Metabolic changes of cancer cachexia — second of two parts

Blaauw, Ivo de; Deutz, N.E.P.; Meyenfeldt, M.F. von

doi:10.1016/s0261-5614(97)80033-7

Cited by 30 publications

(14 citation statements)

References 79 publications

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“…Cancer-related nutritional deterioration has been traditionally attributed to anorexia and metabolic derangement [3,21,22]. Despite the fact that nutritional deterioration is associated with functional impairment [6], the interaction between nutrition and QoL is as-yet unexplored [7].…”

Section: Discussionmentioning

confidence: 99%

Cancer: disease and nutrition are key determinants of patients? quality of life

Ravasco

Grillo

Marques‐Vidal

et al. 2004

Supportive Care in Cancer

263

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Section: Discussionmentioning

confidence: 99%

Cancer: disease and nutrition are key determinants of patients? quality of life

Ravasco

Grillo

Marques‐Vidal

et al. 2004

Supportive Care in Cancer

263

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“…The lactate formed is reconverted into glucose via the Cori cycle. This inefficient process is increased by up to 50% in cancer patients and accounts for up to 60% of the lactate production [55,56]. …”

Section: Bcaas In Cancermentioning

confidence: 99%

The Complex Role of Branched Chain Amino Acids in Diabetes and Cancer

O’Connell¹

2013

Metabolites

117

101

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The obesity and diabetes epidemics are continuing to spread across the globe. There is increasing evidence that diabetes leads to a significantly higher risk for certain types of cancer. Both diabetes and cancer are characterized by severe metabolic perturbations and the branched chain amino acids (BCAAs) appear to play a significant role in both of these diseases. These essential amino acids participate in a wide variety of metabolic pathways, but it is now recognized that they are also critical regulators of a number of cell signaling pathways. An elevation in branched chain amino acids has recently been shown to be significantly correlated with insulin resistance and the future development of diabetes. In cancer, the normal demands for BCAAs are complicated by the conflicting needs of the tumor and the host. The severe muscle wasting syndrome experience by many cancer patients, known as cachexia, has motivated the use of BCAA supplementation. The desired improvement in muscle mass must be balanced by the need to avoid providing materials for tumor proliferation. A better understanding of the complex functions of BCAAs could lead to their use as biomarkers of the progression of certain cancers in diabetic patients.

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“…Aggressive tumor growth may also interfere with normal cardiac metabolism (6). Depleted fat tissue and reduced fatty acid substrate metabolism in combination with impaired glucose tolerance, reduced insulin sensitivity, and aberrant pancreatic insulin release have been reported in cancer (7,8). Epidemiologic evidence suggests a decrease in cancer risk in subjects treated with the insulin-sensitizing agent metformin (9) and higher rates of cancer in patients with metabolic diseases and impaired insulin signaling (10).…”

Section: Introductionmentioning

confidence: 99%