Biochemical indicators of vitamin B
            <sub>12</sub>
            and folate insufficiency and cognitive decline

Tangney, Christine C.; Tang, Yuxiao; Evans, Denis A.; Morris, Martha Clare

doi:10.1212/01.wnl.0000341272.48617.b0

Cited by 113 publications

(87 citation statements)

References 42 publications

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“…Thus, some of the inconsistent findings across studies of B-vitamin effects on cognitive decline and dementia may be due to the range of nutrient status in the study population. Of ten cohort studies that examined the relations of these B-vitamins and cognitive decline, four reported protective associations with folate (164)(165)(166)(167) and three reported protective associations with vitamin B 12 (165,(168)(169)(170) but many found no association with one or the other Bvitamin (165,(170)(171)(172)(173)(174) . The Chicago Health and Ageing Project study found a deleterious effect of faster decline among persons with food and/or supplement intakes exceeding 400 mg/d (6) .…”

Section: B-vitamins Cognitive Decline and Alzheimer's Diseasementioning

confidence: 99%

Nutritional determinants of cognitive aging and dementia

2011

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The objective of this review is to provide an overview of nutritional factors involved in cognitive aging and dementia with a focus on nutrients that are also important in neurocognitive development. Several dietary components were targeted, including antioxidant nutrients, dietary fats and B-vitamins. A critical review of the literature on each nutrient group is presented, beginning with laboratory and animal studies of the underlying biological mechanisms, followed by prospective epidemiological studies and randomised clinical trials. The evidence to date is fairly strong for protective associations of vitamin E from food sources, the n-3 fatty acid, DHA, found in fish, a high ratio of polyunsaturated to saturated fats, and vitamin B 12 and folate. Attention to the level of nutrient intake is crucial for interpreting the literature and the inconsistencies across studies. Most of the epidemiological studies that observe associations have sufficient numbers of individuals who have both low and adequate nutrient status. Few of the randomised clinical trials are designed to target participants who have low baseline status before randomising to vitamin supplement treatments, and this may have resulted in negative findings. Post-hoc analyses by some of the trials reveal vitamin effects in individuals with low baseline intakes. The field of diet and dementia is a relatively young area of study. Much further work needs to be done to understand dietary determinants of cognitive aging and diseases. Further, these studies must be particularly focused on the levels of nutrient intake or status that confer optimum or suboptimal brain functioning. Nutrition: Cognitive decline: Dementia: Antioxidant nutrients: Dietary fatsAfter more than a decade of research on nutrition and the aging brain, a number of promising nutritional factors have emerged that are also important to neurocognitive development. This review describes the evidence for these nutritional factors that show the most promise in the prevention of neurodegenerative disease. Among these are antioxidant nutrients, B-vitamins, dietary fat composition and n-3 fatty acids. Each of these factors has a body of literature to support underlying biological mechanisms for association as well as evidence of association from prospective epidemiological studies. The clinical trial evidence for vitamin supplements has been disappointing, but very few of these trials were designed to test whether supplementation is effective in persons who have low nutrient status for that particular dietary component.In general, potential recommendations to maintain a healthy brain reflect those that have been demonstrated to maintain a healthy heart: physical activity combined with a diet that has a high ratio of unsaturated to saturated fats, vegetables, fruits and fish. In this review, we first describe common neurodegenerative diseases of aging and some basic fundamentals in nutrient absorption and physiological function. These sections are followed by a review of the evidence for each die...

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Section: B-vitamins Cognitive Decline and Alzheimer's Diseasementioning

confidence: 99%

Nutritional determinants of cognitive aging and dementia

2011

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“…A higher educational level and higher engagement in physical, cognitive and social activities are lifestyle factors that may reduce the risk of dementia or cognitive decline (Hamer and Chida 2009;Kareholt et al 2011;Morgan et al 2012;Niti et al 2008;Sattler et al 2012). Nutritional epidemiology has examined the potential benefit on cognition of fatty acids (van Gelder et al 2007), vitamins (Mangialasche et al 2010;Tangney et al 2009), fish (van Gelder et al 2007), fruit and vegetables (Hughes et al 2010) with favorable but not fully consistent results. Thus, both genetic and lifestyle-related factors are involved in cognitive decline and dementia, but these factors do not contribute independently to neurodegeneration.…”

Section: Introductionmentioning

confidence: 99%

Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial

et al. 2014

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The traditional Mediterranean diet (MedDiet) has shown beneficial effects on cognitive decline. Nevertheless, diet-gene interactions have been poorly evaluated. We aimed to investigate diet-gene interaction in the PREDIMED-NAVARRA randomized trial. A total of 522 participants (67 ± 6 years at baseline) enrolled in the PREDIMED-NAVARRA trial were randomly allocated to one of three diets: two MedDiets (supplemented with either extra-virgin olive oil or nuts) or a low-fat diet. They were evaluated with the Mini-Mental State Examination (MMSE) and the Clock Drawing Test (CDT) after 6.5 years of intervention. Subjects were genotyped for CR1-rs3818361, CLU-rs11136000, PICALM-rs3851179 and Apolipoprotein E (ApoE) genes. We studied MedDietgene interactions for cognition and assessed the effect of the MedDiet on cognition across different genetic profiles. A significant interaction (p = 0.041) between CLUrs11136000 and the MedDiet intervention on the MMSE was found with a beneficial effect of MedDiet among carriers of the T minor allele (B = 0.97, 95 % CI 0.45-1.49). Similar effect was observed for CR1-rs3818361, but no significant interaction was observed (p = 0.335). For PICALM-rs3851179, the MedDiet intervention showed a beneficial effect in both genotype groups. No apparent interaction was found for the CDT between intervention and gene variants. Similarly, participants randomly allocated to MedDiet groups, with favorable 123Genes Nutr (2014) 9:393 DOI 10.1007/s12263-014-0393-7 profiles of CR1, CLU and PICALM genes, significantly improved CDT scores compared to controls with the same genetic profile. Cognitive performance was better for nonApoE4 and for ApoE4 carriers of MedDiet groups compared to controls, but for CDT performance, we only found statistical significant differences for non-ApoE4 carriers. A MedDiet intervention modulates the effect of genetic factors on cognition. The effect of MedDiet might be greater for subjects with a more favorable genetic profile.

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“…Folic acid deficiencies lead the development depression and slow down the response to antidepressant medication [23,24]. In some cases the first clinical manifestation of vitamin B12 deficiency is a psychiatric disorder and relatively common in old age in which mostly associated with cognitive impairments [25][26][27].…”

Section: Effect Of Micronutrient On Depressionmentioning

confidence: 99%

The Role of Micronutrient for Depressed Patients

Demelash¹

2017

J Neuropsychopharmacol Mental Health

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Majority of people are not aware of the relation between nutrition and depression. Depression is mostly resulted from an imbalance in brain chemical that can be due to more typically thought of as strictly biochemical-based or emotionally-rooted. As a result, nutrition can play a key role in the onset as well as severity and duration of depression. Several micronutrient deficiencies adversely affect the brain and hence could aggravate mental disorders. It is important that proper attention to diet, and, when indicated, appropriate supplementation with vitamin C, folic acid, niacin, thiamine, iron, zinc, magnesium , potassium and sodium and omega-3 fatty acids. As the brain chemical (neurotransmitters) are made from chemical precursors, usually from an amino acid (protein) and other micronutrients (vitamin and minerals), it is clear to understand how deficiencies of these nutrients could lead to changes in the pattern of brain chemical neurotransmitter production leading to mental illness like depression.

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Biochemical indicators of vitamin B ₁₂ and folate insufficiency and cognitive decline

Abstract: Background:In some prospective studies, associations of serum vitamin B 12 and homocysteine

Cited by 113 publications

References 42 publications

Nutritional determinants of cognitive aging and dementia

Nutritional determinants of cognitive aging and dementia

Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial

The Role of Micronutrient for Depressed Patients

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Biochemical indicators of vitamin B 12 and folate insufficiency and cognitive decline

Abstract: Background:In some prospective studies, associations of serum vitamin B 12 and homocysteine

Cited by 113 publications

References 42 publications

Nutritional determinants of cognitive aging and dementia

Nutritional determinants of cognitive aging and dementia

Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial

The Role of Micronutrient for Depressed Patients

Contact Info

Product

Resources

About

Biochemical indicators of vitamin B ₁₂ and folate insufficiency and cognitive decline