Meta-analysis identifies the effect of dietary multi-enzyme supplementation on gut health of pigs

Ramani, Sivasubramanian; Recharla, Neeraja; Hwang, Ok-Hwa; Jeong, Jinyoung; Park, Sungkwon

doi:10.1038/s41598-021-86648-7

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Following exposure to pesticides, the liver and kidneys have been shown to exhibit a change in the vacuoles in the proximal tubules, causing necrosis and hepatocellular damage, respectively ( Eid, 2017 ; Lenz et al, 2018 ). Multi-enzyme may benefit more than single or two enzyme supplement to improving gut health ( Ramani et al, 2021 ). These changes can be observed within our study.…”

Section: Resultsmentioning

confidence: 99%

Effect of Pesticide Residue in Muscle and Fat Tissue of Pigs Treated with Propiconazole

Jeong¹,

Kim²,

Ji³

et al. 2021

Food Sci Anim Resour

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This study estimated the effect of exposure to propiconazole through implementation and residues in finishing pigs. We analyzed the expression of fibrosis-related genes and performed histological analysis of the blood, liver, kidney, muscle, ileum, and fat tissues. The animals were exposed for 28 d to different concentrations of propiconazole (0.09, 0.44, 0.88, 4.41, and 8.82 mg/kg bw/d). Quantitative, gene expression, and histological analyses in tissues were performed using liquid chromatography mass spectrometry, real-time PCR, and Masson's trichrome staining, respectively. Final body weight did not differ among groups. However, genes involved in fibrosis were significantly differentially regulated in response to propiconazole concentrations. Glucose, alanine aminotransferase, and total bilirubin levels were significantly increased compared with those in the control group, while alkaline phosphatase level was decreased (p < 0.05) after exposure to propiconazole. The residue limits of propiconazole were increased in the finishing phase at 4.41 and 8.82 mg/kg bw/d. The liver, kidney, and ileum showed blue staining after propiconazole treatment, confirmed by Masson's trichrome staining. In conclusion, these findings suggest that propiconazole exposure disturbs the expression of fibrosis-related genes.This study on dietary propiconazole in pigs can provide a basis for determining maximum residue limits and a better understanding of metabolism in pigs and meat products.

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Section: Resultsmentioning

confidence: 99%

Effect of Pesticide Residue in Muscle and Fat Tissue of Pigs Treated with Propiconazole

Jeong¹,

Kim²,

Ji³

et al. 2021

Food Sci Anim Resour

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“…Exposure to residual pesticides increased liver fibrosis and nonalcoholic fatty liver disease in HepG2 cells and rat liver ( Kwon et al, 2021a ; Kwon et al, 2021b ). Furthermore, meta-analysis revealed that the risk of idiopathic pulmonary fibrosis increased in agricultural workers exposed to pesticides ( Park et al, 2021 ; Ramani et al, 2021 ). Pesticide residues have a substantial influence on growth and health of livestock and humans ( Abou-donai, 2003 ; Cordes and Foster, 1988 ; Moses, 1989 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Flutriafol Exposure on Residue Characteristics in Pig Muscle and Fat Tissue

Jeong¹,

Kim²,

Ji³

et al. 2022

Food Sci Anim Resour

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This study investigated the effect of exposure to flutriafol based on residues in pigs. Pigs were exposed to different concentrations (0.313, 0.625, 3.125, 6.25, and 12.5 mg/kg bw/d, n=20) for 4 wk in different treatment groups. Serum biochemical analysis, residue levels, and histological analysis were conducted using the VetTest chemistry analyzer, liquid chromatography mass spectrometry, and Masson’s trichrome staining, respectively. The body weight (initial and final) was not significantly different between groups. Parameters such as creatinine, blood urea nitrogen, alanine aminotransferase, and lipase levels were significantly different as compared to the control group. Flutriafol increased the residue limits in individual tissue of the pigs in a dose dependent manner. Flutriafol exposures indicated the presence of fibrosis, as confirmed from Masson’s trichrome staining. These results suggest that flutriafol affects the morphology and serum levels in pigs. The dietary flutriafol levels can provide a basis for maximum residue limits and food safety for pork and related products.

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Influence of protected organic acids on growth performance, fecal microbial composition, gas emission, and apparent total tract digestibility in growing pigs

2022

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This study was conducted to assess the effect of protected organic acids on growth performance, fecal microbial composition, gas emission, and apparent total tract digestibility in growing pigs. A total of 80 crossbred (Landrace × Yorkshire) × Duroc) growing pigs with average initial body weight of 22.66±2.45 kg were allotted to one of two dietary treatments with 8 replications and 5 pigs (3 gilts and 2 barrows) per pen in a randomized complete block design in a 6-week study with CON, Basal diets; MOA, Basal diets + 0.2% microencapsulated organic acids. A trend and significant effect on average daily gain were observed during weeks 2 and 6 (P<0.05), respectively. The gain-feed ratio was increased (P=0.0032) in the MOA group. ADG (P=0.0109) and trend in G: F (P=0.1010) were observed in MOA group. However, no difference was observed on the BW and average daily feed intake of pigs. Fecal E. coli counts showed reduction (P=0.0143) at week 4. Microencapsulated organic acid supplementation had no influence on ATTD and fecal gas emission in growing pigs during the entire experiment (P>0.05). The MOA supplementation to the basal diet had a positive effect on the growth performance and fecal microbial composition of growing pigs.

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Meta-analysis identifies the effect of dietary multi-enzyme supplementation on gut health of pigs

Cited by 3 publications

References 41 publications

Effect of Pesticide Residue in Muscle and Fat Tissue of Pigs Treated with Propiconazole

Effect of Pesticide Residue in Muscle and Fat Tissue of Pigs Treated with Propiconazole

Effect of Flutriafol Exposure on Residue Characteristics in Pig Muscle and Fat Tissue

Influence of protected organic acids on growth performance, fecal microbial composition, gas emission, and apparent total tract digestibility in growing pigs

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