Metabolic aspects of adult patients with nonalcoholic fatty liver disease

Abenavoli, Ludovico; Milić, Nataša; Renzo, Laura Di; Preveden, Tomislav; Medić-Stojanoska, Milica; Lorenzo, Antonino De

doi:10.3748/wjg.v22.i31.7006

Cited by 151 publications

(128 citation statements)

References 93 publications

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“…[13] NAFLD has frequently been associated with many metabolic abnormalities, such as insulin resistance, obesity, type 2 diabetes mellitus, and hyperlipidemia, which are the main features of MetS. [14] It has been reported that approximately 90% of the NAFLD patients present more than 1 component of MetS, and about 33% of the patients meet the criteria of MetS. [15] Recent studies have demonstrated a close relationship between serum UA and NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Combined effect of obesity and uric acid on nonalcoholic fatty liver disease and hypertriglyceridemia

Zhang

et al. 2017

Medicine

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Hyperuricemia is associated with metabolic syndrome (MetS), but the association is often confounded by the shared background of obesity. We sought to explore the modifying effects of obesity on the association between uric acid (UA), MetS components, and nonalcoholic fatty liver disease (NAFLD).We conducted a cross-sectional study in a Chinese population of 10,069 participants aged ≥20 years. Multiplicative interaction between obesity (BMI ≥25 kg/m2) and elevated UA was assessed using an interaction term in a logistic regression analysis. The presence of additive interaction was assessed based on the relative excess risk due to the interaction (RERI) and the attributable proportion due to the interaction (AP).There was no evidence of a multiplicative interaction between obesity and elevated UA on MetS components and NAFLD. However, there was a strong additive interaction between obesity and elevated UA with regard to NAFLD (RERI of 6.47 [95% CI 3.42–9.53] for men and 5.87 [1.55–10.19] for women) and hypertriglyceridemia (RERI of 1.38 [0.57–2.20] for men and 1.38 [0.08–2.67] for women). In addition, 42% and 36% of the increased odds of NAFLD for men and women, respectively, can be explained by an interaction between obesity and elevated UA (AP of 0.42 [95% CI (0.30–0.54)] for men and 0.36 [0.17–0.55] for women). Similarly, the interaction accounted for 27% and 26% of the increased risk of hypertriglyceridemia for men and women (AP of 0.27 [0.14–0.41] for men and 0.26 [0.06–0.47] for women).In this population, obesity and elevated UA synergistically interacted to increase the risk of NAFLD and hypertriglyceridemia.

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Section: Introductionmentioning

confidence: 99%

Combined effect of obesity and uric acid on nonalcoholic fatty liver disease and hypertriglyceridemia

Zhang

et al. 2017

Medicine

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“…Recent studies considered NAFLD as a hepatic border of metabolic syndrome (Abenavoli et al 2016). It can progress to liver cirrhosis and end-stage liver disease, and is one of the important causes of hidden-source cirrhosis (Chalasani et al 2012).…”

Section: Dintroductionmentioning

confidence: 99%

Possible association between Helicobacter pylori infection and nonalcoholic fatty liver disease

Chen

Mao

Foster

et al. 2017

Appl. Physiol. Nutr. Metab.

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Possible association between Helicobacter pylori infection (HPI) and nonalcoholic fatty liver disease (NAFLD) has been proposed by several studies with inconsistent conclusions. Here, we studied the association between HPI and NAFLD at three levels: 1.) Genetic level; 2.) Small molecular level; and 3.) Clinical level. Relation data between diseases, genes, and small molecules were acquired from Pathway Studio ResNet showed that HPI rate in NAFLD group was significantly higher than that in the non-NAFLD group (51.9% vs. 43.6%; p-value= 4.9E-4). Multivariate logistic regression results supported the observations and suggested that HPI served as a risk factor for NAFLD in the experiment data studied (odds ratio: 1.387, p-value = 0.018). Results from this study support the hypothesis that complex biological association may exist between HPI and NAFLD, which partially explain the significant clinical co-incidence in the elderly population of south China.

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“…Nonalcoholic fatty liver disease (NAFLD) is a liver entity characterized by elevated serum aminotransferase levels and accumulation of fat in liver accompanied occasionally by inflammation and necrosis resembling alcoholic hepatitis in the absence of heavy alcohol consumption [1][2]. This is the most common chronic liver disease in Western populations and it has been related with metabolic syndrome, adipokines, and insulin resistance [3].…”

Section: Introductionmentioning

confidence: 99%

Cholesteryl Ester Transfer Protein Variant (RS1800777) with Liver Histology in Non-Alcoholic Fatty Liver Disease Patients

et al. 2018

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Introduction and Aims: Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases ranging from simple steatosis without inflammation or fibrosis to nonalcoholic steatohepatitis and in the Western countries has become one of the most prevalent chronic liver diseases related to metabolic and lipid alterations. Cholesteryl ester transfer protein (CETP) participates in high density lipoprotein (HDL)-cholesterol metabolism. The aim of our study was to investigate the influence of polymorphism (rs1800777) of CETP gene on liver histological changes, biochemical parameters, and serum adipokines levels in patients with NAFLD. Material and Methods: A population of 90 patients with NAFLD was recruited in a cross-sectional study. A biochemical analysis (glucose, c-reactive protein, insulin, homeostasis model assessment-insulin resistance, total cholesterol, low density lipoprotein (LDL)-cholesterol, HDL-cholesterol, triglycerides blood, and adipokines (leptin, adiponectin, and resistin) was realized. Genotype of polymorphism (rs1800777) of CETP gene was studied. Results: Eighty-three patients (92.2%) had the genotype GG (wild type group) and 7 patients (7.8%) had the genotype GA (n = 7) or AA (n = 0; mutant type group). Patients with A allele show significant decrease in liver biochemistry parameters – Alanine amino transferase (delta 10.1 ± 9.9 UI/L; p = 0.01), aspartate aminotransferase activity (delta 13.3 ± 9.5 UI/L; p = 0.02), and gammaglutamine transferase levels (delta 39 ± 30.1 UI/L; p = 0.01). Logistic regression analysis indicated that subjects with A-allele carriers were associated with a decreased risk of lobulillar inflammation (OR 0.18, 95% CI 0.04–0.95, p = 0.04) and a decreased risk of steatosis (OR 0.13, 95% CI 0.02–0.89, p = 0.04). Conclusions: A variant of the polymorphism rs1800777 of CETP gene is independently associated with the presence of steatosis and lobulillar inflammation in subjects with proven biopsy NAFLD.

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Metabolic aspects of adult patients with nonalcoholic fatty liver disease

Cited by 151 publications

References 93 publications

Combined effect of obesity and uric acid on nonalcoholic fatty liver disease and hypertriglyceridemia

Combined effect of obesity and uric acid on nonalcoholic fatty liver disease and hypertriglyceridemia

Possible association between Helicobacter pylori infection and nonalcoholic fatty liver disease

Cholesteryl Ester Transfer Protein Variant (RS1800777) with Liver Histology in Non-Alcoholic Fatty Liver Disease Patients

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