Research Progress on Clinical Application of Huanglian Wendan Decoction

Abstract

Huanglian Wendan Decoction has achieved satisfactory results in the treatment of multiple systemic diseases in clinical application, including digestive system diseases, cardiovascular system diseases, mental and nervous system diseases, metabolic diseases, etc. [1]. This prescription has the effect of clearing heat and phlegm, removing annoyance and stimulating gallbladder, and reconciling spleen and stomach, so it is mostly used for phlegm, dampness, depression and heat in the above system diseases. In clinical application, we should take syndrome differentiation and treatment as the core, start from the pathogenesis, grasp the essence of the disease, add and subtract with the syndrome, and use flexibly to reflect the idea of "treating different diseases together" in traditional Chinese medicine [2]. In this paper, the relevant literature of Huanglian Wendan Decoction was analyzed and summarized in combination with our own clinical experience, so as to provide beneficial reference for the subsequent development of clinical application of this decoction.Huanglian Wendan Decoction was first recorded in Lu Tingzhen's "Six Reasons and Strips" in the Qing Dynasty. The ingredients of Huanglian Wendan decoction were Coptis Chinensis, Pinellia ternate, Poria cocos, Citri Reticulatae, Pericarpium Aurantii, Fructus, Bambusae Caulis in Taenias, radix glycyrrhizae preparata and Rhizoma Zingiberis Recens. It is derived from the decoction of Wen Dan contained in the Treatise on "Sanyin Ji Yi Bingzheng Fang Lun" by Chen Wuze in Song Dynasty [3](see Table 1). Wendan Decoction opens Yang and adds the pain of Coptis coptitis to reduce the reverse, which strengthens the efficacy of the original recipe in clearing heat, resolving phlegm, and regulating qi[4], and has an obvious effect on qi stagnation and phlegm generation, and the diseases caused by bile stagnation and phlegm disturbance [2]. In the square, coptis is the king, heat and fire, dryness and phlegm; Minister of pinellia, dryness, phlegm, and stomach ; two