[Met]- and [Leu]enkephalin-like immunoreactive cell bodies and nerve fibres in the coeliac ganglion of the cat

Julé, Y; Clerc, Nadine; Niel, Jean-Pierre; Condamin, Madeleine

doi:10.1016/0306-4522(86)90169-7

Cited by 28 publications

(4 citation statements)

References 35 publications

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“…of other species such as cats (Julé et al 1986;Balayadi et al 1988;Bagnol et al 1993) and bovines (Fried et al 1986), the possibility that the enkephalinergic innervation of the pig digestive tract may be also partly of extrinsic origin cannot be ruled out.…”

Section: Discussionmentioning

confidence: 99%

“…Their effects on intestinal motility are mediated by the activation of intrinsic neural opioid pathways (particularly enkephalinergic ones), which may modulate the release of either excitatory neurotransmitters, such as acetylcholine and substance P (Bartho et al 1982;Gintzler and Scalisi 1982;Nakayama et al 1985;Johnson et al 1988), or inhibitory neurotransmitters, such as norepinephrine (Bouvier et al 1986;Julé et al 1986;Balayadi et al 1988), VIP, and NO (Grider and Makhlouf 1987a,b;FoxThrelkeld et al 1994). Opioids activate the absorption of water and electrolytes but block the secretory processes in the small intestine and colon in several species, including pigs and humans (see Kromer 1988).…”

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confidence: 99%

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A Qualitative and Quantitative Study on the Enkephalinergic Innervation of the Pig Gastrointestinal Tract

Porcher

Julé

Henry

2000

J Histochem Cytochem.

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S U M M A R YEnkephalins are involved in neural control of digestive functions such as motility, secretion, and absorption. To better understand their role in pigs, we analyzed the qualitative and quantitative distribution of enkephalin immunoreactivity (ENK-IR) in components of the intestinal wall from the esophagus to the anal sphincter. Immunohistochemical labelings were analyzed using conventional fluorescence and confocal microscopy. ENK-IR was compared with the synaptophysin immunoreactivity (SYN-IR). The results show that maximal ENK-IR levels in the entire digestive tract are reached in the myenteric plexuses and, to a lesser extent, in the external submucous plexus and the circular muscle layer. In the longitudinal muscle layer, ENK-IR was present in the esophagus, stomach, rectum, and anal sphincter, whereas it was absent from the duodenum to the distal colon. In the ENK-IR plexuses and muscle layers, more than 60% of the nerve fibers identified by SYN-IR expressed ENK-IR. No ENK-IR was observed in the internal submucous plexus and the mucosa; the latter was found to contain ENK-IR endocrine cells. These results strongly suggest that, in pigs, enkephalins play a major role in the regulatory mechanisms that underlie the neural control of digestive motility.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

A Qualitative and Quantitative Study on the Enkephalinergic Innervation of the Pig Gastrointestinal Tract

Porcher

Julé

Henry

2000

J Histochem Cytochem.

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“…The data also suggest that the parasympathetic innervation of the liver may play an important regulatory role in liver regeneration 4 . In addition to catecholamine and acetylcholine, these nerve fibers can also release other neurotransmitters, calcitonin gene‐related peptide, 9 somatostatin, 10 vasoactive intestinal peptide, neuropeptide Y, 11,12 enkephalin 13 and bombesin 14 …”

Section: Bile Acids and Nervous System In The Livermentioning

confidence: 96%

Novel interaction of bile acid and neural signaling in the regulation of cholangiocyte function

Fava

Marzioni

Francis

et al. 2007

Hepatology Research

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Cholangiocytes, the epithelial cells that line the intrahepatic biliary tree, are the target of cholangiopathies, a wide array of chronic disorders that are characterized by the progressive vanishing of bile ducts, leading to ductopenia and liver failure. The loss of bile ducts is a consequence of cholangiocyte death by apoptosis and impaired proliferative response of these cells to injury. The factors that regulate cholangiocyte proliferation and survival are poorly understood. In this regard, a major role is played by the interaction between bile acids and the autonomic nervous system. It has been shown that adrenergic and cholinergic denervation of the liver results in the induction of cell death and impaired proliferative responses of the biliary epithelium to cholestasis. In addition,bile acids have been shown to enter cholangiocytes through the apical, Na(+)-dependent bile acid transporter, ASBT, which has a marked impact on cholangiocyte pathobiology. Recent evidence shows that bile acids and autonomic innervation interact in modulating cholangiocyte response to liver injury. In this review, we describe the recent advances in understanding the molecular mechanisms by which such events occur.

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“…Galanin (GAL) is expressed in the pig IMG (Pidsudko et al, 2001), while neuronal nitric oxide synthase (nNOS) is expressed in the mouse CG and SMG (Kaestner et al, 2019), in the cat CG (Emanuilov et al, 2008; Masliukov et al, 2015), and in the guinea pig (Parr & Sharkey, 1996) and pig IMGs (Pidsudko et al, 2001). Calcitonin gene‐related peptide is expressed in the cat CG (Masliukov et al, 2015) and pig IMG (Majewski & Heym, 1992), while enkephalin (ENK) is expressed in the cat CG (Julé et al, 1986) and IMG (Balayadi et al, 1988).…”

Section: Anatomy Of the Sympathetic Innervation Of The Gastrointestin...mentioning

confidence: 99%

Sympathetic innervation of the development, maturity, and aging of the gastrointestinal tract

Maslyukov

Emanuilov

Budnik

2022

The Anatomical Record

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The sympathetic nervous system inhibits gut motility, secretion, and blood flow in the gut microvasculature and can modulate gastrointestinal inflammation. Sympathetic neurons signal via catecholamines, neuropeptides, and gas mediators. In the current review, we summarize the current understanding of the mature sympathetic innervation of the gastrointestinal tract with a focus mainly on the prevertebral sympathetic ganglia as the main output to the gut. We also highlight recent work regarding the developmental processes of sympathetic innervation. The anatomy, neurochemistry, and connections of the sympathetic prevertebral ganglia with different parts of the gut are considered in adult organisms during prenatal and postnatal development and aging. The processes and mechanisms that control the development of sympathetic neurons, including their migratory pathways, neuronal differentiation, and aging, are reviewed.

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[Met]- and [Leu]enkephalin-like immunoreactive cell bodies and nerve fibres in the coeliac ganglion of the cat

Cited by 28 publications

References 35 publications

A Qualitative and Quantitative Study on the Enkephalinergic Innervation of the Pig Gastrointestinal Tract

A Qualitative and Quantitative Study on the Enkephalinergic Innervation of the Pig Gastrointestinal Tract

Novel interaction of bile acid and neural signaling in the regulation of cholangiocyte function

Sympathetic innervation of the development, maturity, and aging of the gastrointestinal tract

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