Meta-Analysis of Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure Patients Without Diabetes

Mohamed, Mohamed M G; Shaikh, Safia; Kheiri, Babikir

doi:10.1016/j.amjcard.2021.03.001

Cited by 1 publication

(2 citation statements)

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“…This is particularly relevant in resource-limited settings when patients with limited access to insulin and healthcare systems due to financial constraints present in severe ketoacidosis. The risk of DKA is also increased in patients with renal failure, during pregnancy, and in patients during fasting. , Sodium-glucose cotransporter-2 inhibitors have emerged as a highly effective treatment in patients with diabetes and heart failure with benefits on glycemia, renal function, cardiovascular outcomes, and all-cause mortality. , However, of concern, they have been associated with a twofold increase in the risk of developing ketoacidosis …”

Section: Introductionmentioning

confidence: 99%

“…2,3 Sodium-glucose cotransporter-2 inhibitors have emerged as a highly effective treatment in patients with diabetes 4 and heart failure 5 with benefits on glycemia, renal function, 6 cardiovascular outcomes, and allcause mortality. 7,8 However, of concern, they have been associated with a twofold increase in the risk of developing ketoacidosis. 9 The conventional method used to detect ketoacidosis requires a blood sample and access to a laboratory to measure the concentration of serum β-hydroxybutyrate.…”

Section: Introductionmentioning

confidence: 99%

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Breath Analysis for the In Vivo Detection of Diabetic Ketoacidosis

et al. 2022

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Human breath analysis of volatile organic compounds has gained significant attention recently because of its rapid and noninvasive potential to detect various metabolic diseases. The detection of ketones in the breath and blood is key to diagnosing and managing diabetic ketoacidosis (DKA) in patients with type 1 diabetes. It may also be of increasing importance to detect euglycemic ketoacidosis in patients with type 1 or type 2 diabetes or heart failure, treated with sodium-glucose transporter-2 inhibitors (SGLT2-i). The present research evaluates the efficiency of colorimetry for detecting acetone and ethanol in exhaled human breath with the response time, pH effect, temperature effect, concentration effect, and selectivity of dyes. Using the proposed multidye system, we obtained a detection limit of 0.0217 ppm for acetone and 0.029 ppm for ethanol in the detection range of 0.05−50 ppm. A smartphone-assisted unit consisting of a portable colorimetric device was used to detect relative red/green/blue values within 60 s of the interface for practical and real-time application. The developed method could be used for rapid, low-cost detection of ketones in patients with type 1 diabetes and DKA and patients with type 1 or type 2 diabetes or heart failure treated with SGLT2-I and euglycemic ketoacidosis.

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