[Metabolic effects of Ramadan fasting on type 2 diabetes]

Abstract

Nous avons analysé les effets métaboliques, en particulier les variations du cholestérol HDL, du jeûne du mois de ramadan chez 25 diabétiques de type 2 bien équilibrés traités par le régime ou les antidiabétiques oraux. Nos patients ont été évalués trois semaines avant le ramadan, durant la quatrième semaine du mois de ramadan et trois semaines aprés le mois de ramadan. Cette évaluation a comporté une enquête clinique, une enquête nutritionnelle et des analyses biologiques. Le jeûne du mois de ramadan n’a pas eu d’influence sur le poids, la tension artérielle, la glycémie, la fructosamine et l’hémoglobine A1c. Nous avons trouvé une relation négative entre les variations du cholestérol HDL et la consommation alimentaire de cholestérol. Le cholestérol HDL a augmenté de 13 % à la fin du jeûne et de 23 % trois semaines après la fin du jeûne chez les diabétiques ayant eu une consommation alimentaire de cholestérol inférieure à 400 mg/j

Biochemical, physiological and body composition changes in patients with type 2 diabetes during Ramadan fasting

“…Several studies did not find any significant difference in weight, BMI, and body fat percentage before and during Ramadan. [3,4] Indeed, in 2003 Bouguerra et al [5] surveyed 25 well-controlled patients with T2DM treated with diet or oral antidiabetic agents. Weight and body mass index (BMI) remained stable during fasting and 3 weeks after completion of fasting.…”

Evaluation of Dry Fasting Effect during Ramadan on Protein Glycation in Saudi Individuals

“…High HbA1c levels in obesity and smoking can be used as a screening tool to detect insulin sensitivity and resistance at an early stage. Sayej, W. N et al had reported that reactive glycation products are present in aqueous extracts of tobacco and in tobacco smoke in a form that can rapidly react with proteins to form AGEs [20]. Frati, AC et al found that compared to non-smokers, smokers had significantly higher levels of fasting glucose, fasting insulin and HOMA-IR, this suggest that, smokers have a high risk of developing an insulin resistance and insulinemia, compared with a matched group of non-smokers [21].…”

Ramadan Fasting and NCDs-Example of the Diabetes

“…Also, an improvement in the lipid profile ( 53 , 56 , 57 ) was found, a significant decrease in fasting blood glucose during Ramadan compared to outside ( 53 , 57 , 58 ), hyperglycaemic episodes with or without ketoacidosis and severe hypoglycaemia ( 59 – 61 ), the presence of higher hypoglycemia in patients treated with insulin ( p = 0.002), followed by those treated with oral agents including sulfonylureas as compared to oral agents excluding sulfonylureas ( 57 ). Also saved, a non-significant reduction in plasma creatinine, uric acid ( 53 ), an improvement in blood pressure figures ( 57 ), while in another study no change was found ( 6 , 56 ).…”

“…As for the effect of Ramadan fasting on the body composition of the diabetic patient, the results were discordant. The researchers Aloulou et al (36), Khaled and Belbraouet (7), and McEwen et al (37) reported changes, in other studies some changes were found (16,38,39) and for others no change was found (6,21,(40)(41)(42)(43).…”

“…Despite this, many diabetics fast despite the risk of complications and decompensation ( 2 ). Indeed, in the literature, several studies have been interested in fasting Ramadan related to diabetes as NCDs, and various works have been published on this subject around the world: in Lebanon ( 3 ), in Morocco ( 4 ), in France ( 5 ), in Tunisia ( 6 ), in Algeria ( 7 , 8 ). The interest of this theme also lies in the fact that there are many millions of Muslims in the world and the proportion of people with diabetes who are diagnosed or not.…”