Meta-analysis

Xie, Tingting; Cui, Xiaobing; Zheng, Haoxuan; Chen, Dong; He, Ling; Jiang, Bo

doi:10.1097/meg.0b013e328363e2c7

Cited by 38 publications

(24 citation statements)

References 77 publications

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“…They showed that fasting gastric juice pH of H. pylori positive gastric ulcer changes significantly from 6 to 2 after eradication. Reflux esophagitis is well known to occur in approximately 10% of subjects after eradication therapy [31,32], suggesting that significant improvement of gastric acidity should be observed shortly after eradication in cases without histological improvement of atrophy.…”

Section: Discussionmentioning

confidence: 99%

Cutoff Pepsinogen Level for Predicting Unintendedly Eradicated Cases of Helicobacter pylori Infection in Subjects with Seemingly Normal Pepsinogen Levels

Kishikawa¹,

Kimura²,

Ito³

et al. 2017

Digestion

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Backgrounds/Aims: In the ABC method, which is a method for risk stratification of gastric cancer using serum anti-Helicobacter pylori antibody and pepsinogen (PG) test, subjects with normal PG and seronegative for H. pylori are named as “Group A” and are regarded as having a low risk of gastric cancer. These “Group A” subjects include unintentionally eradicated cases at relatively high risk, and this study aimed to identify these subjects. Methods: Of the 109 subjects, 76 were classified as uninfected Group A subjects with negative histologic H. pylori infection and no histologic and endoscopic atrophy, and 33 subjects were classified serologically as Group A after successful eradication, which are serologically equal to the unintendedly eradicated cases in Group A. The usefulness of measuring PG levels to detect post-eradication cases was validated by using a receiver operating characteristic (ROC) curve analysis. Results: The area under the ROC curve for PGI level was 0.736 ± 0.06 (p < 0.01; cutoff value, 37.0 ng/mL; sensitivity, 77.6%; specificity, 72.7%), and that for the PGI/II ratio was 0.660 ± 0.06 (p < 0.01; cutoff value, 5.1; sensitivity, 84.2%; specificity, 43.4%). Conclusion: PGI levels of ≤37 ng/mL and PGI/II ratios of ≤5.1 effectively identified unintendedly eradicated cases in Group A.

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Section: Discussionmentioning

confidence: 99%

Cutoff Pepsinogen Level for Predicting Unintendedly Eradicated Cases of Helicobacter pylori Infection in Subjects with Seemingly Normal Pepsinogen Levels

Kishikawa¹,

Kimura²,

Ito³

et al. 2017

Digestion

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“…However, the relationship between GERD and H. pylori remains incompletely defined ( 29 ). Several studies suggested that eradication of H. pylori infection in the setting of duodenal ulcer disease would result in an increase in GERD symptoms ( 3 , 30 ). In other words, an inverse association of H. pylori infection with decreased rate of this sort of disease was a challenging topic in new gastroenterology ( 14 , 31 – 33 ).…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori: A Beneficial Gastric Pathogen?

Abadi

2014

Front. Med.

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“…Discordant results are also referred to the need of H. pylori eradication in GERD patients. In fact, some evidence suggests that eradication of the infection may be a risk factor for denovo endoscopic esophagitis [16] , whereas other studies report a low risk of gastric atrophy in patients with successful H. pylori eradication and undergoing long-term acid suppression with PPI [17] . Our study tried to look at this relationship from another perspective.…”

Section: Discussionmentioning

confidence: 96%

Typical and atypical symptoms of gastro esophageal reflux disease: DoesHelicobacter pyloriinfection matter?

Grossi

Ciccaglione

Marzio

2015

WJGPT

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AIM:To analyze whether the presence of Helicobacter pylori (H. pylori ) infection could affect the quality of symptoms in gastro-esophageal reflux disease (GERD) patients.METHODS: one hundred and forty-four consecutive patients referred to our Unit for suspected GERD were recruited for the study. All patients underwent esophageal pH-metric recording. For those with a positive test, C13 urea breath test was then performed to assess the H. pylori status. GERD patients were stratified according to the quality of their symptoms and classified as typical, if affected by heartburn and regurgitation, and atypical if complaining of chest pain, respiratory and ears, nose, and throat features. H. pylori -negative patients were also asked whether they had a previous diagnosis of H. pylori infection. If a positive response was given, on the basis of the time period after successful eradication, patients were considered as "eradicated" (E) if H. pylori eradication occurred more than six months earlier or "recently eradicated" if the therapy had been administered within the last six months. Patients without history of infection were identified as "negative" (N CONCLUSION: Atypical symptoms of GERD occur more frequently in H. pylori -positive patients than in H. pylori -negative subjects. In addition, atypical symptoms tend to decrease after H. pylori eradication.

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Meta-analysis

Abstract: H. pylori infection shows a negative association with the development of endoscopic GORD. Eradication of the infection may be a risk factor for de-novo endoscopic GORD, especially in Asian populations.

Cited by 38 publications

References 77 publications

Cutoff Pepsinogen Level for Predicting Unintendedly Eradicated Cases of <b><i>Helicobacter pylori</i></b> Infection in Subjects with Seemingly Normal Pepsinogen Levels

Cutoff Pepsinogen Level for Predicting Unintendedly Eradicated Cases of <b><i>Helicobacter pylori</i></b> Infection in Subjects with Seemingly Normal Pepsinogen Levels

Helicobacter pylori: A Beneficial Gastric Pathogen?

Typical and atypical symptoms of gastro esophageal reflux disease: DoesHelicobacter pyloriinfection matter?

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