Metabolic changes associated with sustained 48-Hr shivering thermogenesis in the newborn pig

Berthon, D; Herpin, Patrick; Bertin, R; Marco, F. De; Dividich, Jean Le

doi:10.1016/0305-0491(96)00044-2

Cited by 25 publications

(19 citation statements)

References 37 publications

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“…Interestingly, this should result in an increased total surface of lipid droplets and favour lipid utilisation. This conclusion is consistent with the postnatal and cold-induced decrease in RQ and with the finding that cold-exposed piglets exhibit enhanced muscular potential for capturing and oxidising lipids [5]. In addition, at 5 days of life lipid droplets are wedged between myofibrils and intermyofibrillar mitochondria, an ideal position for optimising substrate supply to oxidative metabolism and sustained shivering [12,24].…”

Section: Structures Involved In Skeletal Muscle Metabolismsupporting

confidence: 82%

Effect of age and cold exposure on morphofunctional characteristics of skeletal muscle in neonatal pigs

Herpin

Lossec

Schmidt

et al. 2002

Pfl�gers Archiv European Journal of Physiology

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Muscular changes accompanying and/or promoting the rapid postnatal improvement of the thermogenic efficiency of shivering were investigated in piglets. Animals were obtained at birth or killed after 5 days at thermoneutrality (34-30 degrees C) or in the cold (24-15 degrees C), to stimulate intense shivering thermogenesis. Fast-twitch-glycolytic (longissimus lumborum) and slow-twitch-oxidative (rhomboid) muscles were prepared for electron microscopic examination and chemical measurements. Muscle-specific changes in energy stores and metabolism were observed after birth, including the switch from glycogen to lipids and variation of the lactate/pyruvate ratio corresponding to the progressive acquisition of the metabolic type of the mature muscles. There was major age-related and/or cold-induced development of the structures involved in excitation-contraction coupling (triadic profiles, +80% in the cold), oxidative metabolism (number of lipid droplets, +81% with age in the cold; number of mitochondria, +29% with age or cold; surface of mitochondrial inner membranes, +18% with age and +32% in the cold) and contraction potential (myofibril volume, +62% with age). In contrast, neither age nor cold affected capillary volume density and capillary-to-fibre ratio. The observed changes reflect the immaturity and remarkable plasticity of piglet skeletal muscle and are likely to underlie its enhanced capacity for shivering thermogenesis after birth.

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Section: Structures Involved In Skeletal Muscle Metabolismsupporting

confidence: 82%

Effect of age and cold exposure on morphofunctional characteristics of skeletal muscle in neonatal pigs

Herpin

Lossec

Schmidt

et al. 2002

Pfl�gers Archiv European Journal of Physiology

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“…Specifically, cold acclimation in ducks led to increased capillary density and a shift to slow-oxidative muscle fiber types (Duchamp et al, 1992). Increased cytochrome oxidase activity was observed in ducks (Barre et al, 1987), king penguins (Duchamp et al, 1991) and pigs (Berthon et al, 1996). We previously reported an increase in muscle mitochondrial volume in short-tailed opossums, Monodelphis domestica .…”

mentioning

confidence: 79%

Cost of transport is increased after cold exposure inMonodelphis domestica: training for inefficiency

Schaeffer

Villarin

Pierotti

et al. 2005

Journal of Experimental Biology

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control or exercise-trained animals, indicating greater oxidative capacity. Finally, we identified an uncoupling protein 3 homologue, whose gene expression was upregulated in skeletal muscle of cold-exposed Monodelphis domestica. Cold exposure provided a potent stimulus for muscle plasticity, driving a fast-to-slow transition more effectively than exercise training. However, linked to the dramatic shift in muscle properties is an equally dramatic increase in whole animal muscle energetics during locomotion, suggesting an uncoupled state, or 'training for inefficiency'.

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“…Thus, in animals that possess BAT, the role of skeletal muscle in chronic adaptive thermogenesis appears to be relatively small. However, the role of skeletal muscle in adaptation to cold exposure in the absence of BAT is the subject of ongoing inquiry using numerous model species, including ducks (Barre et al 1985;Duchamp and Barre 1993), chickens (Raimault et al 2001), pigs (Berthon et al 1996), goats (Schaeffer et al 2001), and humans (Hong et al 1987). The common theme of muscle adaptation to cold in the absence of BAT is an altered metabolic phenotype in response to chronic cold stress, a role obscured by the involvement of BAT in small placental mammals.…”

Section: Introductionmentioning

confidence: 99%

Chronic Cold Exposure Increases Skeletal Muscle Oxidative Structure and Function inMonodelphis domestica, a Marsupial Lacking Brown Adipose Tissue

Schaeffer

Villarin

Lindstedt

2003

Physiological and Biochemical Zoology

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Monodelphis domestica (Marsupialia: Didelphidae) was used as a model animal to investigate and compare muscle adaptation to exercise training and cold exposure. The experimental treatment consisted of four groups of animals: either warm or cold acclimation temperature and with or without endurance exercise training. Maximal aerobic capacity during a running VO2max test in the warm-exercised or cold-exposed (with or without exercise) groups was about 130 mL O(2)/kg/min, significantly higher than the warm-acclimated controls at 113.5 mL O(2)/kg/min. Similarly, during an acute cold challenge (VO2summit), maximal aerobic capacity was higher in these three experimental groups at approximately 95 mL O(2)/kg/min compared with 80.4 mL O(2)/kg/min in warm-acclimated controls. Respiratory exchange ratio was significantly lower (0.89-0.68), whereas relative heart mass (0.52%-0.73%) and whole-body muscle mitochondrial volume density (2.59 to 3.04 cm(3)) were significantly higher following cold exposure. Chronic cold exposure was a stronger stimulus than endurance exercise training for tissue-specific adaptations. Although chronic cold exposure and endurance exercise are distinct challenges, physiological adaptations to each overlap such that the capacities for aerobic performance in response to both cold exposure and running are increased by either or both treatments.

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Metabolic changes associated with sustained 48-Hr shivering thermogenesis in the newborn pig

Cited by 25 publications

References 37 publications

Effect of age and cold exposure on morphofunctional characteristics of skeletal muscle in neonatal pigs

Effect of age and cold exposure on morphofunctional characteristics of skeletal muscle in neonatal pigs

Cost of transport is increased after cold exposure inMonodelphis domestica: training for inefficiency

Chronic Cold Exposure Increases Skeletal Muscle Oxidative Structure and Function inMonodelphis domestica, a Marsupial Lacking Brown Adipose Tissue

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