Meta-analysis of the effect of goal-directed therapy on bowel function after abdominal surgery

Gómez-Izquierdo, Juan C.; Feldman, Liane S.; Carli, Franco; Baldini, Gabriele

doi:10.1002/bjs.9747

Cited by 55 publications

(32 citation statements)

References 54 publications

(133 reference statements)

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“…[ 8 ] Previous meta-analysis also showed GDFT was facilitated to bowel function recovery and alleviated gastrointestinal dysfunction after operation. [ 14 , 15 ] Nevertheless, the view has been challenged since more recent evidence has not affirmed these results, especially in field of colorectal surgery. [ 16 – 22 ]…”

Section: Introductionmentioning

confidence: 99%

Goal-directed fluid therapy does not reduce postoperative ileus in gastrointestinal surgery

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Goal-directed fluid therapy does not reduce postoperative ileus in gastrointestinal surgery

et al. 2018

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“…If the patients without flatus for a prolonged time after surgery there can be bloating, intestinal paralysis, intestinal adhesions, and other complications, affect the post-operative diet and bowel functional recovery 17 . Due to the surgical trauma, anesthesia suppression, and other added factors, patients undergoing gastrointestinal surgery have different degrees of gastrointestinal dysfunction, [18][19][20] of which intestinal inflammation induced by operative trauma appears to be the most frequent. 21 Inflammatory infiltration into the intestinal muscularis can lead to hypomotility along the entire gastrointestinal tract 22,23 .…”

Section: Discussionmentioning

confidence: 99%

Chewing Xylitol Gum could Accelerate Bowel motility Recovery after Elective Open Proctectomy for Rectal Cancer

Yang¹,

Long²,

Li³

2018

RIC

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“…[ 8 – 10 ] It is characterized by a series of symptoms such as nausea, vomiting, flatulence, defecation difficulty, abdominal distension, and abdominal pain, which are regarded as inevitable reactions after anesthesia and surgery. [ 11 ] One of the worst complications is delayed resumption of gastrointestinal function, known as postoperative ileus (POI). [ 12 ] This can prolong hospital stays, raise healthcare costs, and increase morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Effect of Yikou-Sizi powder hot compress on gastrointestinal functional recovery in patients after abdominal surgery

et al. 2018

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Background:Postoperative gastrointestinal dysfunction (PGD) is a common complication of patients who have undergone surgery. The clinical manifestations cause great discomfort to postoperative patients and can severely affect postoperative recovery. However, although various pharmacologic agents have been explored for several years, success has been limited. Because some commonly used drugs have caused adverse reactions and because abdominal surgery patients generally cannot consume food or medication during the perioperative period, we were prompted to try an external Chinese medicine treatment method. Yikou-Sizi powder hot compress is an efficient therapy in our hospital, but there is a lack of rigorous studies to certify the safety and effectiveness of its external use to improve gastrointestinal motility. This study aimed to introduce the clinical trial design and test the ability of Yikou-Sizi powder hot compress treatment to accelerate gastrointestinal functional recovery after abdominal surgery.Methods:This study is a randomized controlled clinical trial. The participants will undergo laparoscopic colorectal cancer surgery and laparoscopic total hysterectomy. The primary outcome measure will be the gastrointestinal functional evaluation index, including the time to first passage of flatus, first defecation, first normal bowel sounds, and first consumption of liquid/semigeneral diet foods. According to good clinical practice (GCP), we will evaluate the clinical efficacy and safety of Yikou-Sizi powder hot compress and objectively study the acting mechanism of ghrelin. This pilot trial will be a standard, scientific, and clinical study designed to evaluate the effect of Yikou-Sizi powder hot compress for the recovery of gastrointestinal function after surgery and determine its overall safety.Discussion:This is the first study to describe the use of Yikou-Sizi powder hot compress to accelerate the recovery of gastrointestinal function after abdominal surgery. The study is designed as a randomized, controlled, clinical, large sample size and pilot trial. Evaluation will consist of combining the primary outcome measures with secondary outcome measures to ensure the objectivity and scientific validity of the study. Due to the observational design and the limited follow-up period, it is not possible to evaluate to what extent the connection between the observed improvement and the interventions represents a causal relationship. Efficient comparison between groups will be analyzed by chi-square test.

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Meta-analysis of the effect of goal-directed therapy on bowel function after abdominal surgery

Abstract: GDT facilitated the recovery of bowel function, particularly in patients not treated within enhanced recovery programmes and in those undergoing colorectal operations.

Cited by 55 publications

References 54 publications

Goal-directed fluid therapy does not reduce postoperative ileus in gastrointestinal surgery

Goal-directed fluid therapy does not reduce postoperative ileus in gastrointestinal surgery

Chewing Xylitol Gum could Accelerate Bowel motility Recovery after Elective Open Proctectomy for Rectal Cancer

Effect of Yikou-Sizi powder hot compress on gastrointestinal functional recovery in patients after abdominal surgery

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