Metabolic disturbances and cardiovascular risk factors in obese children with vitamin D deficiency

Çolak, Rüya; Anil, Manes; Yaşar, Filiz; Bakiler, Ali Rahmi; Pirgon, Özgür; Helvacı, Mehmet Rami; Dündar, Bumin Nuri

doi:10.1016/j.arcped.2019.12.005

Cited by 11 publications

(9 citation statements)

References 31 publications

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“…24,25 Regarding low vitamin D levels, a Turkish study reported a much greater vitamin D deficiency prevalence (<20 ng/ml; 75%) in children with obesity, whereas a Danish study exhibited a lower vitamin D deficiency (<30 ng/mL levels; 16.5%). 26,27 Homostasis model for IR and FI were used to evaluate IR in out patients, and we observed higher values (64.7%, 52.5%) than those decided by Brazilian study (40.5%,39.2). 28 Interestingly, in both studies, hyperglycemia was not prevalent among the studied children even with the high prevalence of IR (mean FBS was 5mmol/L in this study, while it was 5.4 mmol/L in the Brazilian study); however, they concluded a similar detection rate of IR between HOMA-IR and FI, while we had a higher detection rate with HOMA-IR.…”

Section: Associations Of Indices Of Ir With Adiposity Measurescontrasting

confidence: 49%

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Indices of insulin resistance and adiposity can detect obesity-related morbidity in pediatrics

Abdelhamed

Salah

ALqudsi

et al. 2022

SMJ

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Section: Associations Of Indices Of Ir With Adiposity Measurescontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Indices of insulin resistance and adiposity can detect obesity-related morbidity in pediatrics

Abdelhamed

Salah

ALqudsi

et al. 2022

SMJ

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“…In contrast to before mentioned studies, Colak et al [49] reported no relationship between vitamin D deficiency and dyslipidemia or abnormal glucose homeostasis. On the other hand, they showed that serum 25OHD levels were negatively associated with 24-h ambulatory blood pressure and carotid intima-media thickness (p < 0.05).…”

Section: Vitamin D Deficiency and Cardiovascular Risk Factorsmentioning

confidence: 79%

“…Many recent studies have investigated the association between vitamin D deficiency and cardiovascular risk factors in overweight and obese children [49][50][51][52][53]. Some studies found a higher prevalence of dyslipidemia in vitamin D deficiency obese subjects compared to subjects with vitamin D sufficiency [50][51][52].…”

Section: Vitamin D Deficiency and Cardiovascular Risk Factorsmentioning

confidence: 99%

“…We must consider that obesity itself is associated to elevated cardiovascular risk factors and metabolic syndrome [47], and that 25OHD deficiency has a very high prevalence in obese subjects [49][50][51][52]. Indeed, obese individuals are sedentary, little exposed to sunlight and with poor diets, leading to lower vitamin D levels.…”

Section: Vitamin D Deficiency and Cardiovascular Risk Factorsmentioning

confidence: 99%

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Vitamin D and Cardiovascular Risk: Which Implications in Children?

Savastio

Pozzi

Tagliaferri

et al. 2020

IJMS

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Vitamin D (25OHD) pleiotropic effects are widely recognized and studied. Recently, vitamin D cardiovascular effects are gaining interest, especially in children, although the studies present conflicting data. Some randomized controlled trials (RCTs) have demonstrated that cardiovascular risk markers, such as lipid parameters, inflammation markers, blood pressure, and arterial stiffness, are unaffected by vitamin D supplementation. By contrast, other studies show that low vitamin D levels are associated with higher risk of cardiovascular disease (CVD) and mortality, and support that increased risk of these diseases occurs primarily in people with vitamin D deficiency. An update on these points in pediatric patients is certainly of interest to focus on possible benefits of its supplementation.

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Association of serum 25‐hydroxyvitamin D with metabolic disturbances in adolescents

Kaneva

Потолицына

Bojko

2022

American J Hum Biol

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Objectives Data concerning the association of vitamin D with metabolic disturbances in adolescents are contradictory. The aim of this study was to identify metabolic abnormalities in adolescents with 25‐hydroxyvitamin D (25[OH]D) deficiency and to determine informative indices for the early detection of these metabolic disturbances. Methods A cross‐sectional observational study including 90 adolescents aged 13–15 years was carried out during the winter. Anthropometric measures were collected. Fasting blood samples were assessed for the following parameters: serum 25(OH)D, lipids, and glucose. Results The majority of the study adolescents had low 25(OH)D concentration. The prevalence of 25(OH)D deficiency (<12 ng/ml) and insufficiency (12–20 ng/ml) in adolescents was 34.4% and 55.6%, respectively. Among the metabolic disturbance, hypo‐high‐density lipoprotein cholesterolemia prevailed in the adolescents, while hypercholesterolemia, hypertriglyceridemia, and hyperglycemia were rare. 25(OH)D status showed an association with the metabolic score for insulin resistance (METS‐IR, r = −0.40; p < .001), high‐density lipoprotein cholesterol level (r = 0.31; p = .003), atherogenic index of plasma (r = −0.30; p = .004) and body mass index (r = −0.23, p = .032). There were no significant correlations between 25(OH)D level and other lipid or glucose levels. The degree of hypovitaminosis D affects METS‐IR values. Conclusions 25(OH)D deficiency in the studied adolescents had not yet manifested serious metabolic diseases. Of all the analyzed parameters, METS‐IR was most strongly associated with 25(OH)D level and can be considered a useful marker of early metabolic disturbances in adolescents with 25(OH)D deficiency.

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Metabolic disturbances and cardiovascular risk factors in obese children with vitamin D deficiency

Cited by 11 publications

References 31 publications

Indices of insulin resistance and adiposity can detect obesity-related morbidity in pediatrics

Indices of insulin resistance and adiposity can detect obesity-related morbidity in pediatrics

Vitamin D and Cardiovascular Risk: Which Implications in Children?

Association of serum 25‐hydroxyvitamin D with metabolic disturbances in adolescents

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