Metabolic and endocrine effects of the desogestrel-containing oral contraceptive Mircette™

Berga, Sarah L.

doi:10.1016/s0002-9378(98)70291-1

Cited by 9 publications

(4 citation statements)

References 13 publications

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“…This third generation progestin has been used in newer birth control pills because it is less androgenic and thus should have less effect on carbohydrate metabolism and lipid levels. It is not certain, however, whether this actually occurs with use of OC containing only 20 micrograms ethinyl estradiol (EE) and 0.15 mg desogestrel because only three longitudinal studies have included more than 30 women using this formulation 16-18 and none included a control group not using hormonal contraception. Furthermore, these studies are limited in their generalizability to non-white populations as they included very few of these women or did not conduct analyses by race/ethnicity.…”

mentioning

confidence: 99%

Effect of Injectable and Oral Contraceptives on Serum Lipids

Berenson¹,

Rahman²,

Wilkinson

2009

Obstetrics &Amp; Gynecology

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Objective-To estimate the effects of using depot medroxyprogesterone acetate (DMPA) or oral contraceptives (OC) containing 20 micrograms ethinyl estradiol and 0.15 mg desogestrel on serum lipid levels.Methods-Serum lipids were measured at baseline and every 6 months thereafter for 3 years on 703 white, black, and Hispanic women using DMPA, OC, or nonhormonal (NH) birth control. DMPA discontinuers were followed for up to 2 additional years.Participants completed questionnaires containing demographic and behavioral measures every 6 months and underwent 24 hour dietary recalls annually. Mixed model regression analyses and general estimating equations procedures were used to estimate changes over time in lipids by method, along with their predictors.Results-OC users experienced significantly greater increases in levels of triglycerides (TG), total cholesterol (TC), very low density lipoprotein cholesterol (VLDL-C), and high density lipoprotein cholesterol (HDL-C) than NH users (P<.001). However, no difference was noted in the LDL-C to HDL-C ratio between OC and NH users. Among DMPA users, HDL-C levels initially decreased for 6 months, but then returned to baseline. The LDL-C to HDL-C ratio rose during the first 6 months of DMPA use, but then dropped back to baseline over the next 24 months. After DMPA was discontinued, women who used OC increased their TG, TC, VLDL-C, and HDL-C levels significantly more than those who chose NH (P< .05).Conclusion-Use of very low dose OC containing desogestrel can elevate lipid levels. DMPA users were at increased risk of developing an abnormally low HDL-C level as well as an abnormally high LDL level and an increase in the LDL to HDL cholesterol ratio, although these effects appeared to be temporary.Although a number of investigations have been conducted on the relationship between depot medroxyprogesterone acetate (DMPA) and lipid levels, results are not consistent between studies. For example, some have demonstrated that DMPA does not effect serum lipids while others have shown an adverse relationship. [1][2][3][4] Two others reported a beneficial effect. 5,6 Findings from all these studies are limited because they are cross-sectional in design 3,[6][7][8] or have very small sample sizes. 1,4,5,[9][10][11][12] Only three large trials have been published which NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript followed women for an extended period and they do not agree in their findings. [13][14][15] Furthermore, none of these three studies took into account the effect of diet on lipid levels.Moreover, data are limited on the effects of oral contraceptives (OC) containing only 20 micrograms ethinyl estradiol (EE) and 0.15 mg desogestrel on the lipid profile. This third generation progestin has been used in newer birth control pills because it is less androgenic and thus should have less effect on carbohydrate metabolism and lipid levels. It is not certain, however, whether this actually occurs with use of OC containing only 20 micrograms ethinyl estr...

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mentioning

confidence: 99%

Effect of Injectable and Oral Contraceptives on Serum Lipids

Berenson¹,

Rahman²,

Wilkinson

2009

Obstetrics &Amp; Gynecology

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“…In fact, low-dose oral contraceptives, in comparison with the decrease in estradiol plasma concentrations [6], cause a decrease in lacrimal fluid peroxidase activities and the absence of a cyclic enzyme pattern. These observations permit to highlight two points:…”

Section: Discussionmentioning

confidence: 99%

“…This work aimed to investigate whether oral contraceptives modifying sex hormonal patterns in normocyclic women [6,7] could change lacrimal fluid peroxidase activity levels. Effect of low-dose oral contraceptives on lacrimal fluid peroxidase (U/ml), total protein content (mg/ml) and specific activity (U/ mg) throughout different phases of the menstrual cycle.…”

Section: Introductionmentioning

confidence: 99%

Effect of Oral Contraceptives on Lacrimal Fluid Peroxidase Activity in Women

et al. 2002

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Lacrimal fluid peroxidase has been supposed to be involved in the protection against oxidative damage to the ocular surface. Our recent findings showed the existence of significant cyclic variations in lacrimal fluid peroxidase activity that were positively correlated with those of 17β-estradiol plasma levels throughout the menstrual cycle of fertile women. In the present study lacrimal fluid peroxidase activity of 8 healthy normocyclic women using low-dose oral contraceptives during the monthly cycle was determined. Data showed that low-dose oral contraceptives caused a decrease in lacrimal fluid peroxidase activity and a lack of its cyclic pattern with respect to the enzyme activity of 8 untreated age-matched women. Moreover, this result suggests that lacrimal fluid peroxidase activity could be regulated by estrogen.

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“…Clinical trials reported high efficacy and safety and adverse event profiles similar to those of standard COC formulations. 38 In the initial clinical studies, some cycle irregularities were reported, including absence of withdrawal bleeding and intermenstrual bleeding, which occurred in 5.5 and 12% of total cycles, respectively. 39 Some regimens deliver hormone continuously, without a hormone-free interval.…”

Section: Extended-cycle and Novel Dosing Regimensmentioning

confidence: 99%

The Current Status of Oral Contraceptives: Progress and Recent Innovations

Golobof

Kiley

2016

Semin Reprod Med

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Millions of women in the United States and abroad use oral contraceptive pills. These popular contraceptives are the most common reversible birth control method in the United States, and a wide variety of pills are available for prescription. Oral contraceptives provide safe and effective protection against pregnancy and offer several noncontraceptive benefits. Over the years, advances in the laboratory and knowledge gained through epidemiologic data promoted the development of new contraceptive preparations. Generations of oral contraceptives emerged over time, containing lower doses of estrogens and new and novel progestins. The current review discusses the clinical characteristics of oral contraceptives, with emphasis on basic pharmacology and the evolution of various contraceptive formulations and regimens.

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Metabolic and endocrine effects of the desogestrel-containing oral contraceptive Mircette™

Cited by 9 publications

References 13 publications

Effect of Injectable and Oral Contraceptives on Serum Lipids

Effect of Injectable and Oral Contraceptives on Serum Lipids

Effect of Oral Contraceptives on Lacrimal Fluid Peroxidase Activity in Women

The Current Status of Oral Contraceptives: Progress and Recent Innovations

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