Metabolic Clearance and Secretion Rates of Human Prolactin in Normal Subjects and in Patients with Chronic Renal Failure*

Sievertsen, Grant D.; Lim, Victoria S.; Nakawatase, Charlotte; Frohman, Lawrence A.

doi:10.1210/jcem-50-5-846

Cited by 192 publications

(108 citation statements)

References 9 publications

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“…In this case, a direct correlation between physical contact and prolactin levels may not be possible since the daily first-morning urine sample measures accumulated prolactin rather than the immediate changes that occur in the blood while caretakers carry the newborns, as shown by Dixson and George (1982) and Roberts et al (2001) and the present study. Furthermore, the metabolic clearance rate and half-life of plasma prolactin in nonhuman primates are poorly understood, but, in humans, its increase lasts around 50 min (Sassin et al, 1972;Sievertsen et al, 1980), supporting the association between the plasma prolactin levels and physical contact during carrying found here.…”

Section: Discussionsupporting

confidence: 81%

“…A 50-min time lapse was observed prior to data collection and between two successive episodes of carrying to prevent a possible cumulative effect of the preceding carrying episode/physical contact on prolactin levels and because little is known about the metabolic clearance rate and half-life of this hormone in the plasma of nonhuman primates. For humans, it has been demonstrated that the prolactin increase lasts around 50 min (Sassin et al, 1972;Sievertsen et al, 1980). Blood sample collection was made either interrupting the carrying bout or waiting for the bout to end and removing the focal animal and the newborns from their cage.…”

Section: Behavioral Measurementioning

confidence: 99%

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Hormonal changes related to paternal and alloparental care in common marmosets (Callithrix jacchus)

Mota

Franci

Sousa

2006

Hormones and Behavior

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The physiological mechanisms of parental and alloparental care in cooperatively breeding nonhuman primate species such as the common marmoset (Callithrix jacchus) are poorly known. In this study, we examined prolactin and cortisol plasma levels of fathers and older offspring of both sexes, with and without previous experience in infant carrying, around parturition and during infant carrying. Blood samples were collected from fathers and older offspring and prolactin and cortisol were measured by RIA and EIA, respectively. Prolactin levels of both caretakers were not influenced by infant's birth, previous experience or proximity to parturition. However, prolactin levels increased in both caretakers while in physical contact with infants and also with the number of infants being carried in older offspring. These findings suggest that increased prolactin seems to be mainly due to physical effort rather than a physiological trigger of paternal and alloparental care in common marmosets. Cortisol levels were higher for experienced fathers shortly before parturition which could act to reinforce affiliative bonds between breeding males and females at this time or in the ability of males to detect the proximity of the parturition or both. D

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Section: Discussionsupporting

confidence: 81%

Section: Behavioral Measurementioning

confidence: 99%

Hormonal changes related to paternal and alloparental care in common marmosets (Callithrix jacchus)

Mota

Franci

Sousa

2006

Hormones and Behavior

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“…There were no significant differences between the mean PRL values at 180 min (74.1±9.7 ng/ml) and 240 min (59.7±10.7 ng/ml). The metabolic half life of plasma PRL is reported to be about 53 min (Sievertsen 1980). If sulpiride induced DA inhibition, and the stimulated PRL release were not maintained, PRL value at 240 min should be below 50% of the value at 180 min.…”

Section: Discussionmentioning

confidence: 99%

Evidence for endogenous dopaminergic control of GH release in man.

Hanew

Sasaki

Yoshinaga

1981

Tohoku J. Exp. Med.

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In order to determine whether or not there is a tonic dopamine (DA) control of GH release, the effect of an anti-dopaminergic agent, sulpiride, on GH secretion was studied in 12 normal subjects. After the administration of sulpiride, serum concentrations of sulpiride reached a peak value (1.93+0.1 µg/ml, mean+s.E.M., n=6) at 15 min and then showed a gradual decrease. Concomitantly, mean plasma prolactin (PRL) showed a rapid elevation, with a peak value of 161.9+11.5 ng/ml at 30 min, followed by a gradual decrease. Even at 180 min after sulpiride injection, the plasma PRL was still 9 times higher than the initial level (p<0.005). Within 90 min after the injection, 12 subjects showed a minimal but significant decrease in GH (from 0.78+0.17 to 0.32+0.03 ng/ml, p<0.02). After another 90 min, the plasma GH level increased and the mean peak value (8.1+2.7 ng/ml) at 180 min was significantly higher than the initial value (p<0.02). From these observations, it was suggested that sulpiride inhibited the endogenous DA activity over 180 min, and that the GH decrease within 90 min was due to a suppression of endogenous DA activity. Factors other than DA, however, might be considered for the GH increase after 90 min. dopamine; GH; prolactin; sulpiride It is well known that dopaminergic agonists, e.g. L-dopa, apomorphine, piribedil and CB-154, have stimulatory effects on GH secretion in man (Eddy et al. 1971;Lal et al. 1972;Camanni et al. 1975;Orsetti et al. 1978). In addition, it has been reported that dopamine (DA)-antagonists, e.g. pimozide and sulpiride, can inhibit the GH release induced by DA-agonists (Liuzzi et al. 1976;Lal et al. 1977; Mori et al. 1977). These findings suggest a role for DA in the release of GH. Effects produced by pharmacological doses of DA-agonists, however, do not necessarily imply that endogenous DA has a physiological role in the control of GH secretion. To test whether this is in fact the case, we examined the effect of a DAantagonist, sulpiride (Restelli et al. 1975;MacLeod and Robyn 1977). If there is a tonic DA control of GH release, sulpiride would be expected to block it with resultant changes in plasma GH.

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“…The mechanism of hyperprolactinaemia however, is not entirely clear. Prolongation of the half-life of prolactin due to reduced renal clearance probably plays a role (Gomez et al, 1980), but lactotroph resistance to inhibition by dopamine has also been shown in chronic renal failure (Sievertsen et al, 1980). The exact nature of the hypothalamo-pituitary-testicular dysfunction found in chronic renal failure is complex.…”

Section: Renal Diseasementioning

confidence: 99%