Metabolic labelling of cancer cells with glycodendrimers stimulate immune-mediated cytotoxicity

Abstract

Combining glycometabolism and bio-orthogonal chemistry to label cells with antigenic glycodendrimers lead to the activation of immune response against cancer cells.

Multivalent glycocyclopeptides: conjugation methods and biological applications

“…In another approach, 152 the best ABM 136 ( Fig. 11 ) was conjugated to the glycocalyx of BT-549 cancer cells by means of a metabolic labelling strategy using copper-free strain-promoted azide-alkyne cycloaddition.…”

Synthesis and anticancer properties of dendritic glycoconjugates containing multiple o-carborane clusters

“…The yield of the products refers to analytically pure samples. 1 H and 13 C NMR spectra were recorded on a Fourier Transform multinuclear NMR spectrometer at 400 MHz and 100 MHz respectively. Chemical shifts were reported relative to TMS ( 1 H: d = 0.00 ppm), CDCl 3 ( 13 C: d = 77.0 ppm) and coupling constants are given in Hz.…”

“…Chemical shifts were reported relative to TMS ( 1 H: d = 0.00 ppm), CDCl 3 ( 13 C: d = 77.0 ppm) and coupling constants are given in Hz. All 13 C spectra are proton-decoupled. 11 B NMR spectra are proton-decoupled and were recorded at 128 MHz relative to BF 3 ÁEt 2 O.…”

“…MP: 4250 1C. 1 H NMR (400 MHz, CDCl 3 , d ppm): 7.52 (s, 3H, Ar-H), 7.50 (d, 6H, J = 8 Hz, Ar-H), 7.39 (d, 6H, J = 4 Hz, Ar-H), 7.37 (d, 6H, J = 4 Hz, Ar-H), 6.63 (d, 6H, J = 8 Hz, Ar-H), 3.69 (s, 9H, OCH 3 -H); 13 Compound 7. BBr 3 (2.8 mL, 2.8 mmol, 1 M in CH 2 Cl 2 , 10.5 equiv.)…”

“…12 Glycodendrimers have been used as selective delivery agents for cancer cells. 13 We reported dendritic glycoconjugates containing one o -carborane moiety and evaluated anticancer efficacy in vitro against two cancer cell lines (MCF-7 and A-431) and one normal skin epidermal cell line (HaCaT). The results of the study revealed that the synthesized compounds were less toxic towards HaCaT normal cell lines while more cytotoxic towards cancer cells.…”