Cancer: disease and nutrition are key determinants of patients? quality of life

Ravasco, Paula; Grillo, I. Monteiro; Marques‐Vidal, Pedro; Camilo, M.

doi:10.1007/s00520-003-0568-z

Cited by 263 publications

(73 citation statements)

References 30 publications

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“…Previous studies have reported that weight loss is associated with a lower QoL. Weight loss has also been shown to be an important prognostic indicator of poor survival [6], and energy intake has been found to be correlated with symptoms including nausea, vomiting, and diarrhea [20]. This longitudinal study over 12 months included some patients with advanced stages of disease which not surprisingly resulted in significant attrition between T2 and T3.…”

Section: Study Strengths and Limitationsmentioning

confidence: 94%

The prevalence of nutrition impact symptoms and their relationship to quality of life and clinical outcomes in medical oncology patients

Tong

Isenring

Yates

2008

Support Care Cancer

145

108

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Section: Study Strengths and Limitationsmentioning

confidence: 94%

The prevalence of nutrition impact symptoms and their relationship to quality of life and clinical outcomes in medical oncology patients

Tong

Isenring

Yates

2008

Support Care Cancer

145

108

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“…Several studies have shown that cachexia itself contributes to lower scores more so than tumor location, duration, or stage [17, 18]. Outward effects of cachexia include a decrease in physical activity and the ability to perform activities of daily living, which may play a role in a person's psychological well-being.…”

Section: Clinical Significance Of Cancer Cachexiamentioning

confidence: 99%

Inflammation Based Regulation of Cancer Cachexia

Onesti

Guttridge

2014

BioMed Research International

135

129

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Cancer cachexia, consisting of significant skeletal muscle wasting independent of nutritional intake, is a major concern for patients with solid tumors that affects surgical, therapeutic, and quality of life outcomes. This review summarizes the clinical implications, background of inflammatory cytokines, and the origin and sources of procachectic factors including TNF-α, IL-6, IL-1, INF-γ, and PIF. Molecular mechanisms and pathways are described to elucidate the link between the immune response caused by the presence of the tumor and the final result of skeletal muscle wasting.

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“…Malnutrition is observed in up to 80% of patients with advanced cancer [1–5]. Decreased dietary intake, cancer cachexia (characterized mainly by weight loss and muscle wasting), and nutrition impact symptoms may all contribute to cancer-related malnutrition [6].…”

Section: Introductionmentioning

confidence: 99%

A longitudinal study investigating quality of life and nutritional outcomes in advanced cancer patients receiving home parenteral nutrition

et al. 2014

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BackgroundIn cancer patients where gastrointestinal function is marginal and malnutrition significant enough to result in the requirement for intensive nutrition support, parenteral nutrition (PN) is indicated. This longitudinal study examined the quality of life (QoL) and nutritional outcomes in advanced cancer patients receiving home PN (HPN).MethodsFifty-two adult cancer patients (21 males, 31 females, average age 53 years) treated at a specialized cancer facility between April 2009 and November 2011 met criteria. QoL and nutritional status were measured at baseline and every month while on HPN using EORTC-QLQ-C30, Karnofsky Performance Status (KPS), and Subjective Global Assessment (SGA). Repeated measures ANOVA and Generalized Estimating Equations (GEE) were used to evaluate longitudinal changes in QoL and SGA.ResultsCancer diagnoses included pancreatic (n = 14), colorectal (n = 11), ovarian (n = 6), appendix (n = 5), stomach (n = 4) and others (n = 12). Average weight loss 6-months prior to HPN was 13.2 kg (16.9%). Average weight at initiation of HPN was 62.2 kg. In patients with available follow-up data after 1 month (n = 39), there was a significant improvement in SGA, weight (61.5 to 63.1 kg; p = 0.03) and KPS (61.6 to 67.3; p = 0.01) from baseline. Similarly, after 2 months (n = 22), there was an improvement in global QoL (37.1 to 49.2; p = 0.02), SGA, weight (57.6 to 60 kg; p = 0.04) and KPS (63.2 to 73.2; p = 0.01) from baseline. Finally, after 3 months (n = 15), there was an improvement in global QoL (30.6 to 54.4; p = 0.02), SGA, weight (61.1 to 65.9 kg; p = 0.04) and KPS (64.0 to 78.7; p = 0.002) from baseline. Upon GEE analysis, every 1 month of HPN was associated with an increase of 6.3 points in global QoL (p<0.001), 1.3 kg in weight (p = 0.009) and 5.8 points in KPS (p<0.001).ConclusionsHPN is associated with an improvement in QoL, KPS and nutritional status in advanced cancer patients, irrespective of their tumor type, who have compromised enteral intake and malnutrition. The greatest benefit was seen in patients with 3 months of HPN, although patients receiving HPN for 1 or 2 months also demonstrated significant improvements.

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Cancer: disease and nutrition are key determinants of patients? quality of life

Abstract: Although cancer stage was the major determinant of patients' QoL globally, there were some diagnoses for which the impact of nutritional deterioration combined with deficiencies in nutritional intake may be more important than the stage of the disease process.

Cited by 263 publications

References 30 publications

The prevalence of nutrition impact symptoms and their relationship to quality of life and clinical outcomes in medical oncology patients

The prevalence of nutrition impact symptoms and their relationship to quality of life and clinical outcomes in medical oncology patients

Inflammation Based Regulation of Cancer Cachexia

A longitudinal study investigating quality of life and nutritional outcomes in advanced cancer patients receiving home parenteral nutrition

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