Meta‐analysis: Association of <i>Helicobacter pylori</i> infection with Parkinson's diseases

Shen, Xiaoli; Yang, Huazhen; Wu, Yili; Zhang, Dongfeng; Jiang, Hong

doi:10.1111/hel.12398

Cited by 82 publications

(73 citation statements)

References 51 publications

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“…HP infection has been found to increase the synthesis of MPTP or MPTP‐like substance (Altschuler, ) and cause chronic inflammation in central nervous system which damage dopaminergic neurons (Hirai et al, ) via activating microglia (Streit, Mrak, & Griffin, ), releasing neurotoxic substances (Villarán et al, ), or inducing autoimmune responses (Dobbs et al, ). HP infection may also affect symptoms of PD via decreasing absorption of levodopa and was related to poorer motor function in PD patients (Shen et al, ; Suwarnalata et al, ). Therefore, HP infection may be a potential causal factor of PD onset.…”

Section: Discussionmentioning

confidence: 99%

“…Infection of various pathogenic microorganisms has been thought associated with increased risk of PD, including Helicobacter pylori (HP; Shen, Yang, Wu, Zhang, & Jiang, 2017), hepatitis C virus (HCV; Wijarnpreecha, Chesdachai, Jaruvongvanich, & Ungprasert, 2018), Malassezia (Laurence, Benito-León, & Calon, 2019), Chlamydophila pneumoniae (C. pneumonia; Bu et al, 2015), hepatitis B virus (HBV; Wijarnpreecha et al, 2018), influenza virus (Vlajinac et al, 2013), measles (Vlajinac et al, 2013), varicella-zoster virus (VZV; Hemling et al, 2003), mumps (Vlajinac et al, 2013), German measles (Vlajinac et al, 2013), pertussis (Vlajinac et al, 2013), scarlet fever (Vlajinac et al, 2013), rheumatic fever (Vlajinac et al, 2013), diphtheria (Vlajinac et al, 2013), cytomegalovirus (CMV; Bu et al, 2015), Epstein-Barr virus (EBV; Bu et al, 2015), herpes virus (HSV; Hemling et al, 2003), and Borrelia burgdorferi (B. burgdorferi; Bu et al, 2015). However, there are also studies indicated that infection of these pathogenic microorganisms may decrease or does not affect the risk of PD (Harris, Tsui, Marion, Shen, & Teschke, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Bacterial, viral, and fungal infection‐related risk of Parkinson's disease: Meta‐analysis of cohort and case–control studies

Wang

Tan

et al. 2020

Brain and Behavior

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Aims Recent studies showed that patients with various bacterial, viral, and fungal infections might be at increased risk of Parkinson's disease (PD). However, the risk of PD in patients with each specific infection varied. This meta‐analysis estimated the association between various infections and PD risk. Methods Literature published from January 1965 to October 2019 in PubMed and EMBASE databases was searched. Data were extracted and pooled using random/fixed effects model. Sensitivity analysis and meta‐regression were also performed to analyze the source of heterogeneity. Publication bias was estimated by the trim and fill. Results Twenty‐three out of 6,609 studies were included. Helicobacter pylori (HP; pooled OR = 1.653, 1.426–1.915, p < .001), hepatitis C virus (HCV; pooled OR = 1.195, 1.012–1.410, p = .035), Malassezia (pooled OR = 1.694, 1.367–2.100, p < .001), and pneumoniae (pooled OR = 1.595, 1.020–2.493, p = .041) infection were associated with increased PD risk. Influenza virus, herpes virus, hepatitis B virus, scarlet fever, mumps virus, chicken pox, pertussis, German measles, and measles were not associated with PD risk. After antiviral treatment against HCV reduced the risk of PD in patients with HCV infection (OR = 0.672, 0.571–0.791, p < .001). Significant heterogeneity exists among the included studies. Conclusion Patients with infection of HP, HCV, Malassezia, pneumoniae might be an increased risk of PD. Antiviral treatment of HCV could reduce the risk of PD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bacterial, viral, and fungal infection‐related risk of Parkinson's disease: Meta‐analysis of cohort and case–control studies

Wang

Tan

et al. 2020

Brain and Behavior

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“…One meta-analysis published in 2017 reported an OR of 1.59 for patients with PD and HP. Subgroup analysis revealed a higher OR in Asia than in Europe (1.99 and 1.55, respectively) (22). In another meta-analysis, HP infection was identified as a risk factor in terms of PD, and a decrease in UPDRS scores, indicating severity of PD, was achieved with HP eradication (23).…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori infection is an avoidable risk factor for Parkinson s disease

Çalık¹,

Görgün²,

Yılmaz³

et al. 2019

tjgeri

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HELICOBACTER PYLORI INFECTION IS AN AVOIDABLE RISK FACTOR FOR PARKINSON'S DISEASE Introduction: : Gram-negative bacteria such as Helicobacter pylori (HP) are becoming increasingly implicated in the etiology of Parkinson's disease (PD). This study aimed to investigate the association between PD and HP infections. Materials and Method: Eighty-three patients with PD and age-and sex-matched healthy control subjects with no history of PD were enrolled. Patients with secondary Parkinsonism and severe cognitive impairment were excluded. All patients were staged according to the Hoehn and Yahr scale. We obtained 10 mL venous blood samples from all patients and controls. The plasma was separated, and samples were stored at −200°C. IgG antibodies developing against HP were investigated using the ELISA method. Values >5 IU/ml were considered positive. Results: Eighty-three patients and 81 controls were included in the study. HP IgG was positive in 87% of the patient group and in 74% of the control group. The median antibody titer in the patient group was higher than that in the control group (p=0.0019). No significant relation was observed between disease severity and IgG positivity (p=0.947). However, a moderate correlation was observed between disease severity and mean IgG level (r=0.277, p=0.011). HP IgG positivity (OR 3.15, 95% CI 1.23-8.07, p=0.002), a family history of PD (OR 2.57, 95% CI 1.02-4.13, p= 0.03), and male gender (OR 2.05, 95% CI 0.95-6.99, p= 0.02) increase the likelihood of PD. Conclusion: HP infections may trigger various abnormal or enhanced immunological processes in patients diagnosed with PD; these abnormal immunological activities are probably involved in the disease pathogenesis.

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“…Патогенетическую взаимосвязь болезни Паркинсона с H. pylori ряд авторов [78][79][80] объясняют нарушением проницаемости гематоэнцефалического барьера, нейровоспалением и апоптозом нейроцитов, опосредованными медиаторами хронического воспаления. Не исключены аутоиммунные реакции, обусловленные молекулярной мимикрией бактерии, а также непосредственное проникновение микроорганизма в ткани ЦНС.…”

Section: заболевания нервной системыunclassified

Helicobacter pylori and extragastroduodenal diseases: the proven facts and assumptions

Маев¹,

Бакулин²,

Курилович³

et al. 2018

Dok. gastroenterol.

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В обзоре освещены современные данные об ассоциации инфекции Helicobacter pylori с экстрагастродуоденальными заболеваниями. Проанализирована как негативная, так и защитная роль Н. pylori при заболеваниях крови, центральной нервной системы, органов сердечно-сосудистой и дыхательной систем, метаболических нарушениях, болезнях кишечника и кожи. Рассмотрен потенциальный эффект антихеликобактерной терапии при данной патологии.

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Meta‐analysis: Association of Helicobacter pylori infection with Parkinson's diseases

Abstract: This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.

Cited by 82 publications

References 51 publications

Bacterial, viral, and fungal infection‐related risk of Parkinson's disease: Meta‐analysis of cohort and case–control studies

Bacterial, viral, and fungal infection‐related risk of Parkinson's disease: Meta‐analysis of cohort and case–control studies

Helicobacter pylori infection is an avoidable risk factor for Parkinson s disease

Helicobacter pylori and extragastroduodenal diseases: the proven facts and assumptions

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