Metabolic Markers of Cobalamin Deficiency and Cognitive Function in Normal Older Adults

Abstract

This study indicates that, in normal elderly subjects, some cognitive scores are related to serum methylcitric acid and possibly homocysteine.

Vitamin B12 Intake Correlated to Physical and Mental Improvements in Multiple Sclerosis Specific Quality of Life

“…Vitamin B 12 is also known to potentially have a role in the maintenance of neurophysiological health, cognitive health, and function [28][29][30][31]. Existing literature is clear; vitamin B 12 can positively affect mental health and physical functioning, which is concurrent with the results presented here, and further supports the importance of vitamin B 12 for normal physiological functioning and QOL [32][33][34][35]. Current dietary recommendations for individuals with MS may be too simplistic or general for this complex disease.…”

Biochemical indicators of vitamin B 12 and folate insufficiency and cognitive decline

“…In the longest trial (3 years), a large sample and a single vitamin intervention (800 g folic acid daily), folate supplements significantly improved memory, information processing speed, and sensorimotor speed among Dutch adults. 34 Although some cross-sectional evidence exists for a methylmalonic acid and cognition association, 30,[37][38][39][40] to our knowledge, there is limited study of its relation to cognitive decline. In the Oxford Healthy Aging Project, greater cognitive decline (over 10 years) was associated with lower holotranscobalamin and higher methylmalonic acid concentrations after adjustment for a number of vitamin markers.…”

Executive dysfunction in hyperhomocystinemia responds to homocysteine-lowering treatment

“…Even in nondemented elderly subjects, tHcy levels are strongly correlated with frontal/executive function, 7 and frontal/executive impairment increases the risk of progression to dementia. 8 As frontal/executive function is often related to the degree of periventricular white matter damage, 9 and the degree of white matter damage is correlated with tHcy levels, 2 tHcy may be an important mediator of executive dysfunction in subjects with cognitive impairment.…”