Metabolic changes in acute cerebral infarction: Findings from proton magnetic resonance spectroscopic imaging

Lin, Ang; Shou, Jixin; Li, Xueyuan; Ma, Lin; Zhu, Xiaohan

doi:10.3892/etm.2013.1418

Cited by 30 publications

(23 citation statements)

References 15 publications

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“… 4 Lin et al studied stroke patients and postulated that decreased NAA/Cr and NAA/Cho ratios, as well as an increased Lac/Cr ratio often indicate irreversible infarction, and the monitoring of the NAA peak may be considered as an indicator for evaluating the effectiveness of treatment for cerebral infarction. 16 In the current case there was both decreased NAA/Cr and NAA/Cho ratios (NAA/creatine (Cr) ratio = 1.01 and NAA/Cho ratio = 0.78 as compared to other side) along with a Lac peak prompting towards an infarction. Thus, we postulate that because the patient had prolonged hyperglycemia that was not controlled, it resulted in “true infarction” leading to irreversible/only partially reversible clinical findings.…”

Section: Discussionmentioning

confidence: 46%

Irreversible Hemichorea–Hemiballism in a Case of Nonketotic Hyperglycemia Presenting as the Initial Manifestation of Diabetes Mellitus

Roy

Das

Mukherjee

et al. 2016

Tremor and Other Hyperkinetic Movements

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Section: Discussionmentioning

confidence: 46%

Irreversible Hemichorea–Hemiballism in a Case of Nonketotic Hyperglycemia Presenting as the Initial Manifestation of Diabetes Mellitus

Roy

Das

Mukherjee

et al. 2016

Tremor and Other Hyperkinetic Movements

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“…Cerebral ischemia leads to a decrease in cerebral blood ow (CBF) and metabolism. Early metabolic changes in the brain of patients with cerebral infarction provide important information concerning diagnosis and treatment [5]. After the onset of ischemic stroke, CBF is disrupted throughout the affected region of the brain; this sharp reduction in blood ow results in de cient adenosine triphosphate levels and subsequent ionic disruption and metabolic failure, which progresses within minutes to neuronal necrosis [6].…”

Section: Transcranial Doppler Combined With Quantitative Electroencepmentioning

confidence: 99%

Transcranial Doppler combined with quantitative electroencephalography brain function monitoring for estimating the prognosis of patients with posterior circulation cerebral infarction

Cao

Song

Wang

et al. 2020

Preprint

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Background: Posterior circulation cerebral infarction (PCCI) leads to decreased cerebral blood flow (CBF) and metabolism. Neural activity is closely related to regional CBF both spatially and temporally. Transcranial Doppler (TCD) combined with quantitative electroencephalography (QEEG) can evaluate neurovascular coupling and involves synergy between the metabolic and vascular systems. This study aimed to monitor brain function using TCD-QEEG and estimate its efficacy in predicting the prognosis of patients with PCCI.Methods: We used TCD-QEEG to perform quantitative brain function monitoring; we recorded the related clinical variables simultaneously. The data were analyzed using a Cox proportional hazards regression model. Receiver-operating characteristic (ROC) curve analysis was used to evaluate the cut-off for the diastolic flow velocity (VD) and (delta+theta)/(alpha+beta) ratio (DTABR). The area under the ROC curve (AUROC) was calculated to assess the predictive validity of the study variables. Results: Forty patients (aged 63.7±9.9 years; 30 men) were assessed. Mortality at 90 days was 40%. The TCD indicators of VD (hazards ratio [HR] 0.168, confidence interval [CI] 0.047–0.597, p=0.006), and QEEG indicators of DTABR (HR 12.527, CI 1.637–95.846, p=0.015) were the independent predictors of the clinical outcomes. The AUROC after the combination of VD and DTABR was 0.896 and showed better predictive accuracy than the Glasgow Coma Scale score (0.75), VD (0.76), and DTABR (0.781; all p<0.05).Conclusion: TCD-QEEG provides a good understanding of the coupling mechanisms in the brain and can improve our ability to predict the prognosis of patients with PCCI.

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“…The most important marker of brain ischaemia in 1H-MRS is the NAA and Lac signal, but some changes can also be detected in the other metabolite signals such as Cho, Cr, Glu, and glutathione. The time changes of these metabolites are one of the contributing factors in diagnosis and prognosis of brain infarction [111,112].…”

Section: Mrs Application In Neural Diseasesmentioning

confidence: 99%

Magnetic Resonance Spectroscopy and its Clinical Applications: A Review

Faghihi

Zeinali-Rafsanjani

Mosleh-Shirazi

et al. 2017

Journal of Medical Imaging and Radiation Sciences

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In vivo NMR spectroscopy is known as magnetic resonance spectroscopy (MRS). MRS has been applied as both a research and a clinical tool in order to detect visible or nonvisible abnormalities. The adaptability of MRS allows a technique that can probe a wide variety of metabolic uses across different tissues. Although MRS is mostly applied for brain tissue, it can be used for detection, localization, staging, tumour aggressiveness evaluation, and tumour response assessment of breast, prostate, hepatic, and other cancers. In this article, the medical applications of MRS in the brain, including tumours, neural and psychiatric disorder studies, breast, prostate, hepatic, gastrointestinal, and genitourinary investigations have been reviewed. R ESUM E La spectroscopie RMN in vivo est appel ee spectroscopie par r esonance magn etique (SRM) en clinique. La SRM a et e utilis ee autant comme outil de recherche que comme outil clinique pour la d etection des anomalies visibles ou non. L'adaptabilit e de la SRM en fait une technique qui peut examiner une grande vari et e d'utilisations m etaboliques dans diff erents tissus. Bien que la SRM soit principalement utilis ee pour les tissus c er ebraux, elle peutêtre utilis ee pour la d etection, la localisation, la d etermination du stade, l' evaluation du caract ere agressif d'une tumeur et l' evaluation de la r eponse tumorale dans le cancer du sein, de la prostate, du foie et d'autres organes. Cette etude, apr es un bref examen des fondements de la SRM, passe en revue les applications m edicales de la SRM dans le cerveau, incluant les tumeurs, les applications m edicales de la SRM, incluant les cancers et l' etude des troubles neurologiques et psychiatriques, ainsi que les examens du sein, de la prostate, du foie et des syst emes gastro-intestinal et g enito-urinaire.

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Metabolic changes in acute cerebral infarction: Findings from proton magnetic resonance spectroscopic imaging

Cited by 30 publications

References 15 publications

Irreversible Hemichorea–Hemiballism in a Case of Nonketotic Hyperglycemia Presenting as the Initial Manifestation of Diabetes Mellitus

Irreversible Hemichorea–Hemiballism in a Case of Nonketotic Hyperglycemia Presenting as the Initial Manifestation of Diabetes Mellitus

Transcranial Doppler combined with quantitative electroencephalography brain function monitoring for estimating the prognosis of patients with posterior circulation cerebral infarction

Magnetic Resonance Spectroscopy and its Clinical Applications: A Review

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