Meta-analysis of association between il-6-174 g/c polymorphism and female infertility related disorders

Benjamin, Jiby Jolly; Koshy, Teena; Kumar, K. Mahesh; Maruthy, K N; Padmavathi, R

doi:10.1016/j.jri.2020.103134

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…As these studies did not depict clear association in any direction, a systematic review and meta-analysis was purposed to study the association of DHEA with PCOS from the existing body of evidence. Similar meta-analyses were also done to find the association of inflammatory genes with female infertility disorders [ 14 ] as well as cortisol with PCOS [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies

et al. 2021

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Background Polycystic ovarian syndrome is a heterogenous endocrine disorder characterized by irregular menstrual cycles, hirsuitism and polycystic ovaries. It is further complicated by metabolic syndrome, infertility and psychological stress. Although the etiopathogenesis is unclear, many studies have pointed out the role of stress in this syndrome. DHEA, being a stress marker is being used by scientists to compare the stress levels between polycystic ovarian cases and healthy controls. However, the results obtained from previous studies are equivocal. Objective To perform meta-analysis and find the association between stress and the syndrome. Data sources Relevant data till January 2021 were retrieved from PubMed, Scopus, Embase and Web of Science using MeSH terms. Study selection Case-control studies having PCOS subjects as cases and healthy women as controls were selected provided; their basal DHEA levels were mentioned in the published articles. Data extraction Two authors independently extracted the articles and qualified the final studies. Data synthesi Pooled meta-analysis was done using random effect model and showed level of DHEA statistically significant in PCOS compared to healthy controls (SMD = 1.15, 95% CI = 0.59–1.71).Heterogeneity was statistically significant as well (I2 = 95%). Conclusion Thismeta-analysis on DHEA and PCOS has helped in generating evidence regarding the involvement of stress in the pathogenesis of PCOS.

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Section: Introductionmentioning

confidence: 99%

DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies

et al. 2021

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“…On infertile couples, it was reported that 48.8 % of infertility cases were only of female origin, and 52.1% of them were caused by ovular problems (41). Genetic, environmental, lifestyle, and metabolic factors are associated with infertility in women (42)(43)(44)(45)(46). Many factors such as environmental pollution, heavy metals, chemicals and pesticides, extreme heat, smoking, alcohol, caffeine, some drugs, stress, socioeconomic factors, radiation, disruption of circadian rhythm, obesity, microbiota, thyroid problems, insulin resistance, and eating disorders have been associated with infertility in women (42,43,47).…”

Section: Woman Infertilitymentioning

confidence: 99%

Diyet ileri glikasyon son ürünleri (AGE) ve kadın infertilitesi

ÇELİK,

AKDEVELİOĞLU

2023

SBGY

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Advanced glycation end products (AGEs) are molecules formed by non-enzymatic reactions between reducing sugars and proteins, nucleic acids, or lipids. Advanced glycation end products may be formed endogenously under normal metabolic conditions or metabolic conditions such as diabetes and hyperglycemia, or exogenously during processing of foods at high temperatures and low humidity, including roasting, grilling, and frying. The accumulation of AGEs has a significant role in the development of disorders associated with infertility. Infertility is an increasingly common health problem in recent years. Dietary habits and nutrient intake are among the many factors affecting infertility in women. Receptor AGEs (RAGE) and AGEs have been observed in theca and granulosa cells of the ovaries. High levels of AGEs affect fertility through ovarian dysfunction, follicular growth, oocyte number, fertilization rate, embryo development, adverse effects on pregnancy rate, insulin resistance, apoptosis, endothelial dysfunction, increased inflammation, and reactive oxygen species (ROS). This review aims to investigate the pathophysiology of AGEs and their receptors, as well as their possible implications for female reproductive health.

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