Meta-analysis of the endogenous N200 latency event-related potential subcomponent in patients with Alzheimer’s disease and mild cognitive impairment

Howe, Aaron

doi:10.1016/j.clinph.2013.10.019

Cited by 34 publications

(22 citation statements)

References 38 publications

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“…We found prolonged N2 latency in the aMCI group compared to the control group. A recent meta-analysis by Howe [100] of ERP studies in MCI and AD patients revealed that N2 latency is a consistent marker of cognitive deterioration, in line with our findings. For instance, Bennys et al [101] found that frontal N2 latency discriminated between MCI and controls in 80% of the cases.…”

Section: Discussionsupporting

confidence: 92%

The Effects of Amnestic Mild Cognitive Impairment on Go/NoGo Semantic Categorization Task Performance and Event-Related Potentials

Mudar

Chiang²,

Eroh³

et al. 2016

JAD

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We examined the effects of amnestic mild cognitive impairment (aMCI) on behavioral (response times and error rates) and scalp-recorded event-related potential (ERP) measures of response execution and inhibition, using Go/NoGo tasks involving basic and superordinate semantic categorization. Twenty-five aMCI (16 F; 68.5±8 years) and 25 age- and gender-matched normal control subjects (16 F; 65.4±7.1 years) completed two visual Go/NoGo tasks. In the single car task, responses were made based on single exemplars of a car (Go) and a dog (NoGo) (basic). In the object animal task, responses were based on multiple exemplars of objects (Go) and animals (NoGo) (superordinate). The aMCI subjects had higher commission errors on the NoGo trials compared to the control subjects, whereas both groups had comparable omission errors and reaction times during the Go trials. The aMCI subjects had significantly prolonged N2 ERP latency during Go and NoGo trials across tasks compared to the controls. Both groups showed similar categorization effects and response type effects in N2/P3 ERP latencies and P3 amplitude. Our findings indicate that altered early neural processing indexed by N2 latency distinguishes subjects with aMCI from controls during the Go/NoGo task. Prolonged Go-N2 latency in aMCI appears to precede behavioral changes in response execution, whereas prolonged NoGo-N2 latency underlies behavioral deterioration in response inhibition.

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Section: Discussionsupporting

confidence: 92%

The Effects of Amnestic Mild Cognitive Impairment on Go/NoGo Semantic Categorization Task Performance and Event-Related Potentials

Mudar

Chiang²,

Eroh³

et al. 2016

JAD

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“…Other recent meta‐analysis showed lower amplitude of P300 in AD patients comparing with healthy controls . The potential N200 is relatively less studied than P300 in patients with MCI and AD, with very different findings . Therefore, there is still a gap of knowledge on this topic.…”

Section: Discussionmentioning

confidence: 99%

“…ERP are sensitive to somatosensory stimulus and therefore can be used to monitor the brain electrical activity, in addition to having no cultural or educational influence and being noninvasive and of low cost . Recent meta‐analyses have demonstrated higher latency and amplitude of P300 and higher N200 latency of MCI or Alzheimer's dementia (AD) patients compared with controls with normal cognition …”

Section: Introductionmentioning

confidence: 99%

“…3 Recent meta-analyses have demonstrated higher latency and amplitude of P300 and higher N200 latency of MCI or Alzheimer 0 s dementia (AD) patients compared with controls with normal cognition. 4,5 There is scant literature analyzing the results on the association of other biomarkers with ERP and the amyloid cascade hypothesis. In fact, only analysis of CSF biomarkers has been found, but without including genetic polymorphisms, functional neuroimaging, or serum biomarkers.…”

Section: Introductionmentioning

confidence: 99%

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Increased N200 and P300 latencies in cognitively impaired elderly carrying ApoE ε‐4 allele

Cintra

Ávila

Soares

et al. 2017

Int J Geriat Psychiatry

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“…Several reports over the past decade described the potential diagnostic importance of electrophysiological markers of cognitive decline in patients with MCI and the preclinical stage of AD, as obtained by analysis of the electroencephalography-derived event-related potentials (ERPs) [20][21][22][23][24][25][26][27][28][29]. For example, the ERP P2, N2, and P3 components are recognized as effective electrophysiological indices in the early stage of MCI diagnosis [20][21][22][23], as MCI subjects have prolonged P2, N2, and P3 latencies, and reduced P3 amplitudes, compared to healthy elderly controls [20,[24][25][26]. Even specific to the MCI subgroups [e.g., amnestic MCI (aMCI)], these ERP components may also be useful for observing the differences in cognitive processes from those of the healthy elderly [20,24,27,28], and to distinguish the different MCI subtypes (e.g., aMCI versus nonaMCI) [29].…”

Section: Introductionmentioning

confidence: 99%

The Role of Physical Fitness in the Neurocognitive Performance of Task Switching in Older Persons with Mild Cognitive Impairment

Tsai

Pai

Ukropec

et al. 2016

JAD

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Abstract. Although elderly people with amnestic mild cognitive impairment (aMCI) have been found to show impaired behavioral performance in task switching, no research has yet explored the electrophysiological mechanisms and the potential correlation between physical fitness and neurocognitive (i.e., behavioral and electrophysiological) performance in aMCI. The present study was thus aimed to examine whether there are differences in electrophysiological (i.e., event-related potential) performance between aMCI participants and controls when performing a task-switching paradigm, and to investigate the role of physical fitness in the relationship between neurocognitive performance and aMCI. Sixty participants were classified into aMCI (n = 30) and control (n = 30) groups, and performed a task-switching paradigm with concomitant electrophysiological recording, as well as underwent senior functional physical fitness tests. The aMCI group showed comparable scores on most parts of the physical fitness tests, but reduced lower body flexibility and VO 2max as compared to the control group. When performing the task-switching paradigm, the aMCI group showed slower reaction times in the heterogeneous condition and larger global switching costs, although no significant difference was observed in accuracy rates between the two groups. In addition, the aMCI group showed significantly prolonged P3 latencies in the homogeneous and heterogeneous conditions, and a smaller P3 amplitude only in the heterogeneous condition. The level of cardiorespiratory fitness was significantly correlated with P3 amplitude in the aMCI group, particularly in the heterogeneous condition of the task-switching paradigm. These results show that the aMCI group exhibited abnormalities in their neurocognitive performance when performing the task-switching paradigm and such a deficit was likely associated with reduced cardiorespiratory fitness, which was shown to be the important predictor of neurocognitive performance.

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Meta-analysis of the endogenous N200 latency event-related potential subcomponent in patients with Alzheimer’s disease and mild cognitive impairment

Cited by 34 publications

References 38 publications

The Effects of Amnestic Mild Cognitive Impairment on Go/NoGo Semantic Categorization Task Performance and Event-Related Potentials

The Effects of Amnestic Mild Cognitive Impairment on Go/NoGo Semantic Categorization Task Performance and Event-Related Potentials

Increased N200 and P300 latencies in cognitively impaired elderly carrying ApoE ε‐4 allele

The Role of Physical Fitness in the Neurocognitive Performance of Task Switching in Older Persons with Mild Cognitive Impairment

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