Meta-analysis of the relationship of mycotoxins with biochemical and hematological parameters in broilers

Andretta, Inés; Kipper, Marcos; Lehnen, Cheila Roberta; Lovatto, Paulo Alberto

doi:10.3382/ps.2011-01813

Cited by 44 publications

(34 citation statements)

References 17 publications

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“…In this study, a high level of NH 3 decreased the serum globulin concentration on the third week, which is partly in agreement with the results of previous research (Javed et al, 1995;Stanley et al, 2004;Gao et al, 2009;Andretta et al, 2012;Li et al, 2012). Moreover, in this study, NH 3 and RH had an additive detrimental effect on albumin, total protein, and globulin.…”

Section: Discussionsupporting

confidence: 93%

Ammonia concentration and relative humidity in poultry houses affect the immune response of broilers

Wei

et al. 2015

Genet. Mol. Res.

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ABSTRACT.To investigate the effect of ammonia (NH 3 ) and humidity on the immune response of broilers, broilers were exposed to 30 or 70 mg/kg atmospheric NH 3 for 21 days. Additionally, birds were exposed to 35, 60, and 85% relative humidity (RH). The relative weights of lymphoid organs, serum total protein, serum globulin, serum albumin, serum lysozyme, proliferation index of peripheral blood lymphocytes, and splenic cytokine gene expression were determined. Exposure to 70 mg/kg NH 3 decreased the relative weight of the spleen during the experimental period, serum lysozyme concentration in the first and second weeks, and serum globulin concentration in the third week. The proliferation of peripheral blood lymphocytes was reduced. High levels of NH 3 caused increase in IL-1β gene expression in the experimental period and IL-4 gene expression in the first week. Birds exposed to 85% RH had lower thymus and bursa of Fabricius weights in the third week and serum lysozyme concentration in the first week; IL-1β and IL-4 expressions were higher in the second and third weeks and first and second weeks, respectively, than in birds exposed to 60% RH. IL-4 expression was lower during the first week, and IL-1β expression was higher during the second week with 35% RH than with 60% RH. In conclusion, high NH 3 level in the poultry house suppressed the immune response of broiler chickens. Neither high nor low RH benefited the immune response of broilers. Furthermore, there was an interactive effect between NH 3 and RH on the immune response of broilers.

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Section: Discussionsupporting

confidence: 93%

Ammonia concentration and relative humidity in poultry houses affect the immune response of broilers

Wei

et al. 2015

Genet. Mol. Res.

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“…This small body of evidence (summarized in Supplemental Table 3) indicates that aflatoxin may cause low hematocrit and hemoglobin,66,67 low iron absorption,68 and microcytic hypochromic anemia,69 all of which are characteristic of iron deficiency.…”

Section: Methodsmentioning

confidence: 99%

Aflatoxin Exposure During Pregnancy, Maternal Anemia, and Adverse Birth Outcomes

Smith

Prendergast

Turner

et al. 2017

The American Society of Tropical Medicine and Hygiene

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Pregnant women and their developing fetuses are vulnerable to multiple environmental insults, including exposure to aflatoxin, a mycotoxin that may contaminate as much as 25% of the world food supply. We reviewed and integrated findings from studies of aflatoxin exposure during pregnancy and evaluated potential links to adverse pregnancy outcomes. We identified 27 studies (10 human cross-sectional studies and 17 animal studies) assessing the relationship between aflatoxin exposure and adverse birth outcomes or anemia. Findings suggest that aflatoxin exposure during pregnancy may impair fetal growth. Only one human study investigated aflatoxin exposure and prematurity, and no studies investigated its relationship with pregnancy loss, but animal studies suggest aflatoxin exposure may increase risk for prematurity and pregnancy loss. The fetus could be affected by maternal aflatoxin exposure through direct toxicity as well as indirect toxicity, via maternal systemic inflammation, impaired placental growth, or elevation of placental cytokines. The cytotoxic and systemic effects of aflatoxin could plausibly mediate maternal anemia, intrauterine growth restriction, fetal loss, and preterm birth. Given the widespread exposure to this toxin in developing countries, longitudinal studies in pregnant women are needed to provide stronger evidence for the role of aflatoxin in adverse pregnancy outcomes, and to explore biological mechanisms. Potential pathways for intervention to reduce aflatoxin exposure are urgently needed, and this might reduce the global burden of stillbirth, preterm birth, and low birthweight.

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“…The findings of this study were in agreement with the results of Aravind et al [32] . In another study, 14% increase for AST and 17% increase for ALT serum levels were observed in chickens fed aflatoxin contaminated diets [33] . One of the symptoms for hyperplasmy is a significant increase in serum levels of ALT and GGT [34] .…”

Section: Discussionmentioning

confidence: 99%

Broiler Tavuklarda Aflatoksin ile Kontamine Diyette Ticari Toksin Bağlayıcı, Doğal Probiyotik Türleri, Maya Hücre Duvarı ve Aluminosilikatın GOT2 ve CYP450 1A5 Gen Ekspresyonları İle Karaciğer Enzimlerinin Serum Konsantrasyonları Üzerine Etkisi

Barati¹,

Chamani²,

Mousavi³

et al. 2017

Kafkas Univ Vet Fak Derg

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Citation of This ArticleBarati M, Chamani M, Mousavi SN, Hoseini SA, Ebrahimi MJA: Effect of commercial toxin binder, native probiotic strains, cell wall yeast and aluminosilicate in diets contaminated with aflatoxin, on the expression of GOT2, CYP450 1A5 genes and serum concentrations of liver enzymes in broiler chickens. Kafkas Univ Vet Fak Derg, 23 (6): 953-960, 2017. DOI: 10.9775/kvfd.2017 AbstractThis study was conducted to investigate the effect of cell wall yeast, aluminosilicate and some probiotic strains in diets contaminated with aflatoxin, on the expression of GOT2, CYP450 1A5 genes and serum concentrations of liver enzymes including GGT, ALT, AST and LDH in broilers. 400 seven-days old chicks from strain Cobb 500 were used as a completely randomized design with 8 treatments, 5 replications.

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Meta-analysis of the relationship of mycotoxins with biochemical and hematological parameters in broilers

Cited by 44 publications

References 17 publications

Ammonia concentration and relative humidity in poultry houses affect the immune response of broilers

Ammonia concentration and relative humidity in poultry houses affect the immune response of broilers

Aflatoxin Exposure During Pregnancy, Maternal Anemia, and Adverse Birth Outcomes

Broiler Tavuklarda Aflatoksin ile Kontamine Diyette Ticari Toksin Bağlayıcı, Doğal Probiyotik Türleri, Maya Hücre Duvarı ve Aluminosilikatın GOT2 ve CYP450 1A5 Gen Ekspresyonları İle Karaciğer Enzimlerinin Serum Konsantrasyonları Üzerine Etkisi

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