Metabolic characterization of two different non-alcoholic fatty liver disease pre-clinical mouse models

Gallego‐Durán, Rocío; Álvarez-Amor, Leticia; Gil‐Gómez, Antonio; Rojas, Ángela; Muñoz, Rodrigo; Cádernas-García, Antonio; Maya-Miles, Douglas; Montero‐Vallejo, Rocío; Gato, Sheila; Torrijos, Yolanda Sánchez; Ampuero, Javier; Martín, Francisco; Romero‐Gómez, Manuel

doi:10.17235/reed.2019.6083/2018

Cited by 4 publications

(4 citation statements)

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“…For instance, for pharmacological testing or search for novel treatments or even reversion of phenotype, usually long diets are not needed 124 but when the outcome is a more physiological animal model as in the case of a high-fat high-fructose diet, the dietary regimen may extend up to 52 weeks. 123…”

Section: Length Of Dietmentioning

confidence: 99%

“…120 Wild type (WT) mice fed CDAA diet develop steatosis, inflammation, fibrosis, and a supplementation with a high-fat diet (CDAHFD) is also widely used, to sort out the weight loss. 121,122 Mice develop weight gain, hepatic fibrosis and an increase in alanine aminotransferase (ALT) and aspartate aminotransferase (AST), due to excessive fat accumulation in the liver 121,123 (Please refer to Table 2).…”

Section: Choline-deficient L-amino Acid-defined (Cdaa) Dietmentioning

confidence: 99%

“…In an attempt to mimic the natural history of the disease as it occurs in humans, the diet has to be long enough to mirror the human phenotype. For instance, for pharmacological testing or search for novel treatments or even reversion of phenotype, usually long diets are not needed 124 but when the outcome is a more physiological animal model as in the case of a high‐fat high‐fructose diet, the dietary regimen may extend up to 52 weeks 123 …”

Section: Other Additional Factors To Considermentioning

confidence: 99%

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Novel insights into metabolic‐associated steatotic liver disease preclinical models

Montero‐Vallejo,

Maya‐Miles,

Ampuero

et al. 2024

Liver International

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Metabolic‐associated steatotic liver disease (MASLD) encompasses a wide spectrum of metabolic conditions associated with an excess of fat accumulation in the liver, ranging from simple hepatic steatosis to cirrhosis and hepatocellular carcinoma. Finding appropriate tools to study its development and progression is essential to address essential unmet therapeutic and staging needs. This review discusses advantages and shortcomings of different dietary, chemical and genetic factors that can be used to mimic this disease and its progression in mice from a hepatic and metabolic point of view. Also, this review will highlight some additional factors and considerations that could have a strong impact on the outcomes of our model to end up providing recommendations and a checklist to facilitate the selection of the appropriate MASLD preclinical model based on clinical aims.

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Section: Length Of Dietmentioning

confidence: 99%

Section: Choline-deficient L-amino Acid-defined (Cdaa) Dietmentioning

confidence: 99%

Section: Other Additional Factors To Considermentioning

confidence: 99%

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Novel insights into metabolic‐associated steatotic liver disease preclinical models

Montero‐Vallejo,

Maya‐Miles,

Ampuero

et al. 2024

Liver International

Self Cite

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“…Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease characterized by the accumulation of fat in the liver, which can be associated with obesity, and can progress to brosis, cirrhosis, and even liver cancer [1].NAFLD is considered as an important feature of metabolic syndrome and an important factor causing cardiovascular diseases. More studies have suggested that NAFLD is related to male sexual dysfunction and reproductive dysfunction [2].NAFLD has also been shown to be associated with poor metabolism and oxidative stress [3].Other studies have linked NAFLD to sedentary behavior and poor eating habits [4].NAFLD is one of the most common chronic liver diseases in developed countries [5]. Except for lifestyle intervention, no drugs are currently approved for the treatment of NAFLD, so more clinical studies are needed to nd new methods for the treatment and management of NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Study on the Independent Effect of Thyroid Hormone Based on Uric Acid Level on NAFLD

Chao

Chen

2020

Preprint

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Objective:This study aims to further explain the correlation among NAFLD, hyperuricemia and thyroid function and to find independent risk factors for each other.Methods:Datas were obtained from subjects who underwent health examination in the Health promotion centre of Sir Run Run Shaw hospital of Zhejiang University from January 2017 to February 2019.The diagnosis of NAFLD was according to the clinical diagnosis of the Guidelines.Serum uric acid (SUA) >360 mol/L (female) and SUA>420 mol/L (male) were enrolled in the hyperuricemia group.R software was used for statistical analysis.Results:55,449 subjects were included in the analysis.Gender ratio, age, BMI, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose, HbA1c, triglyceride, high-density lipoprotein, glutamate transaminase, glutamate transaminase, urea nitrogen, creatinine, FT3, FT4 and TSH were significantly different between the two groups.age, BMI, waist circumference, diastolic blood pressure, rapid blood glucose, HbA1c, total cholesterol, low-density lipoprotein, AST, and uric acid were all independent risk factors for NAFLD.In the normal uric acid group, variables other than systolic blood pressure and TSH were independent factors of NAFLD.In the hyperuricemia group, all variables except systolic blood pressure, FT4 and TSH were independent factors of NAFLD.Conclusion:The level of uric acid is related to the occurrence of NAFLD. Hyperuricemia is one of the independent risk factors of NAFLD.TSH level is not related to the occurrence of NAFLD, while FT3 and FT4 may be related to NAFLD.

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Study on the independent effect of thyroid hormone based on uric acid level on NAFLD

Chao

Chen

2021

J Health Popul Nutr

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Objective This study aims to explain the correlation among non-alcoholic fatty liver disease (NAFLD), hyperuricemia, and thyroid function and to find independent risk factors for each other. Methods Data were obtained from subjects who underwent health examination in the Health Promotion Centre of Sir Run Run Shaw Hospital of Zhejiang University from January 2017 to February 2019. The diagnosis of NAFLD was according to the clinical diagnosis of the guidelines. Serum uric acid (SUA) > 360 μmol/L (female) and SUA > 420 μmol/L (male) were enrolled in the hyperuricemia group. R software was used for statistical analysis. Results 55,449 subjects were included in the analysis. 34.27% of patients were classified as NAFLD group (N=19004), and 65.73% of patients were classified as non-NAFLD group (N=36445). The levels of gender ratio, age, BMI, waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), HbA1c, triglyceride (TG), high-density lipoprotein (HDLC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea nitrogen (BUN), creatinine (CR), FT3, FT4, and TSH were significantly different between the non-NAFLD group and NAFLD group. Age, BMI, waist circumference, DBP, fFBG, HbA1c, total cholesterol (TC), low-density lipoprotein (LDLC), AST, and UA were all independent risk factors for NAFLD. In the normal uric acid group, variables other than SBP and TSH were independent factors of NAFLD. In the hyperuricemia group, all variables except SBP, FT4, and TSH were independent factors of NAFLD. Conclusion The level of uric acid is related to the occurrence of NAFLD. Hyperuricemia is one of the independent risk factors of NAFLD. TSH level is not related to the occurrence of NAFLD, while FT3 and FT4 may be related to NAFLD.

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Metabolic characterization of two different non-alcoholic fatty liver disease pre-clinical mouse models

Cited by 4 publications

References 0 publications

Novel insights into metabolic‐associated steatotic liver disease preclinical models

Novel insights into metabolic‐associated steatotic liver disease preclinical models

Study on the Independent Effect of Thyroid Hormone Based on Uric Acid Level on NAFLD

Study on the independent effect of thyroid hormone based on uric acid level on NAFLD

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