Metabolic effects of duodenojejunal bypass surgery in a rat model of type 1 diabetes

Vangoitsenhoven, Roman; Wilson, Rickesha; Sharma, Gautam; Punchai, Suriya; Corcelles, Ricard; Froylich, Dvir; Mulya, Anny; Schauer, Philip R.; Brethauer, Stacy A.; Kirwan, John P.; Sangwan, Naseer; Brown, J. Mark; Aminian, Ali

doi:10.1007/s00464-020-07741-y

Cited by 1 publication

(1 citation statement)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regardless of the method of BS, the gastrointestinal system will be affected, followed by changes of microbial community in the stomach and gut [4]. Several studies have evaluated the relations between gut microbiota changes after BS [5][6][7][8]. Animal and anthropological studies have reported the gut microbial changes after SG [9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

The Genus Parabacteroides Is a Potential Contributor to the Beneficial Effects of Truncal Vagotomy–Related Bariatric Surgery

Liang¹,

Zhang

Liu

et al. 2022

OBES SURG

View full text Add to dashboard Cite

Purpose Evidences about the gut microbiota role in weight loss after bariatric surgery (BS) are growing. The objective of this study was to observe the changes of gut microbiota after sleeve gastrectomy (SG) and SG plus truncal vagotomy (SG-TV) and identify specific microbes that may contribute to the improvement of obesity after surgeries. Materials and Methods Forty high-fat diet-induced obesity (DIO) mice were randomized to SG, SG-TV, or sham operation (SH) groups. Body weight (BW) and fast blood glucose (FBG) were measured before and 1, 2, 4, 8, and 12 weeks post-operatively. Fecal samples were collected before and at post-operative week 12 and profiled using 16S rRNA relative and absolute quantitative sequencing. Results After the surgery, the SG and SG-TV surgeries significantly reduce BW and FBG levels compared with SH, and the SG-TV achieved better effects than SG. A decreasing trend in alpha diversity of gut microbiota and significant changes in taxonomic composition were observed after surgeries. Then, we identified a set of microbes and pathways significantly different in abundance after BS. The genus Parabacteroides and one pathway (polyketide sugar unit biosynthesis) increased in SG-TV group specially, which was also negatively correlated with BW and FBG. Conclusion SG and SG-TV indeed achieve effects of weight loss, but TV could enhance the efficacy of SG. The identified different microbes and pathways, like Parabacteroides, polyketide sugar unit biosynthesis, may partly mediate the beneficial effects of BS, and thus possibly contribute to the development of novel bacteria-based therapeutic approaches. Graphical Abstract

show abstract