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Four hundred broiler chicks were allocated to eight treatments and five replicates in a completely randomized design for 7-42 days. Treatments included basal diet (NC), NC + 1 mg/kg aflatoxin (PC), PC + 1 kg/ton Toxeat® (a toxin binder), PC + Lactobacillus strains (L), PC + Bacillus subtilis JQ 618 strain (B), PC + Saccharomyces cerevisiae's cell wall (Y), PC + B + L + Y (BLY) and PC + hydrated sodium calcium aluminosilicate (HA). At 28 days of age, glucose and total protein serum concentrations in PC group were lower than other treatments (p > .05), but in toxin binder receiving treatments were in the middle of NC and PC groups. At 35 days of age, 48 h after dinitrochlorobenzene injection Y showed more skin swelling (p > .05) and 24 h after injection, the aluminosilicate showed a poor performance with for phytohemagglutinin response. At 35 days, IgG titre and serum cholesterol concentration had a similar process to sheep red blood cell (SRBC) and no significant differences were recorded between aflatoxin inhibitor receiving treatments (p > .05). SRBC, IgG, IgM titres and serum cholesterol concentration at 28 days and IgM titres at 35 days were not affected by treatments (p > .05). It can be concluded that a prebiotics and probiotics mixture such as BLY is suitable for improving immune function and serum biochemical parameters as an effect of feeding aflatoxin-contaminated diet. ARTICLE HISTORY

Citation of This ArticleBarati M, Chamani M, Mousavi SN, Hoseini SA, Ebrahimi MJA: Effect of commercial toxin binder, native probiotic strains, cell wall yeast and aluminosilicate in diets contaminated with aflatoxin, on the expression of GOT2, CYP450 1A5 genes and serum concentrations of liver enzymes in broiler chickens. Kafkas Univ Vet Fak Derg, 23 (6): 953-960, 2017. DOI: 10.9775/kvfd.2017 AbstractThis study was conducted to investigate the effect of cell wall yeast, aluminosilicate and some probiotic strains in diets contaminated with aflatoxin, on the expression of GOT2, CYP450 1A5 genes and serum concentrations of liver enzymes including GGT, ALT, AST and LDH in broilers. 400 seven-days old chicks from strain Cobb 500 were used as a completely randomized design with 8 treatments, 5 replications.