Meta‐analysis of alcohol consumption and risk of extrahepatic bile system cancer

Kan, Heping; Huang, Yuqi; Tan, Yuxiang; Zhou, Jie

doi:10.1111/j.1872-034x.2011.00831.x

Cited by 9 publications

(6 citation statements)

References 34 publications

(101 reference statements)

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“…14 An OR of less than 1 reflects a favorable outcome in the statin use compared with non-use and indicates lower morbidity rate, and vice versa. 15 According to the heterogeneity, both the fixed-effects model (weighted with inverse variance) and the random-effects model were considered for the metaanalyses. The Mantel-Haenszel fixed-effects model was first used to pool OR.…”

Section: Discussionmentioning

confidence: 99%

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Statin use and risk of gallstone disease: A meta‐analysis

Kan

Guo

Tan

et al. 2014

Hepatology Research

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Section: Discussionmentioning

confidence: 99%

“…Before pooling the data, the adjusted OR abstracted from individual studies were transformed to their log (OR) to stabilize the variances and normalize the distribution . An OR of less than 1 reflects a favorable outcome in the statin use compared with non‐use and indicates lower morbidity rate, and vice versa …”

Section: Methodsmentioning

confidence: 99%

Statin use and risk of gallstone disease: A meta‐analysis

Kan

Guo

Tan

et al. 2014

Hepatology Research

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“…Interestingly, few studies reported a protective effect of moderate alcohol consumption against cholangiocarcinoma. A meta-analysis done by Kan et al [49] showed moderate alcohol consumption was associated with a lower risk of ECC. Similarly, Shaib et al [50] in a case-control study reported mild or moderate alcohol consumption was associated with a lower risk of ECC, whereas heavy alcohol consumption (defined as 80 g of ethanol per day or more) was associated with increased risk of ECC.…”

Section: Alcohol and Cholangiocarcinomamentioning

confidence: 99%

Controversial risk factors for cholangiocarcinoma

Baidoun¹,

Sarmini

Merjaneh³

et al. 2021

European Journal of Gastroenterology &Amp; Hepatology

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We did a cross-section study using the National Inpatient Sample (NIS) database between 2011 and 2015. The NIS database is the largest all-payer inpatient database in the United States and contains a sample of over eight million inpatient hospitalizations each year, which represents about 20% of all the discharges from all community hospitals participating in the Healthcare Cost and Utilization Project (HCUP). It excludes rehabilitation and long-term acute care hospitals. Each record of the NIS data includes up to 25 primary and secondary diagnoses in addition to up to 15 primary and secondary procedures. It also has the patient demographics, discharge status, length of stay, disease severity and comorbidity measures. Study population, inclusion and exclusion criteriaAll adult patients (≥18 years old) from the NIS database between 2011 and 2015 were included. Using the International Classification of Diseases 9th version (ICD-9) code, we identified all records with cholangiocarcinoma using the appropriate codes. We identified patients' demographics using the Clinical Classification Software codes provided by the HCUP and appropriate ICD-9 codes. Using appropriate ICD-9 codes and Elixhauser comorbidity, we also identified the comorbidities of interest as shown in Supplementary Table 1 and 2, Supplemental digital Introduction Cholangiocarcinoma is a rare malignancy accounting for 3% of gastrointestinal cancers in the USA. While multiple risk factors for cholangiocarcinoma are established, other potential risk factors are still controversial. Herein, we used a large national database to investigate possible risk factors and associations. Method We used the National Inpatient Sample database to review all admissions between 2011 and 2015. We grouped patients based on the presence and absence of cholangiocarcinoma. Using multivariate logistic regression analysis, we assessed the association between obesity, alcohol abuse, smoking, diabetes mellitus and cholangiocarcinoma. Results Out of 30 9552 95 admissions, 20 030 had cholangiocarcinoma. Cholangiocarcinoma patients were older (67 ± 12.8 vs. 57 ± 20.6; P < 0.001) and had fewer female patients (48 vs. 59%; P < 0.001). Multivariate logistic regression analysis showed that diabetes mellitus was associated with cholangiocarcinoma (OR, 1.04; 95% CI, 1.01-1.08; P < 0.001). On the other hand, alcohol, smoking and obesity were all inversely associated with cholangiocarcinoma (OR, 0.75; 95% CI, 0.69-0.81; P < 0.001), (OR, 0.75; 95% CI, 0.71-0.79; P < 0.001) and (OR, 0.71; 95% CI, 0.67-0.75; P < 0.001), respectively. In addition, compared to Whites, Hispanic and Asian/Pacific Islander races were more associated with cholangiocarcinoma (OR, 1.27; 95% CI, 1.21-1.34) and (OR, 1.79; 95% CI, 1.67-1.92) (P < 0.001 for all), respectively, whereas African American race was inversely associated with cholangiocarcinoma (OR, 0.85; 95% CI, 0.81-0.89; P < 0.001). Conclusion Patients with a diagnosis of diabetes mellitus or from certain ethnic groups (Hispanic and Asian/Pacific Islander) ar...

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“…Alcoholic beverage has been widely consumed and its global consumption has been increasing in the last decades (World Health Organization, 2002). Merits and demerits of alcoholic beverage intake have been long explored because of its benefit for cardiovascular disease (Corrao et al , 2000; Fillmore et al , 2007; Ronksley et al , 2011) or carcinogenic effect (Kan et al , 2011). An International Review panel, sponsored by the World Cancer Research Fund (WCRF) and American Institute for Cancer Research, reported that alcoholic beverage intake increased the risk of cancers of the oral cavity, larynx, pharynx, oesophagus, liver, female breast, and colorectum (World Cancer Research Fund & American Institute for Cancer Research, 2007), but there was a limited evidence about the association between alcoholic beverage intake and kidney cancer.…”

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confidence: 99%

Alcohol intake and renal cell cancer risk: a meta-analysis

Song

Song³

et al. 2012

Br J Cancer

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Background:An inverse association between alcoholic beverage intake and risk of renal cell cancer has been suggested in recent studies.Methods:We examined the association between alcoholic beverages and renal cell cancer risk in a meta-analysis. We identified relevant studies by searching the database of PubMed, EMBASE, and MEDLINE published through August 2011. We combined the study-specific relative risks (RRs) using a random-effects model.Results:A total of 20 case–control studies, 3 cohort studies, and 1 pooled analysis of cohort studies were included in the meta-analysis. We observed that alcoholic beverage intake was associated with a lower risk of renal cell cancer in combined analysis of case–control and cohort studies; for total alcoholic beverage intake, combined RRs (95% confidence intervals) comparing top with bottom categories were 0.76 (0.68–0.85) in case–control studies, and 0.71 (0.63–0.78) in cohort studies (P for difference by study design=0.02). The inverse associations were observed for both men and women and for each specific type alcoholic beverage (beer, wine, and liquor). Also, we found that one drink per day of alcoholic beverage conferred the reduction in renal cell cancer risk, but further drinking above that level did not add benefit.Conclusion:The findings from our meta-analysis support the hypothesis that alcoholic beverage intake is inversely associated with a lower risk of renal cell cancer, with moderate consumption conferring the protection and higher consumption conferring no additional benefits.

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Meta‐analysis of alcohol consumption and risk of extrahepatic bile system cancer

Abstract: There is evidence that moderate alcohol consumption lowers the risk of EBSC compared with non-/low alcohol consumption, but not heavy alcohol consumption. Further multicenter and better controlled studies are required to confirm these findings.

Cited by 9 publications

References 34 publications

Statin use and risk of gallstone disease: A meta‐analysis

Statin use and risk of gallstone disease: A meta‐analysis

Controversial risk factors for cholangiocarcinoma

Alcohol intake and renal cell cancer risk: a meta-analysis

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