Effect of Yikou-Sizi powder hot compress on gastrointestinal functional recovery in patients after abdominal surgery

Abstract

Background:Postoperative gastrointestinal dysfunction (PGD) is a common complication of patients who have undergone surgery. The clinical manifestations cause great discomfort to postoperative patients and can severely affect postoperative recovery. However, although various pharmacologic agents have been explored for several years, success has been limited. Because some commonly used drugs have caused adverse reactions and because abdominal surgery patients generally cannot consume food or medication during the perioperative period, we were prompted to try an external Chinese medicine treatment method. Yikou-Sizi powder hot compress is an efficient therapy in our hospital, but there is a lack of rigorous studies to certify the safety and effectiveness of its external use to improve gastrointestinal motility. This study aimed to introduce the clinical trial design and test the ability of Yikou-Sizi powder hot compress treatment to accelerate gastrointestinal functional recovery after abdominal surgery.Methods:This study is a randomized controlled clinical trial. The participants will undergo laparoscopic colorectal cancer surgery and laparoscopic total hysterectomy. The primary outcome measure will be the gastrointestinal functional evaluation index, including the time to first passage of flatus, first defecation, first normal bowel sounds, and first consumption of liquid/semigeneral diet foods. According to good clinical practice (GCP), we will evaluate the clinical efficacy and safety of Yikou-Sizi powder hot compress and objectively study the acting mechanism of ghrelin. This pilot trial will be a standard, scientific, and clinical study designed to evaluate the effect of Yikou-Sizi powder hot compress for the recovery of gastrointestinal function after surgery and determine its overall safety.Discussion:This is the first study to describe the use of Yikou-Sizi powder hot compress to accelerate the recovery of gastrointestinal function after abdominal surgery. The study is designed as a randomized, controlled, clinical, large sample size and pilot trial. Evaluation will consist of combining the primary outcome measures with secondary outcome measures to ensure the objectivity and scientific validity of the study. Due to the observational design and the limited follow-up period, it is not possible to evaluate to what extent the connection between the observed improvement and the interventions represents a causal relationship. Efficient comparison between groups will be analyzed by chi-square test.

Effect of multimodal preemptive analgesia on postoperative gastrointestinal function and clinical outcome in patients undergoing laparoscopic colorectal surgery

“…Although some strategies have been adopted to accelerate the recovery of gastrointestinal function, POGD is still the main postoperative complication of surgical patients; more than 50% of patients extend the length of hospital stay because of POGD 1,2 . At present, there are many studies on how to prevent POGD 9,16‐19 . We have a further understanding of the mechanism and pathophysiological basis of POGD.…”

“…1,2 At present, there are many studies on how to prevent POGD. 9,[16][17][18][19] We have a further understanding of the mechanism and pathophysiological basis of POGD.…”

Influencing Factors of Gastrointestinal Function Recovery after Gastrointestinal Malignant Tumor

“…Many scholars at home and abroad have conducted in-depth research on the influencing factors of gastrointestinal function recovery. For example, Bozkurt Koseoglu et al found through research that the ERAS concept can not only speed up the recovery of patients after surgery but also improve patients' recovery and quality of life [ 5 ]; Cao et al found that moxibustion is better than Western medicine nursing treatment [ 6 ]; Hu et al found through experiments that acupuncture and moxibustion are helpful for the early recovery of gastrointestinal function after surgery [ 7 ].…”

Abdominal Cerrahi Sonrasında Bağırsak Fonksiyonlarını Artırmada Farmakolojik Olmayan Yöntemlerin Kullanımı: Kanıtlar Ne Diyor?

“…Literatürde konstipasyon sorunu olan erişkin bireylere abdominal ve lomber alana uygulanan sıcak paketlerin bağırsak seslerini ve dışkılama sıklığını artırdığı bildirilmektedir 42 . Abdominal cerrahi geçiren hastalara yapılan sıcak uygulamanın ameliyat sonrası dönemde bağırsak fonksiyonları üzerine etkisinin incelendiği randomize kontrollü klinik çalışmalar sınırlı olup [43][44][45][46][47] konuya ilişkin sistematik derleme ve meta-analiz çalışmasına rastlanmamıştır.…”

“…Abdominal cerrahi geçiren hastalarda sıcak uygulamanın bağırsak hareketleri üzerine etkisini belirlemek amacıyla geliştirilen bir randomize kontrollü çalışma protokolünde; sıcak kompres uygulamasının ameliyat sonrası birinci günden başlanarak ilk defekasyon süresine kadar ve günde iki kez (saat 9:00-16:00) uygulanması planlanmıştır 44 43 . Bir başka çalışmada ise sezaryen doğum sonrası 3. saatte sıcak su ayak banyosu uygulamasının kadınların gaz çıkarma süresini etkilemediği, ancak gaz çıkarma süresini kontrol grubuna göre daha kısalttığı belirlenmiştir 46 .…”