Meta-analysis of the IL-10 promoter polymorphisms and pediatric asthma susceptibility

Zy, Huang; Bj, Cheng; Wan, Yong; Zhou, Chun‐Gao

doi:10.4238/gmr.15028320

Cited by 14 publications

(17 citation statements)

References 26 publications

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“…This result corroborates those obtained by Silva et al [2016] in a systematic literature review on the etiology of MIH, which reported that early childhood disease represents an etiological factor of MIH, in particular fever, asthma, and pneumonia. It is interesting to mention that interleukin family genes have been associated with a greater susceptibility to the development of respiratory diseases [Du et al, 2016;Huang et al, 2016;Hyun et al, 2013;Korytina et al, 2016]. Although the other environment covariates analyzed here were not significantly related with the MIH in the families studied, this does not mean that those environment covariates have no influence in the MIH development.…”

Section: Discussionmentioning

confidence: 44%

“…This result supports our hypothesis that polymorphisms in immune response genes reported as associated with inflammatory diseases considered MIH etiologic factors, such as asthma, ear infections, respiratory tract infections, and allergies [Alaluusua, 2010;Crombie et al, 2009;Silva et al, 2016], may also impact the development of MIH. We highlight the first evidence demonstrated here of the interaction between the rs6654939 SNP in the AMELX gene with the polymorphisms in the IL10 and IL17A, that were reported as risk factors for the development of asthma [Du et al, 2016;Huang et al, 2016] and otitis media [Emonts et al, 2007].…”

Section: Discussionmentioning

confidence: 99%

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Genes Regulating Immune Response and Amelogenesis Interact in Increasing the Susceptibility to Molar-Incisor Hypomineralization

et al. 2018

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Ameloblasts are sensitive cells whose metabolism and function may be affected by inflammatory stimuli. The aim of this study was to evaluate the possible association between polymorphisms in immune response-related genes and molar-incisor hypomineralization (MIH), and their interaction with polymorphisms in amelogenesis-related genes. DNA samples were obtained from 101 nuclear families that had at least 1 MIH-affected child. Eleven single-nucleotide polymorphisms (SNPs) were investigated in immune response genes using TaqMan® technology allele-specific probes. A transmission disequilibrium test was performed to verify overtransmission of alleles in all MIH families, as well as in families only with mild or severe MIH-affected children. Gene-gene interactions between the immune-related and amelogenesis-related polymorphisms were analyzed by determining whether alleles of those genes were transmitted from heterozygous parents more often in association than individually with MIH-affected children. In severe cases of MIH, significant results were observed for rs10733708 (TGFBR1, OR = 3.5, 95% CI = 1.1–10.6). Statistical evidence for gene-gene interactions between rs6654939 (AMELX) and the SNPs rs2070874 (IL4), rs2275913 (IL17A), rs1800872 (IL10), rs1800587 (IL1A), and rs3771300 (STAT1) was observed. The rs2070874 SNP (IL4) was also significantly overtransmitted from heterozygous parents with the rs7526319 (TUFT1) and the rs2355767 (BMP2) SNPs, suggesting a synergistic effect of the transmission of these alleles with susceptibility to MIH. This family-based study demonstrated an association between variation in TGFBR1 and MIH. Moreover, the polymorphisms in immune response and amelogenesis genes may have an additive effect on the risk of developing MIH.

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Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 99%

Genes Regulating Immune Response and Amelogenesis Interact in Increasing the Susceptibility to Molar-Incisor Hypomineralization

et al. 2018

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“…67 Moreover, the same variant was associated with pediatric asthma. 68 In an endemic area for S mansoni, alleles at the 3 promoter SNPs were associated with high tIgE levels in the same direction as in atopic subjects but not with egg counts. IL10 promoter polymorphisms appear to influence nonspecific tIgE levels but not schistosomiasisspecific immunity.…”

Section: Variants That Affect the T H 2 Immune Responsementioning

confidence: 85%

Global issues in allergy and immunology: Parasitic infections and allergy

Cruz

Cooper

Figueiredo

et al. 2017

Journal of Allergy and Clinical Immunology

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Allergic diseases are on the increase globally in parallel with a decrease in parasitic infection. The inverse association between parasitic infections and allergy at an ecological level suggests a causal association. Studies in human subjects have generated a large knowledge base on the complexity of the interrelationship between parasitic infection and allergy. There is evidence for causal links, but the data from animal models are the most compelling: despite the strong type 2 immune responses they induce, helminth infections can suppress allergy through regulatory pathways. Conversely, many helminths can cause allergic-type inflammation, including symptoms of "classical" allergic disease. From an evolutionary perspective, subjects with an effective immune response against helminths can be more susceptible to allergy. This narrative review aims to inform readers of the most relevant up-to-date evidence on the relationship between parasites and allergy. Experiments in animal models have demonstrated the potential benefits of helminth infection or administration of helminth-derived molecules on chronic inflammatory diseases, but thus far, clinical trials in human subjects have not demonstrated unequivocal clinical benefits. Nevertheless, there is sufficiently strong evidence to support continued investigation of the potential benefits of helminth-derived therapies for the prevention or treatment of allergic and other inflammatory diseases.

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“…Two meta‐analyses have been published on the associations between IL‐10 rs1800896 (‐1082A/G), rs1800871 (‐819C/T) or 1800872 (‐592C/A) polymorphisms and asthma . The meta‐analysis published in 2014 comprised 4716 adults and children with asthma and 5093 controls .…”

Section: Discussionmentioning

confidence: 99%

“…The result concerning the IL‐10 rs1800896 polymorphism was in agreement with the observations in the present study. The meta‐analysis published in 2016 comprised 2494 children with asthma and 2160 controls and included nine of the 11 paediatric studies in the 2014 meta‐analysis . The conclusion was that there were no significant associations between the IL‐10 rs1800896, rs1800871 or rs1800872 polymorphisms and susceptibility to paediatric asthma .…”

Section: Discussionmentioning

confidence: 99%

Interleukin‐10 gene polymorphism rs1800896 is associated with post‐bronchiolitis asthma at 11–13 years of age

et al. 2019

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Aim: Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is involved with bronchiolitis and asthma. We evaluated associations between four IL-10 polymorphisms, namely rs1800871, rs1800872, rs1800890 and rs1800896, and post-bronchiolitis asthma in young adolescents. Methods:The cohort consisted of 125 children hospitalised for bronchiolitis at Tampere University Hospital, Finland, in 2000-2004, at less than six months of age. At 11-13 years, asthma diagnoses and asthma-presumptive symptoms, allergic rhinitis and use of inhaled corticosteroids (ICS) were registered. Data on the four polymorphisms and their genotypes, haplotypes and allele frequencies were analysed in relation to asthma, allergic rhinitis and asthma medication.Results: The variant IL-10 rs1800896 genotype was associated with less persistent asthma at five to seven and 11-13 years of age (4.3 versus 15.2%, p = 0.04) than the wild genotype and less ICS use during the previous 12 months (5.4 versus 18.2%, p = 0.03), as was the variant allele G. Allele A was associated with more persistent asthma and ICS use. The significant differences between the variant and wild genotypes were lost in adjusted logistic regression, but the direction of the association remained.Conclusion: IL-10 rs1800896 gene polymorphism was associated with post-bronchiolitis asthma at 11-13 years of age in children hospitalised for bronchiolitis at less than six months of age. 2064

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Meta-analysis of the IL-10 promoter polymorphisms and pediatric asthma susceptibility

Cited by 14 publications

References 26 publications

Genes Regulating Immune Response and Amelogenesis Interact in Increasing the Susceptibility to Molar-Incisor Hypomineralization

Genes Regulating Immune Response and Amelogenesis Interact in Increasing the Susceptibility to Molar-Incisor Hypomineralization

Global issues in allergy and immunology: Parasitic infections and allergy

Interleukin‐10 gene polymorphism rs1800896 is associated with post‐bronchiolitis asthma at 11–13 years of age

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