Meta-Analysis of Association of Obstructive Sleep Apnea With Glaucoma

Liu, Shulin; Lin, Yu Hui; Liu, Xin

doi:10.1097/ijg.0000000000000357

Cited by 60 publications

(44 citation statements)

References 20 publications

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“…32 In contrast a meta-analysis involving 2 288 701 participants shows that OSA is a risk factor for glaucoma, higher in Chinese population, female or younger population. 33 Our study also found an increase prevalence in patients with severe AHI, exploring the relationship of the severity of OSA, as suggested in this meta-analysis. There was no difference in POAG prevalence in the general Italian and our study cohort.…”

Section: Discussionsupporting

confidence: 76%

Prevalence and risk factors of eye diseases in adult patients with obstructive sleep apnoea: results from the SLE.E.P.Y cohort study

et al. 2017

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ObjectivesTo assess the occurrence of glaucoma, eyelid, corneal and macular disorders in a cohort of patients with obstructive sleep apnoea (OSA) diagnosed by overnight polysomnography and to investigate into the risk factors for the above eye diseases (EDs).DesignCross-sectional cohort study between 2014 and 2015.SettingUnit of Respiratory Medicine and Eye Clinic of the University of Verona.Participants431 consecutive patients were considered eligible. Of these, 87 declined to participate, 35 were untraceable and 13 were deceased.InterventionsA complete ophthalmic evaluation of both eyes for each patient.Primary and secondary outcome measuresBest-corrected distance visual acuity, intraocular pressure, corneal, macular and optic nerve optical coherence tomography, ocular aberrometry, optic nerve laser polarimetry, visual field test, and eyelid examination.Results296 patients aged 64.5±12.8 years, 23% female and 77% male, underwent ophthalmic examination. There was 56% (n=166) prevalence of eyelid disorders, 27% (n=80) of corneal disorders, 13% (n=39) of macular disorders and 11% (n=33) of glaucoma. Advancing age was not associated with the severity of OSA, while significant differences were found for gender, body mass index, Oxygen Desaturation Index, smoking habit, hypertension and diabetes. Severe OSA was significantly associated with glaucoma (OR, 95% CI 1.05 to 5.93, p=0.037).ConclusionsEDs were more prevalent in our patinets with OSA than in the general population. Severe Apnoea/Hypopnoea Index level seemed to play a role as risk factor only for glaucoma.

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Section: Discussionsupporting

confidence: 76%

Prevalence and risk factors of eye diseases in adult patients with obstructive sleep apnoea: results from the SLE.E.P.Y cohort study

et al. 2017

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“…Inflation bias or “p‐hacking” was tested with a P‐curve analysis . Post hoc sensitivity analysis was conducted to evaluate the influence of a single study on the overall effect estimate by stepwise omitting, one by one, each of the studies included in the meta‐analysis and re‐evaluating the summary effect estimates . Post hoc analysis was conducted on study design.…”

Section: Methodsmentioning

confidence: 99%

What is the effect of active ingredients in dentifrice on inhibiting the regrowth of overnight plaque? A systematic review

Valkenburg

Slot

Weijden

2019

Int J Dental Hygiene

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Objectives:The aim of this systematic review was to establish the adjuvant clinical effect of brushing with a dentifrice containing purported active ingredients as compared to a regular sodium fluoride dentifrice with respect to the inhibition of overnight dental plaque regrowth from studies with human participants.Methods: MEDLINE-PubMed, EMBASE and Cochrane CENTRAL were searched, up to June 2019. The inclusion criteria were controlled clinical trials with participants aged ≥ 18 years in good general health. Studies were included that evaluated the effect of toothbrushing with a dentifrice on the inhibition of overnight dental plaque regrowth when an active ingredient was added to the dentifrice as compared to a common sodium fluoride product. Data were extracted from the eligible studies, the risk of bias was assessed, and a meta-analysis was performed where feasible.Result: Independent screening of 213 unique papers resulted in 10 eligible publications that provided 14 comparisons. Stannous fluoride and triclosan dentifrices were found as the active ingredients. The descriptive analysis indicated that all, but two comparisons demonstrated an additional effect on the active-ingredient dentifrice.The meta-analysis supported and strengthened these findings. It showed that when plaque was scored digitally, a DiffM was −3.15(95% CI [−4.61:-1.69], P < .001, prediction interval [−5.07;-1.24]). When plaque was scored clinically, the difference of means (DiffM) was −0.33(95% CI [−0.49:-0.16], P < .001, prediction interval [−0.87; 0.21]). Conclusion:The results of this review demonstrate moderate-quality evidence that brushing with an active-ingredient dentifrice with stannous fluoride or triclosan does provide an added clinically relevant effect concerning plaque inhibition capabilities that surpass the effect of a regular sodium fluoride dentifrice. K E Y W O R D S dentifrice, oral hygiene, plaque, plaque inhibition, plaque regrowth, systematic review, toothbrushing, toothpaste | 129 VALKENBURG Et AL. S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Valkenburg C, Else Slot D, Van der Weijden GA. What is the effect of active ingredients in dentifrice on inhibiting the regrowth of overnight plaque? A systematic review. Int J Dent Hygiene. 2020;18:128-141.

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“…OSA predisposes the optic nerve head to ischemia and damage through episodes of hypoxia, hemodynamic changes to retinal blood vessels, oxidative stress, mitochondrial dysregulation, and inflammation. 18,20,21 This proclivity to damage leads to the nerve fiber dysfunction and degeneration seen in glaucoma. Patients with OSA may possess optic nerve heads more sensitive to mechanical damage given their poor perfusion and potential for ischemic changes.…”

Section: G L Auco M Amentioning

confidence: 99%

“…The exact etiology remains unclear. 16 Studies have demonstrated an association with OSA and both NTG and OAG. 5,9,17 A meta-analysis of 3 case-control studies, including 711 cases and 6,709 controls, found an odds ratio (OR) of 2.46 for the association between OSA and glaucoma.…”

Section: G L Auco M Amentioning

confidence: 99%

Ocular Manifestations of Obstructive Sleep Apnea

Santos

Hofmann

2017

Journal of Clinical Sleep Medicine

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Study Objectives: Obstructive sleep apnea (OSA) incurs a host of systemic side effects. The eyes are particularly susceptible to both mechanical and vascular sequelae of the disease. This paper outlines the ocular manifestations of sleep apnea. The authors hope to increase awareness of the ocular complications of this common disorder and increase communication and co-management between eye-care providers and sleep specialists alike. Methods: Data were collected from PubMed and the Brown University Library Collection. Results: Twenty-two papers were included in this review to address floppy eyelid syndrome, nonarteritic anterior ischemic optic neuropathy, central serous retinopathy, retinal vein occlusion, and glaucoma. We used three meta-analyses and several cross-sectional cohort and case-control studies that investigate the aforementioned conditions and their associations with OSA. Conclusions: Hypoxia induced by nightly cessation of breathing increases patients' risk of coronary artery disease, heart failure, stroke, and other conditions. As with many maladies detrimental to vascular health, obstructive sleep apnea affects the eye and ocular adnexa. This paper summarizes the current evidence implicating OSA in these ocular maladies and highlights their proposed mechanisms. The authors describe ocular pathology which sleep specialists may encounter. We encourage more aggressive attention to ocular symptoms in patients with sleep apnea to prevent vision-threatening complications. Further research should investigate how sleep apnea treatment affects these ocular findings and identify which sleep apnea patients are most prone to developing ocular pathology. Keywords: eye diseases, obstructive sleep apnea, ophthalmology Citation: Santos M, Hofmann RJ. Ocular manifestations of obstructive sleep apnea.

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Meta-Analysis of Association of Obstructive Sleep Apnea With Glaucoma

Abstract: OSA was a risk factor for glaucoma. A large number of studies is needed to explore the mechanisms that link OSA with glaucoma.

Cited by 60 publications

References 20 publications

Prevalence and risk factors of eye diseases in adult patients with obstructive sleep apnoea: results from the SLE.E.P.Y cohort study

Prevalence and risk factors of eye diseases in adult patients with obstructive sleep apnoea: results from the SLE.E.P.Y cohort study

What is the effect of active ingredients in dentifrice on inhibiting the regrowth of overnight plaque? A systematic review

Ocular Manifestations of Obstructive Sleep Apnea

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