Meta-analysis of data from human ex vivo placental perfusion studies on genotoxic and immunotoxic agents within the integrated European project NewGeneris

Mose, Tina; Mathiesen, Line; Karttunen, Vesa; Nielsen, Jeanette K.; Sieppi, Elina; Kummu, Maria; Mørck, Thit Aarøe; Myöhänen, Kirsi; Partanen, Heidi; Vähäkangas, Kirsi; Knudsen, Lisbeth E.; Myllynen, Päivi

doi:10.1016/j.placenta.2012.02.004

Cited by 38 publications

(17 citation statements)

References 32 publications

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“…Upon ingestion or inhalation by pregnant women, many environmental carcinogens are capable of crossing the placental barrier and reaching the fetus (9). It has been shown that the placental barrier does not protect the unborn child in case of maternal exposure to acrylamide, dioxins, and estrogen-like compounds such as organochlorine pesticides and amphenones (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Global Gene Expression Analysis in Cord Blood Reveals Gender-Specific Differences in Response to Carcinogenic Exposure In Utero

Hochstenbach

Leeuwen

Gmuender

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: It has been suggested that fetal carcinogenic exposure might lead to predisposition to develop cancer during childhood or in later life possibly through modulation of the fetal transcriptome. Because gender effects in the incidence of childhood cancers have been described, we hypothesized differences at the transcriptomic level in cord blood between male and female newborns as a consequence of fetal carcinogenic exposure. The objective was to investigate whether transcriptomic responses to dietary genotoxic and nongenotoxic carcinogens show gender-specific mechanisms-of-action relevant for chemical carcinogenesis.Methods: Global gene expression was applied in umbilical cord blood samples, the CALUX-assay was used for measuring dioxin(-like), androgen(-like), and estrogen(-like) internal exposure, and acrylamide-hemoglobin adduct levels were determined by mass spectrometry adduct-FIRE-procedure TM . To link gene

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Section: Introductionmentioning

confidence: 99%

Global Gene Expression Analysis in Cord Blood Reveals Gender-Specific Differences in Response to Carcinogenic Exposure In Utero

Hochstenbach

Leeuwen

Gmuender

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Mose et al [8] studied the BPA trans-placental transfer rate in human placentas in ex vivo experiments. Results led the authors to conclude that free BPA can cross the placenta by passive difusion with a trans-placental transfer rate of 1 (e.g., the concentration in the fetal blood was equal to the concentration in the blood of the mother), as previously demonstrated by Balakrishnan et al [9].…”

Section: Type Of Food Productmentioning

confidence: 99%

Bisphenol A in Chronic Kidney Disease

Palladino¹,

Sereni²

2017

Bisphenol a Exposure and Health Risks

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Several types of medical devices are produced using polycarbonate (PC) polymer. Unfortunately, these medical devices produced using PC could contain and release Bisphenol A (BPA) residual in routinely use. Published evidence on BPA in dialysis or Chronic Kidney patients (CKD) is scarce and limited to the observation of increased blood BPA levels. Increased serum BPA with decreasing renal function was observed in a smaller study of 32 CKD patients, suggesting that BPA may accumulate. Recently a crossover study evaluated the impact of the choice of dialyzer (BPA-free versus BPAcontaining) on serum and intracellular BPA levels and on inlammation and oxidative stress markers. Currently, BPA is still considered, from regulatory agencies, safe enough in the general population, despite several red lags, as it is readily excreted in the urine. However, patients in End Stage Renal Disease (ESRD) are unable to excrete BPA in their urine, leading to BPA accumulation. Repeated loading of BPA during hemodialysis with BPA-containing membranes may aggravate the problem due to migration of BPA from dialyzers to the blood of patients. In contrast, some recent studies on the chronic use of BPA-free dialyzers, results in decreased BPA levels.

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“…For instance, N-Nitrosodimethylamine, alcohol, acrylamide, glycidamine, 2-amino-3-methylimidazo [4,5-f] quinoline, and bisphenol A have been shown to have a high rate of transfer via the placenta. 5,6 Exposure to a variety of agents during pregnancy can have toxic effects on children. For instance, maternal diets high in dioxins have been found to contribute to fetal exposure to dioxins and may contribute to reduced birth weight 7 and the effects of prenatal exposure to lead are well documented.…”

Section: P R E N a T A L A N D E A R L Y L I F E : S E T T I N G T H mentioning

confidence: 99%

Health Consequences of Environmental Exposures in Early Life: Coping with a Changing World in the Post-MDG Era

Suk

Ruchirawat

Stein

et al. 2016

Annals of Global Health

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Despite overall progress toward achieving the Millennium Development Goals, large health discrepancies persist between developed and developing countries. The world is rapidly changing and the influences of societal change and climate change will disproportionately affect the world's most vulnerable populations, thus exacerbating current inequities. Current development strategies do not adequately address these disproportionate impacts of environmental exposures. The aim of this study was to propose a new framework to address the health consequences of environmental exposures beyond 2015. This framework is transdisciplinary and precautionary. It is based on identifying social and economic determinants of health, strengthening primary health systems, and improving the health of vulnerable populations. It incorporates deliberate plans for assessment and control of avoidable environmental exposures. It sets specific, measurable targets for health and environmental improvement.

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Meta-analysis of data from human ex vivo placental perfusion studies on genotoxic and immunotoxic agents within the integrated European project NewGeneris

Cited by 38 publications

References 32 publications

Global Gene Expression Analysis in Cord Blood Reveals Gender-Specific Differences in Response to Carcinogenic Exposure In Utero

Global Gene Expression Analysis in Cord Blood Reveals Gender-Specific Differences in Response to Carcinogenic Exposure In Utero

Bisphenol A in Chronic Kidney Disease

Health Consequences of Environmental Exposures in Early Life: Coping with a Changing World in the Post-MDG Era

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