Metabolic effects of intravenous salbutamol in the course of acute severe asthma.

Nogrady, S G; Hartley, J P; Seaton, Anthony

doi:10.1136/thx.32.5.559

Cited by 44 publications

(9 citation statements)

References 11 publications

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“…The increase in asthma deaths in the 1960s was attributed to the administration of high dose isoprenaline by inhaler (Stolley, 1972) but one explanation for the more recent increase in deaths noted in New Zealand is the combination of oral theophylline with 32-adrenoceptor stimulants (Wilson et al, 1981). Both salbutamol and terbutaline have been shown to have significant haemodynamic effects and to increase blood glucose and lower serum potassium even when inhaled (Leitch et al, 1976;Nogrady et al, 1977;Phillips et al, 1980;Kendall et al, 1982;Smith et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Potentiation of the adverse effects of intravenous terbutaline by oral theophylline.

Smith¹,

Kendall²

1986

Brit J Clinical Pharma

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We have studied the influence of therapeutic plasma concentrations of theophylline on some of the unwanted responses to intravenous terbutaline in normal subjects. There was a significantly greater fall in serum potassium and rise in plasma glucose, pulse rate and systolic blood pressure in response to an intravenous infusion of terbutaline when theophylline was present compared with when terbutaline was given alone. These drugs are commonly used together in the treatment of acute asthma and potentiation of side effects may be hazardous. We suggest monitoring of the serum potassium when these drugs are used together during acute exacerbations of asthma.

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Section: Introductionmentioning

confidence: 99%

Potentiation of the adverse effects of intravenous terbutaline by oral theophylline.

Smith¹,

Kendall²

1986

Brit J Clinical Pharma

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“…A significant increase in plasma insulin levels undoubt- edly occurs following the administration of intrave nous salbutamol to asthmatic patients [19][20][21]. In ad dition, it has been suggested that the plasma insulin response to epinephrine shows no 'gross abnormality' in asthma [4], However, none of these studies com pared the insulin responses of asthmatic and non asthmatic individuals.…”

Section: Discussionmentioning

confidence: 82%

Metabolic and Hormonal Responses to Salbutamol in Asthma. Evidence of Beta-Adrenergic Overactivity?

Kallenbach

Panz²,

Jankelow³

et al. 1990

Respiration

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The possibility that β-adrenergic hyposensitivity may be involved in the pathogenesis of bronchial asthma remains a controversial issue. The hormonal, metabolic and cardiovascular responses to selective β₂-adrenergic stimulation with salbutamol were compared in 11 asthmatic and 11 non-asthmatic subjects. There was no consistent difference between the two groups in the plasma free fatty acid, glucose and potassium responses, or in the cardiovascular variables studied, but the asthmatic patients demonstrated a marked dose-dependent hyperinsulinaemic response to salbutamol. Although this phenomenon cannot be accounted for with certainty, it may be a manifestation of pancreatic β-adrenergic overactivity which would not be in keeping with the concept of generalised hyposensitivity of β-adrenergic mechanisms in asthma. The present results provide a clear demonstration of the difficulties involved in attempts to relate extrapulmonary autonomic phenomena to the pathogenesis of bronchial asthma

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“…As β 2 -agonist also cause increase level of catecholamine, so it results in increase in blood glucose and FFA level 26,27 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2013

IJPSR

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ABSTRACT:Background: β2-agonist drugs are frequently prescribed in asthmatics. Apart from bronchodilation they affect biochemical and physical parameters of the body. Method: Total 80 patients were divided into two groups. Group I (n=40) received Albuterol-2.5mg./2.5ml. TDS and Group II (n=40) received Levalbuterol-0.63mg./2.5ml, TDS via nebulizer for 4 weeks. Baseline and post-treatment estimation of biochemical parameters including, fasting and postprandial plasma glucose levels, serum Na+, serum K+ levels, lipid profile, Monitoring of systolic and diastolic BP and adverse drug effects evaluation were carried out. Results: Significantly changes were in serum lipid profile and blood glucose in both the groups but increase was more in group I. Serum K+ level was decreased significantly (p<0.05) in both groups but decrease was more in group I patients. The fasting and postprandial plasma glucose levels were significantly increased in both the groups but increase was more in group I. Systolic BP increases and diastolic BP decreases after administration of both drugs. There was no significant change observed in Serum Na+ level after administration of both drugs. After administration of both the drugs, an increase was observed in serum Lipid profile level. Adverse drug profile showed that Levalbuterol produce less adverse effects as compare to Albuterol. Conclusion: This study concludes that Levalbuterol is safer and it carries fewer incidences of adverse effects as compare to Albuterol.

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Metabolic effects of intravenous salbutamol in the course of acute severe asthma.

Cited by 44 publications

References 11 publications

Potentiation of the adverse effects of intravenous terbutaline by oral theophylline.

Potentiation of the adverse effects of intravenous terbutaline by oral theophylline.

Metabolic and Hormonal Responses to Salbutamol in Asthma. Evidence of Beta-Adrenergic Overactivity?

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