Meta‐analysis of Vitamin D Deficiency and Risk of Atrial Fibrillation

Zhang, Zhiwei; Yang, Yajuan; Ng, C. M.; Wang, Dandan; Wang, Jianlong; Li, Guangping; Liu, Tong

doi:10.1002/clc.22563

Cited by 41 publications

(41 citation statements)

References 39 publications

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“…Association between vitamin D deficiency and cardiovascular disease (CVD) has been established through observational studies . Vitamin D levels are usually measured by serum 25‐hydroxyvitamin D (25[OH]D).…”

Section: Introductionmentioning

confidence: 99%

“…Association between vitamin D deficiency and cardiovascular disease (CVD) has been established through observational studies. 1,2 Vitamin D levels are usually measured by serum 25-hydroxyvitamin D (25[OH] D). Low levels of serum 25(OH)D are associated with increased prevalence of coronary heart disease 3,4 as well as incident cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D deficiency and electrocardiographic subclinical myocardial injury: Results from National Health and Nutrition Examination Survey‐III

Ahmad

Chevli

et al. 2018

Clinical Cardiology

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Background Association of cardiovascular disease (CVD) with nontraditional risk factors such as vitamin D deficiency has been examined previously. An investigation of the association of vitamin D with subclinical myocardial injury (SC‐MI) based on an electrocardiographic score is a simple, cost‐effective and innovative way to explore this relationship. Hypothesis We hypothesize that low vitamin D levels will be associated with prevalent SC‐MI independent of traditional CVD risk factors, lifestyle factors, and socioeconomic status. Methods This analysis included 6079 participants (58.3 ± 13.1 years; 54.1% women) without CVD from the third National Health and Nutrition Examination Survey. A multivariable logistic regression model was used to examine the association between vitamin D categories (<20, 20‐29, and >30 ng/mL (reference) and cardiac injury score. Results There was an incremental increase in the prevalence of SC‐MI across vitamin D categories with the highest prevalence in <20 ng/mL, followed by 20 to 29 ng/mL and then >30 ng/mL (trend P‐value <0.0001). There was a statistically significant association between vitamin D deficiency (<20 ng/mL) and SC‐MI (odds ratio [OR] (95% confidence interval [CI]): 1.27 (1.04‐1.55), P = 0.04). This association was stronger in men than women (OR (95% CI): 1.74 (1.32‐2.30) vs 0.94 (0.70‐1.25) respectively; interaction P‐value 0.002). Conclusions Vitamin D deficiency is associated with SC‐MI, especially in men. These findings may further highlight the role of nontraditional risk factors in the development of CVD. The value of vitamin D supplementation in the prevention of myocardial ischemia and injury may warrant investigation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency and electrocardiographic subclinical myocardial injury: Results from National Health and Nutrition Examination Survey‐III

Ahmad

Chevli

et al. 2018

Clinical Cardiology

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“…VitD deficiency is known to play a key role in the pathogenesis of CAD, left ventricular hypertrophy and AF [11,15,16] . The vitD deficiency has been shown to be associated with left atrial fibrosis and increased risk of AF recurrence after ablation [17] .…”

Section: Discussionmentioning

confidence: 99%

Is there any Link Between Vitamin D and Recurrence of Atrial Fibrillation after Cardioversion?

Yaman¹,

Cerit²,

Gunsel³

et al. 2020

Braz J Cardiovasc Surg

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Introduction: Atrial fibrillation (AF) is the most common chronic arrhythmia in the elderly population. In symptomatic patients, restoration and maintenance of sinus rhythm improve quality of life. Unfortunately, AF recurrence still occurs in a considerable number of patients after cardioversion (CV). In this study, we aimed to evaluate the association between vitamin D (VitD) and AF recurrence after electrical or medical CV. Method: A total of 51 patients who underwent CV for symptomatic AF were included in the study. AF recurrence was defined as an AF pattern in 12-lead electrocardiography (ECG) recording after CV within 6 months or ECG Holter recording of AF lasting more than 30 seconds at 6-month follow-up. Results: Mean vitD level was 21.4 ng/ml in our study population. VitD level was lower in the AF recurrence group than in the non-recurrence group (18 ng/ml vs. 26.3 ng/ml, respectively; P=0.001). Additionally, left atrial diameter was larger in the AF recurrence group compared to the non-recurrence group (4.4 vs. 4.1, P=0.025). Patients with AF recurrence were older than patients without AF recurrence, and, although the prevalence of hypertension is higher in the AF recurrence group, there was no statistically significant difference (P=0.107, P=0.867). Conclusion: In our study, there is a strong association between vitD level and AF recurrence after CV. VitD deficiency might be a predictor of high risk of AF recurrence after CV and vitD supplementation during the follow-up might help the maintenance of sinus rhythm.

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“…39 Recently, the results of studies have shown that increased reactive oxygen species (ROS) due to elevated oxidative stress levels increase the cardiac inflammatory indices such as C-reactive protein (CRP) and the increase in age-related apoptosis. 40 Consequently, it is possible that atrial negative regulation leads to a pre-excitation syndrome or a block in the AV node in post-menopause period. 6 Also, studies have exhibited that impulse delay in the AV node and atrial depolarization is increased with the aging process.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Electrocardiogram Indices in Postmenopausal Women: Effects of Aerobic Exercise and Detraining

Tartibian

Afsargharehbagh

Malandish

et al. 2018

Int J Basic Sci Med

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Introduction: electrocardiogram (ECG) indices as a valuable tool for the diagnosis depolarization and repolarization of the myocardium are affected by aerobic exercise and detraining. The purpose of this study was to investigate the effects of 12-week moderate-intensity aerobic exercise and 5 months detraining on electrocardiogram (ECG) indices in post-menopausal women. Methods: Twenty-four post-menopausal women aged 50-70 years were randomly assigned to Exercise (E, n=12) and Control (C, n=12) groups. E group performed of 12 weeks moderate-intensity aerobic exercise program (W-WJMIAEP-R), and then 5 months detraining remained, but the C group participated in no intervention during 8-month. The ECG indices were measured at baseline, after 12-week exercise, and after 5-month detraining. Results: After 12-week in between-groups, ECG indices were not significantly different (P>0.05), except P-R interval (P≤0.05). After 5-month detraining in between-groups were not a significant difference for dependent variables (P>0.05), except P-R segment and S-T interval (P≤0.05). Conclusion: The Results suggest that 12 weeks of W-WJMIAEP-R increases P-R interval in sedentary post-menopausal women that is likely to be effective in preventing heart arrhythmias. The P-R segment and S-T interval decreased significantly after 5 months detraining period that 12 weeks W-WJMIAEP-R induced-ECG positive adaptations such as decrease P-R segment and S-T interval are maintained even after 5-month detraining and consequently prevents the increase in atrial aging process in postmenopausal women.

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Meta‐analysis of Vitamin D Deficiency and Risk of Atrial Fibrillation

Cited by 41 publications

References 39 publications

Vitamin D deficiency and electrocardiographic subclinical myocardial injury: Results from National Health and Nutrition Examination Survey‐III

Vitamin D deficiency and electrocardiographic subclinical myocardial injury: Results from National Health and Nutrition Examination Survey‐III

Is there any Link Between Vitamin D and Recurrence of Atrial Fibrillation after Cardioversion?

Assessment of Electrocardiogram Indices in Postmenopausal Women: Effects of Aerobic Exercise and Detraining

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