Metaanálisis sobre la efectividad de la budesonida en la enfermedad inflamatoria intestinal

Nos, Pilar; Hinojosa, Joaquín; Gomollón, Fernando; Ponce, Julio

doi:10.1016/s0025-7753(01)71716-2

Cited by 15 publications

(2 citation statements)

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“…However, these traditional corticosteroids are being gradually substituted by new compounds with less side-effects 4 . A recent metanalysis on the use of budesonide enemas for ulcerative colitis showed similar benefits when compared to conventional glucocorticosteroids 5 . Probiotics have been used for various clinical and surgical conditions.…”

Section: Introductionmentioning

confidence: 96%

Effects of budesonide and probiotics enemas on the systemic inflammatory response of rats with experimental colitis

2007

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Section: Introductionmentioning

confidence: 96%

Effects of budesonide and probiotics enemas on the systemic inflammatory response of rats with experimental colitis

2007

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Section: Introductionmentioning

confidence: 96%

Effects of budesonide and probiotics enemas on the colonic mucosa of rats with experimental colitis

et al. 2007

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PURPOSE: To investigate the effect of enemas containing probiotics and budesonide on the colonic mucosa in experimental colitis. METHODS: Fifty male Wistar rats with experimental colitis induced by 10% acetic acid enema were randomized to five groups (10 rats each) according to the treatment: group 1 - saline solution, group 2 - budesonide (0.75 mg/kg/day), group 3 - probiotics (1mg/day), group 4 - probiotics plus budesonide, and group 5 - control, with not-treated rats. The following variables were studied: body weight, macroscopic and microscopic score of the colonic mucosa, and DNA content of the mucosa. RESULTS: All animals lost weight between the beginning and the end of the experiment (280+ 16 mg versus 249+21 mg, p< 0.001). There was no significant difference among the groups in relation to both the macroscopic and histological score. The budesonide + probiotic group showed higher DNA content than control group (1.24+ 0.15 versus 0.92+ 0.30 mg/100mg of tissue, p=0.01). CONCLUSION: Budesonide in addition to probiotics enhance the mucosal trophism in experimental colitis.

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Budesonide for induction of remission in Crohn's disease

Rezaie

Kuenzig

Benchimol

et al. 2015

Cochrane Database of Systematic Reviews

121

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Metaanálisis sobre la efectividad de la budesonida en la enfermedad inflamatoria intestinal

Cited by 15 publications

References 30 publications

Effects of budesonide and probiotics enemas on the systemic inflammatory response of rats with experimental colitis

Effects of budesonide and probiotics enemas on the systemic inflammatory response of rats with experimental colitis

Effects of budesonide and probiotics enemas on the colonic mucosa of rats with experimental colitis

Budesonide for induction of remission in Crohn's disease

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