Effect of Flutriafol Exposure on Residue Characteristics in Pig
                    Muscle and Fat Tissue

Jeong, Jin Young; Kim, Byeonghyeon; Ji, Sang Yun; Baek, Youl Chang; Kim, Min Ji; Park, Seol Hwa; Jung, Hyun-Jung

doi:10.5851/kosfa.2021.e61

Cited by 2 publications

(4 citation statements)

References 40 publications

(47 reference statements)

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“…Thus, tebuconazole treatment at different concentrations for 28 d did not affect the growth performance of pigs. These results are similar to those of other previous studies ( Jeong et al, 2021 ; Jeong et al, 2022 ; Lopez-Antia et al, 2021 ). Propiconazole and flutriafol were not significantly different between control and the treatment groups in pigs and chicks.…”

Section: Resultssupporting

confidence: 93%

“…ALT regulates transamination and is a marker for functional damage in the liver and kidney ( Firat et al, 2011 ; Ochiai et al, 2020 ; Sookoian and Pirola, 2012 ). Previous studies have also shown that triazole fungicides (i.e., propiconazole and flutriafol) increased the ALT levels in pigs ( Jeong et al, 2021 ; Jeong et al, 2022 ). ALT levels increase ROS levels and oxidative damage ( Patil et al, 2009 ; Singh et al, 2011 ).…”

Section: Resultsmentioning

confidence: 87%

“…Our previous studies based on equation models suggested that triazole fungicides (propiconazole and flutriafol) showed different residual levels ( Jeong et al, 2021 ; Jeong et al, 2022 ). In this study, despite acute exposures at high concentrations, the reason for no residual amount in blood, kidney, and muscle tissue is assumed to be the residual characteristics depending on individual tissues because they are excreted.…”

Section: Resultsmentioning

confidence: 99%

“…Pesticide residues are harmful to the growth and health of animals and plants ( Chandra et al, 2021 ; Damalas and Eleftherohorinos, 2011 ). Chronic pesticide exposure can cause fibrosis in human and animal tissues ( Jeong et al, 2021 ; Jeong et al, 2022 ; Park et al, 2021 ), thereby impairing the functioning of their organs. We assumed that tebuconazole fungicides can cause fibrosis in pigs.…”

Section: Introductionmentioning

confidence: 99%

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Residual Level, Histology, and Blood Biochemistry of Tebuconazole: A Repeated Dose 28-Day Oral Toxicity Study in Pigs

Jeong¹,

Kim²,

Park³

et al. 2022

Food Sci Anim Resour

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In this study, we investigated the residual properties of tebuconazole-treated pigs. Twentypigs were treated with different concentrations (0.25, 1.25, 2.5, 12.5, and 25 mg/kg bw/d) of tebuconazole for 28 d. Blood biochemistry, histology, and residual levels were analyzed using the VetTest analyzer, Masson’s trichrome staining kit, and liquid chromatography-mass spectrometry, respectively. The final body weights were not significantly different between the control and treatment groups. Alkaline phosphatase, blood urea nitrogen, cholesterol, and gamma-glutamyl transpeptidase levels were significantly different from those of the control after exposure for 14 d. However, alanine aminotransferase levels showed changes only after exposure to pesticides for 28 d. The biochemical parameters were separated during the experimental period (14 d versus 28 d) by principal component analysis. Based on variable importance plots, blood urea nitrogen/creatinine ratio, blood urea nitrogen, glucose, and gamma-glutamyl transpeptidase are candidate biomarkers for tebuconazole exposure. The residual levels were observed at T4 (12.5 mg/kg bw/d) and T5 (25 mg/kg bw/d) in the liver and fat tissues, respectively. Fibrosis increased in the liver, kidney, and fat tissues, depending on the tebuconazole concentration. In conclusion, the residue limits of tebuconazole and the physiological changes caused by dietary tebuconazole in pigs provide important information for establishing maximum residue limits of pork and pork products.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Residual Level, Histology, and Blood Biochemistry of Tebuconazole: A Repeated Dose 28-Day Oral Toxicity Study in Pigs

Jeong¹,

Kim²,

Park³

et al. 2022

Food Sci Anim Resour

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Study on the current research trends and future agenda in animal products: an Asian perspective

Lee,

Mariano

et al. 2023

J Anim Sci Technol

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This study aimed to analyze the leading research materials and research trends related to livestock food in Asia in recent years and propose future research agendas to ultimately contribute to the development of related livestock species. On analyzing more than 200 relevant articles, a high frequency of studies on livestock species and products with large breeding scales and vast markets was observed. Asia possesses the largest pig population and most extensive pork market, followed by that of beef, chicken, and milk; moreover, blood and egg markets have also been studied. Regarding research keywords, “meat quality” and “probiotics” were the most common, followed by “antioxidants”, which have been extensively studied in the past, and “cultured meat”, which has recently gained traction. The future research agenda for meat products is expected to be dominated by alternative livestock products, such as cultured and plant-derived meats; improved meat product functionality and safety; the environmental impacts of livestock farming; and animal welfare research. The future research agenda for dairy products is anticipated to include animal welfare, dairy production, probiotic-based development of high-quality functional dairy products, the development of alternative dairy products, and the advancement of lactose-free or personalized dairy products. However, determining the extent to which the various research articles’ findings have been applied in real-world industry proved challenging, and research related to animal food laws and policies and consumer surveys was lacking. In addition, studies on alternatives for sustainable livestock development could not be identified. Therefore, future research may augment industrial application, and multidisciplinary research related to animal food laws and policies as well as eco-friendly livestock production should be strengthened.

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Effect of Flutriafol Exposure on Residue Characteristics in Pig Muscle and Fat Tissue

Cited by 2 publications

References 40 publications

Residual Level, Histology, and Blood Biochemistry of Tebuconazole: A Repeated Dose 28-Day Oral Toxicity Study in Pigs

Residual Level, Histology, and Blood Biochemistry of Tebuconazole: A Repeated Dose 28-Day Oral Toxicity Study in Pigs

Study on the current research trends and future agenda in animal products: an Asian perspective

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