth and eighth weeks (8.8 [1.26]) than during the first and fourth weeks (4.8 [0.96]) ( P = 0.003). Clinically significant adverse reactions of ninjin'yoeito were not observed. Conclusions Ninjin'yoeito may be useful for improving the symptoms of fatigue caused by nab-paclitaxel plus gemcitabine in patients with unresectable pancreatic cancer. UMIN Clinical Trials Registry identifier: UMIN000025606. ( Curr Ther Res Clin Exp . 2020; 81:XXX–XXX)

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Metabolic mechanism of a polysaccharide from Schisandra chinensis to relieve chronic fatigue syndrome

Cited by 40 publications

References 42 publications

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome

Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome

Revealing the sedative-hypnotic effect of the extracts of herb pair Semen Ziziphi spinosae and Radix Polygalae and related mechanisms through experiments and metabolomics approach

Impact of Ninjin'Yoeito on Fatigue in Patients Receiving Nab-Paclitaxel Plus Gemcitabine Therapy: A Prospective, Single-Arm, Phase II Open Label, Nonrandomized, Historically-Controlled Study

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