Global Gene Expression Analysis in Cord Blood Reveals Gender-Specific Differences in Response to Carcinogenic Exposure <i>In Utero</i>

Hochstenbach, Kevin; Leeuwen, Danitsja D.M. Van; Gmuender, Hans; Gottschalk, Ralf R.W.; Løvik, Martinus; Granum, Berit; Nygaard, Unni Cecilie; Kirsch‐Volders, Micheline; Decordier, Ilse; Loock, Kim Vande; Besselink, Harrie; Törnqvist, Margareta; Stedingk, Hans von; Rydberg, Per; Kleinjans, Jos; Loveren, Henk Van; Delft, Joost J.H.M. Van

doi:10.1158/1055-9965.epi-12-0304

Cited by 38 publications

(30 citation statements)

References 49 publications

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“…Furthermore, gene expression network analysis was used to identify gene expression patterns associated with micronuclei formation under different environmental exposure conditions such as acrylamide or nitrosamine exposure (444,445). A similar approach could be developed to identify gene expression networks that relate to folate deficiencyinduced uracil misincorporation, DNA hypomethylation, and micronuclei and possibly also include folate deficiency-specific microRNAs (e.g., miR-222) in the diagnostics (446).…”

Section: Research Gaps and Needsmentioning

confidence: 99%

Biomarkers of Nutrition for Development—Folate Review

Lynch¹,

Pfeiffer

Georgieff

et al. 2015

The Journal of Nutrition

641

412

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The Biomarkers of Nutrition for Development (BOND) project is designed to provide evidence-based advice to anyone with an interest in the role of nutrition in health. Specifically, the BOND program provides state-of-the-art information and service with regard to selection, use, and interpretation of biomarkers of nutrient exposure, status, function, and effect. To accomplish this objective, expert panels are recruited to evaluate the literature and to draft comprehensive reports on the current state of the art with regard to specific nutrient biology and available biomarkers for assessing nutrients in body tissues at the individual and population level. Phase I of the BOND project includes the evaluation of biomarkers for 6 nutrients: iodine, iron, zinc, folate, vitamin A, and vitamin B-12. This review represents the second in the series of reviews and covers all relevant aspects of folate biology and biomarkers. The article is organized to provide the reader with a full appreciation of folate's history as a public health issue, its biology, and an overview of available biomarkers (serum folate, RBC folate, and plasma homocysteine concentrations) and their interpretation across a range of clinical and population-based uses. The article also includes a list of priority research needs for advancing the area of folate biomarkers related to nutritional health status and development.

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Section: Research Gaps and Needsmentioning

confidence: 99%

Biomarkers of Nutrition for Development—Folate Review

Lynch¹,

Pfeiffer

Georgieff

et al. 2015

The Journal of Nutrition

641

412

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“…In a substudy of the Norwegian Mother and Child Cohort (the BraMat cohort), umbilical blood cord samples of 45 male and 66 female newborn children were investigated (Hochstenbach et al, 2012). Eighty-four per cent of the mothers were non-smokers.…”

Section: Effects On Gene Expressionmentioning

confidence: 99%

Scientific Opinion on acrylamide in food

Publication¹

2015

EFS2

332

170

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EFSA was asked to deliver a scientific opinion on acrylamide (AA) in food. AA has widespread uses as an industrial chemical. It is also formed when certain foods are prepared at temperatures above 120 °C and low moisture, especially in foods containing asparagine and reducing sugars. The CONTAM Panel evaluated 43 419 analytical results from food commodities. AA was found at the highest levels in solid coffee substitutes and coffee, and in potato fried products. Mean and 95th percentile dietary AA exposures across surveys and age groups were estimated at 0.4 to 1.9 µg/kg body weight (b.w.) per day and 0.6 to 3.4 µg/kg b.w. per day, respectively. The main contributor to total dietary exposure was generally the category 'Potato fried products (except potato crisps and snacks)'. Preferences in home-cooking can have a substantial impact on human dietary AA exposure. Upon oral intake, AA is absorbed from the gastrointestinal tract and distributed to all organs. AA is extensively metabolised, mostly by conjugation with glutathione but also by epoxidation to glycidamide (GA). Formation of GA is considered to represent the route underlying the genotoxicity and carcinogenicity of AA. Neurotoxicity, adverse effects on male reproduction, developmental toxicity and carcinogenicity were identified as possible critical endpoints for AA toxicity from experimental animal studies. The data from human studies were inadequate for dose-response assessment. The CONTAM Panel selected BMDL 10 values of 0.43 mg/kg b.w. per day for peripheral neuropathy in rats and of 0.17 mg/kg b.w. per day for neoplastic effects in mice. The Panel concluded that the current levels of dietary exposure to AA are not of concern with respect to non-neoplastic effects. However, although the epidemiological associations have not demonstrated AA to be a human carcinogen, the margins of exposure (MOEs) indicate a concern for neoplastic effects based on animal evidence. © European Food SUMMARYFollowing a request from the European Commission, the Panel on Contaminants in the Food Chain (CONTAM Panel) was asked to deliver a scientific opinion on acrylamide (AA) in food. The Panel developed the draft scientific opinion which underwent a public consultation from 1 July 2014 to 15 September 2014. The comments received and how they were taken into account when finalising the scientific opinion were published in an EFSA Technical Report (EFSA, 2015).AA is a low molecular weight, highly water soluble, organic compound. It is used inter alia as an industrial chemical and in the production of polyacrylamides. Heightened concerns about exposure to AA arose in 2002 when it was discovered that it forms when certain foods are prepared at temperatures usually above 120 °C and low moisture. It forms, at least in part, due to a Maillard reaction between certain amino acids, such as asparagine, and reducing sugars. However, several other pathways and precursors have also been proposed to contribute to AA formation. AA forms in numerous baked or fried carbohydrate-rich f...

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“…Male newborns showed a higher number of genes significantly correlating with MN frequencies, when compared to female newborns (1397 vs 95) and, only in males, acrylamide and glycidamide haemoglobin adducts correlated significantly with MN frequencies (Hochstenbach et al, 2012).…”

Section: Imstar Pathfinder Tm Screentox Auto-mnmentioning

confidence: 78%

“…In the context of the NewGeneris project, the MN scoring data obtained with the IMSTAR Pathfinder TM Screentox Auto-MN system, were reported for single cohorts, in Crete and Norway (Hochstenbach et al, 2012). Cytologists of the different cohorts were trained at the VUB laboratory, to harmonize the slide preparation protocols.…”

Section: Imstar Pathfinder Tm Screentox Auto-mnmentioning

confidence: 99%