Meta-analysis of the efficacy and safety of Huanglian Wendan Decoction alone or combined with western medicine in treating insomnia caused by phlegm-heat internal disturbance

Lei, Yuyu; Liyun, H.E.; Xiao, C.H.E.N.; Kaiyue, W.A.N.G.; Yongjun, F.A.N.G.; Zhuang, L.I.A.N.G.; Zhao, Yuan

doi:10.1016/j.dcmed.2022.10.010

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…The respondents answered that herbal medicine treatment was used most frequently in KM, and among the names of the herbal medicine prescriptions, Ondam-tang, Eokgan-san, and Sihogayonggolmororyeo-tang were used to treat ADHD in children and adolescents. Ondam-tang (including modified Ondam-tang, written as Wendan-tang or Wendan decoction in Chinese) has been reported to be effective in treating mental disorders [39,40], including anxiety [41,42], sleep disorders [43], and schizophrenia [44] in East Asian medicine. When prescribing Ondam-tang, different herbs or dosages are used to treat different symptoms, and it is also used by attaching the name of the added herb (ex.…”

Section: Discussionmentioning

confidence: 99%

A National Survey on the Clinical Practice Patterns of Korean Medicine Doctors for Attention Deficit Hyperactivity Disorder (ADHD) in Children and Adolescents

Lee

2023

Children

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To alleviate the symptoms of attention deficit/hyperactivity disorder (ADHD) in children and reduce the side effects of psychostimulants, parents are opting for complementary and alternative medicine as a therapeutic option. Korean medicine (KM) has been used by Korean medicine doctors (KMDs) to treat ADHD with herbal medication and acupuncture. This study aimed to conduct a cross-sectional survey on the clinical practice patterns of KM for ADHD in children targeting KMDs. The questionnaire included aspects related to patient characteristics, diagnosis, treatment modalities, and perceptions regarding KM. Questionnaires were distributed to all KMDs via e-mail, and the online surveys were conducted from 1 to 15 February 2023. A total 2.1% of KMDs (n = 537/25,574) completed the survey. The predominant diagnostic pattern identification employed was “depressed liver qi transforming into fire” (19.8%). Herbal medicine (HM) was the most common treatment (44.2%). The most frequently used HM prescriptions were Ondam-tang (16.9%), Eokgan-san (15.7%), and Sihogayonggolmoryeo-tang (14.4%). KMDs recognized HM as the most effective among the KM treatments (54.3%). The results of this study elucidate the current clinical practice patterns of KM for ADHD. Based on these findings, a treatment protocol can be developed to provide optimized KM treatment services to patients with ADHD.

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Section: Discussionmentioning

confidence: 99%

A National Survey on the Clinical Practice Patterns of Korean Medicine Doctors for Attention Deficit Hyperactivity Disorder (ADHD) in Children and Adolescents

Lee

2023

Children

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“…Ma Xiao [33] et al used a modified Huanglian Wendan decoction to treat metabolic syndrome with phlegm dampness syndrome and found that it could improve the glucose and lipid metabolism function of patients and reduce the level of inflammatory factors. Liu Zijun [34] et al found that serum containing Huanglian Wendan decoction could improve adipocyte insulin resistance of rat adipocytes through the phosphatidylinositol 3 kinase (PI3K) -glucose transporter 4(GLUT4) signaling pathway. Huang Xiuzhen [35] used Huanglian Wendan Decoction and Danzhi Xiaoyao powder to effectively treat type 2 diabetes mellitus complicated with generalized anxiety by soothing the liver and invigorating the spleen, removing heat and eliminating phlegm to achieve both symptoms and root causes.…”

Section: Metabolic Diseasesmentioning

confidence: 99%

Research Progress on Clinical Application of Huanglian Wendan Decoction

2022

IJHPM

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Huanglian Wendan Decoction has achieved satisfactory results in the treatment of multiple systemic diseases in clinical application, including digestive system diseases, cardiovascular system diseases, mental and nervous system diseases, metabolic diseases, etc. [1]. This prescription has the effect of clearing heat and phlegm, removing annoyance and stimulating gallbladder, and reconciling spleen and stomach, so it is mostly used for phlegm, dampness, depression and heat in the above system diseases. In clinical application, we should take syndrome differentiation and treatment as the core, start from the pathogenesis, grasp the essence of the disease, add and subtract with the syndrome, and use flexibly to reflect the idea of "treating different diseases together" in traditional Chinese medicine [2]. In this paper, the relevant literature of Huanglian Wendan Decoction was analyzed and summarized in combination with our own clinical experience, so as to provide beneficial reference for the subsequent development of clinical application of this decoction.Huanglian Wendan Decoction was first recorded in Lu Tingzhen's "Six Reasons and Strips" in the Qing Dynasty. The ingredients of Huanglian Wendan decoction were Coptis Chinensis, Pinellia ternate, Poria cocos, Citri Reticulatae, Pericarpium Aurantii, Fructus, Bambusae Caulis in Taenias, radix glycyrrhizae preparata and Rhizoma Zingiberis Recens. It is derived from the decoction of Wen Dan contained in the Treatise on "Sanyin Ji Yi Bingzheng Fang Lun" by Chen Wuze in Song Dynasty [3](see Table 1). Wendan Decoction opens Yang and adds the pain of Coptis coptitis to reduce the reverse, which strengthens the efficacy of the original recipe in clearing heat, resolving phlegm, and regulating qi[4], and has an obvious effect on qi stagnation and phlegm generation, and the diseases caused by bile stagnation and phlegm disturbance [2]. In the square, coptis is the king, heat and fire, dryness and phlegm; Minister of pinellia, dryness, phlegm, and stomach ; two

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Exploring The Medication Rules And The Mechanism of Action Of Core Drug Pair For Insomnia Based On Data Mining, Network Pharmacology, And Molecular Docking

Guo,

Jiang,

et al. 2024

Preprint

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Meta-analysis of the efficacy and safety of Huanglian Wendan Decoction alone or combined with western medicine in treating insomnia caused by phlegm-heat internal disturbance

Cited by 3 publications

References 16 publications

A National Survey on the Clinical Practice Patterns of Korean Medicine Doctors for Attention Deficit Hyperactivity Disorder (ADHD) in Children and Adolescents

A National Survey on the Clinical Practice Patterns of Korean Medicine Doctors for Attention Deficit Hyperactivity Disorder (ADHD) in Children and Adolescents

Research Progress on Clinical Application of Huanglian Wendan Decoction

Exploring The Medication Rules And The Mechanism of Action Of Core Drug Pair For Insomnia Based On Data Mining, Network Pharmacology, And Molecular Docking

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