Metabolic factors accelerate colorectal adenoma recurrence

Taniguchi, Leo; Higurashi, Takuma; Uchiyama, Takashi; Kondo, Yoshinobu; Uchida, Etsuo; Uchiyama, S.; Jono, Fumitake; Hamanaka, Jun; Kuriyama, Hitoshi; Hata, Yasuo; Endo, Hideki; Takahashi, Hirokazu; Nagase, Hajime; Matsuhashi, Nobuyuki; Nakajima, Atsushi

doi:10.1186/1471-230x-14-187

Cited by 21 publications

(21 citation statements)

References 27 publications

(37 reference statements)

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“…reports showing that age is a risk factor for the prevalence of colorectal adenoma 19,20 and that the recurrence increased among older patients on the follow-up colonoscopy after endoscopic removal of adenoma, 21,22 we can presume a similar mechanism for a possible increase in local recurrence.…”

Section: Discussionmentioning

confidence: 83%

Local Recurrence and Its Risk Factor after Incomplete Resection of Colorectal Advanced Adenomas: A Single Center, Retrospective Study

Lee

Kim

et al. 2017

Korean J Gastroenterol

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Background/Aims: Colonoscopy can detect precancerous lesions, which can subsequently be removed and reduce incidences of and mortality from colorectal cancer (CRC). However, recently published data have highlighted a significant rate of CRC in patients who previously underwent colonoscopy. Among many reasons, incomplete resection has been considered as a significant contributor. However, to date, there have only been a few studies regarding incompletely resected polyps, especially advanced colorectal adenoma (ACA). Hence, we aimed to evaluate the prognosis of incompletely resected ACA. Methods: We retrospectively reviewed the medical records of patients with ACA who had underwent endoscopic treatment with incomplete resection. The primary outcomes were (1) the incomplete resection rate of ACA, as determined by a histopathologic examination and (2) the recurrence rate of incompletely resected ACA. We also investigated the probable contributing factors that may have led to a relapse of incompletely resected ACA. Results: A total of 7,105 patients had their colorectal polyps resected by endoscopic treatment, and 2,233 of these were considered as ACA. Of these, 354 polyps (15.8%) were resected incompletely, and only 163 patients were followed-up. Of those followed-up, 31 patients (19.0%) experienced local recurrence. The risk factors for recurrence after incomplete resection were evaluated; age, morphology of adenoma, and use of rescue therapy, such as argon plasma coagulation, were found to be associated with adenoma recurrence. Conclusions: Incompletely resected ACA in older patients or in patients with sessile-type adenomas should be monitored strictly, and if incomplete resection is suspected, rescue therapy must be considered. (Korean J Gastroenterol 2017;70:33-38)

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Section: Discussionmentioning

confidence: 83%

Local Recurrence and Its Risk Factor after Incomplete Resection of Colorectal Advanced Adenomas: A Single Center, Retrospective Study

Lee

Kim

et al. 2017

Korean J Gastroenterol

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“…No studies were found on the relation between the GV and response to treatment in individuals with cancer. Despite that, the influence of glucose levels (13,14), insulin levels (6,13,15), presence of diabetes mellitus (16) and metabolic syndrome presence (5,17) are already related to the increased risk of CRC development (6,13,16) and impact the prognosis of those patients (5,14,16,17).…”

Section: Discussionmentioning

confidence: 99%

Glucose variations and their impact on the treatment response in advanced colorectal cancer

Sarraf¹,

Puty²,

Brito³

et al. 2017

Scripta Scientifica Vox Studentium

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INTRODUCTION: Serum glucose is commonly associated with a bad clinical prognosis in many diseases, including colorectal cancer (CRC). However, the real impact of glucose variation (GV) on the treatment and prognosis of CRC patients is unknown. Due to the absence of information, this study aimed to correlate GV and treatment response in advanced CRC. MATERIALS AND METHODS: Thirty-eight CRC patients with stage III and IV disease were studied. The selected ones were those who have had two consecutive computed-tomography scans and more than one serum glucose (SG) test between the CT scans, which left 19 people of the original group. RESULTS: The mean age of the 19 analyzed subjects was 58.6 years SD=18.26; CI 95% 50.9-71.0. Most of the patients were men (59%), with Wilt-Type KRAS mutation (63.2%), without metastasis (71%) and at a clinical stage III (73.3%). No statistically significant value was found (p=0.126) between GV and treatment response in advanced CRC patients. CONCLUSION: These findings cannot indicate a direct association between GV and treatment response in advanced CRC patient, but open space for evaluation of new methods of handling glucose variations in attempt to get a better understanding about how glucose may influence the CRC prognosis.

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“…Researchers have found that obesity promotes the expression of insulin and insulin-like growth factor-1 (IGF-1), causing the transformation of non-advanced colorectal polyps to advanced polyps and triggering recurrence [13]. Several recent studies have shown that metabolic syndrome is associated with an increased risk of recurrent colorectal adenoma [14,15]. Metabolic factors (age, BMI, and fasting blood glucose) signi cantly accelerate the development of recurrence after removal of adenomas [15].…”

Section: Introductionmentioning

confidence: 99%

Elevated serum triglyceride predicts recurrence of colorectal polyps in patients with advanced adenomas

Liu

Wen

et al. 2020

Preprint

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Background: Recurrence of colorectal polyps is common and impacted by various factors. This study was performed to explore the association between lipid profiles and recurrence of colorectal polyps.Methods: This study retrospectively analyzed the lipid profiles of 435 patients who underwent colonoscopy with removal of colorectal polyps and assessed recurrence of polyps by follow-up colonoscopy. Multivariate regression logistic analysis was used to evaluate the association between lipid profiles and polyp recurrence.Results: During the 1.5-year follow-up, recurrence of colorectal polyps was observed in 135 of 435 patients (30.34%). Patients with recurrent polyps showed a higher level of triglycerides (P = 0.006) and lower levels of high-density lipoprotein cholesterol (P = 0.008) and apolipoprotein A1 (P = 0.033). The multivariate regression logistic model suggested that an elevated triglyceride level was an independent risk factor for polyp recurrence (odds ratio, 1.55; 95% confidence interval, 1.02 - 2.35; P = 0.039) in patients with advanced adenoma.Conclusions: Lipid profiles are associated with recurrence of colorectal polyps. An elevated triglyceride level is an independent risk predictor of polyp recurrence in patients with advanced adenoma.

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Metabolic factors accelerate colorectal adenoma recurrence

Cited by 21 publications

References 27 publications

Local Recurrence and Its Risk Factor after Incomplete Resection of Colorectal Advanced Adenomas: A Single Center, Retrospective Study

Local Recurrence and Its Risk Factor after Incomplete Resection of Colorectal Advanced Adenomas: A Single Center, Retrospective Study

Glucose variations and their impact on the treatment response in advanced colorectal cancer

Elevated serum triglyceride predicts recurrence of colorectal polyps in patients with advanced adenomas

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