Metabolic Bone Disorders in Children with Inflammatory Bowel Diseases

Abstract

In recent years, there has been a noticeable increase in the incidence of inflammatory bowel diseases in the pediatric population. Entry observations demonstrate anemia, malabsorption, deficiencies in vitamin D and calcium. These aspects, together with the systemic action of pro-inflammatory cytokines and steroid therapy are widely recognized as factors influencing bone metabolism. Presently, however, there are very few studies that can be found in the scientific literature on metabolic disorders in patients with IBD, especially in the pediatric population as the coexistence has not been sufficiently examined and understood. This review aims to summarize the currently available literature, as well as assess which areas have information gaps and need further research.

Vitamin D in children with inflammatory bowel disease

“…1). (37) Patofyziologie tohoto procesu je komplexní, je inhibován růst i remodelace kostí. (38) Prevalence výskytu snížené kostní denzity u pacientů s IBD se liší podle užité metodologie od 5 % do 21 %.…”

“…Obr. 1: patofyziologické mechanismy metabolické kostní nemoci u pacientů s nespecifickým střevním zánětem, upraveno podle (37)…”

Pediatric Crohn's disease diagnosis aid via genomic analysis and machine learning

“…Increasing incidence rates of pediatric Crohn's disease (CD) over the past decades have been reported in relevant studies (1,2). Pediatric CD present heterogeneous threat to the health of children, with growth retardation, metabolic bone disorders, bone density reduction and pubertal delay (3)(4)(5). Beyond clinical manifestation, endoscopic and histological examination are considered the most reliable technique for diagnosing CD.…”