Elevated serum triglyceride predicts recurrence of colorectal polyps in patients with advanced adenomas

Abstract

Background: Recurrence of colorectal polyps is common and impacted by various factors. This study was performed to explore the association between lipid profiles and recurrence of colorectal polyps.Methods: This study retrospectively analyzed the lipid profiles of 435 patients who underwent colonoscopy with removal of colorectal polyps and assessed recurrence of polyps by follow-up colonoscopy. Multivariate regression logistic analysis was used to evaluate the association between lipid profiles and polyp recurrence.Results: During the 1.5-year follow-up, recurrence of colorectal polyps was observed in 135 of 435 patients (30.34%). Patients with recurrent polyps showed a higher level of triglycerides (P = 0.006) and lower levels of high-density lipoprotein cholesterol (P = 0.008) and apolipoprotein A1 (P = 0.033). The multivariate regression logistic model suggested that an elevated triglyceride level was an independent risk factor for polyp recurrence (odds ratio, 1.55; 95% confidence interval, 1.02 - 2.35; P = 0.039) in patients with advanced adenoma.Conclusions: Lipid profiles are associated with recurrence of colorectal polyps. An elevated triglyceride level is an independent risk predictor of polyp recurrence in patients with advanced adenoma.

High Levels Of Triglycerides And Apolipoprotein B Increase The Risk Of Colorectal Polyp Recurrence After Endoscopic Resection

“…Another mechanism is that dyslipidemia creates a tumorigenic environment by increasing levels of interleukin-6, tumor necrosis factor-α, and other in ammatory cytokines 33 . Finally, Boying Liu et al suggested that TG may affect polyp recurrence by increasing the proliferative capacity of cancer stem cells or stimulating signaling pathways that promote cell invasion 13 .…”

“…Identifying non-invasive markers of polyp recurrence risk could help identify at-risk patients. Elevated triglyceride levels in serum are an independent risk factor for polyp recurrence in patients with advanced adenomas 13 . Long-term lipid stimulation suppresses anti-tumor immune responses, facilitating colorectal tumorigenesis and distant metastasis, and suppresses immune in ltrating cell function in the tumor microenvironment, thereby accelerating tumor progression 14 .…”

Association between serum lipid profiles and colorectal adenoma in Chinese population

“…The serum lipid pro les were examined using commercial kits following manufacture's instruction as previously described [19]. Fasting blood sample was collected from each participant within 24 hour after admission.…”