Mesoscopic simulations of drug-loaded diselenide crosslinked micelles: Stability, drug loading and release properties

Lin, Wenjing; Xue, Zhaolin; Wen, Liyang; Li, Yanzhe; Liang, Zhaohui; Xu, Jianchang; Yang, Chufen; Gu, Yuxin; Zhang, Jie; Zu, Xihong; Luo, Hongsheng; Yi, Guobin; Zhang, Lijuan

doi:10.1016/j.colsurfb.2019.06.043

Cited by 22 publications

(12 citation statements)

References 41 publications

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“…Under neutral condition, PDEAEMA segment was relatively hydrophobic leading to the compact polymeric micelles. Under the acidic condition, however, the pendant tertiary amine groups in PDEAEMA were protonated and become to be hydrophilic, leading to the loose and turgid polymeric micelles [ 38 ]. Moreover, the pH-responsive function of polymeric micelles was further supported by TEM observation.…”

Section: Resultsmentioning

confidence: 99%

“…The desired drug-loading capacity of polymeric micelles might be attributed to the bulky and rigid adamantane core as well as hydrophobic PLGA and PDEAEMA segments, which were advantageous to entrap more drugs. In our previous works [ 10 , 23 , 38 ], it was manifested that the length of hydrophobic segments played an important role in drug loading capacity of drug-loaded micelles, for instance, longer hydrophobic segments resulted in higher LCs values. Interestingly, with the nearly identical blocks ratio of polymer for one arm, the LCs of DOX@S-PLGA-D-P and DOX@L-PLGA-D-P were 22.9% and 21.6%, respectively, which demonstrated that the topological structure of star-shaped and linear polymers did not seem to be a key factor for drug loading capacity of the DOX-loaded micelles.…”

Section: Resultsmentioning

confidence: 99%

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Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Wen

Guo

2021

Nanomaterials

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Four-arm star-shaped (denoted as ‘S’) polymer adamantane-[poly(lactic-co-glycolic acid)-b-poly(N,N’-diethylaminoethyl methacrylate) poly(ethylene glycol) monomethyl ether]4 (S-PLGA-D-P) and its linear (denoted as ‘L’) counterpart (L-PLGA-D-P) were synthesized, then their self-assembled micelles were further developed to be platforms for anticancer drug delivery. Two types of polymeric micelles exhibited strong pH-responsiveness and good drug loading capacity (21.6% for S-PLGA-D-P and 22.9% for L-PLGA-D-P). Using doxorubicin (DOX) as the model drug, their DOX-loaded micelles displayed well controlled drug release behavior (18.5–19.0% of DOX release at pH 7.4 and 77.6–78.8% of DOX release at pH 5.0 within 80 h), good cytocompatibility against NIH-3T3 cells and effective anticancer efficacy against MCF-7 cells. However, the star-shaped polymeric micelles exhibited preferable stability, which was confirmed by the lower critical micelle concentration (CMC 0.0034 mg/mL) and decrease rate of particle sizes after 7 days incubation (3.5%), compared with the linear polymeric micelle L-PLGA-D-P (CMC 0.0070 mg/mL, decrease rate of particle sizes was 9.6%). Overall, these developed polymeric micelles have promising application as drug delivery system in cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Wen

Guo

2021

Nanomaterials

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“…Typically, they include viruses, liposomes, and micelles. (Figure 2(C4)) They penetrate the cells easier than other nanocarriers due to their unique characteristics, such as having a specific ligand at the cellular level 178 . Many improvements have been made on nanoparticles.…”

Section: Application Of Nanoparticles In Ddssmentioning

confidence: 99%

Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems

Ghaderpour

Hoseinkhani

Yarani

et al. 2021

Polymers for Advanced Techs

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Nowadays, nanofibers have various applications in the field of medical biology including drug delivery systems (DDSs) and tissue engineering. Many methods have been developed to produce drug release polymers; the most important and applicable of which is known as electrospinning. In this method, the nanoscale and microscale fibers are used as the functional polymers in the DDSs. A variety of electrospinning methods can be used for delivery systems and tissue engineering. The nanofibers loaded with anticancer drugs have attracted a lot of attention in the last decade. Electrospun parameters include voltage, feed rate, rotary collector, pipette or needle hole diameter, the distance between nozzle tip to collector plate, viscosity and molecular weight of the polymer, surface tension, solubility of polymer, soluble electrical conductivity, dielectric constant, and evaporability of the solution; all could be manipulated to regulate the drug release rate in order via changing the diameter of the nanofibers. In addition to directly loading the drug on nanofibers, the nanoparticles are also used to improve the drug efficacy and reduce the required dose, especially in the case of harmful drugs. Depending on the need, various nanoparticles and nanocarriers are being applied along with the drug. Nanocarriers such as viruses, micelles, and liposomes function highly specific since they carry specific ligands on their surface. Magnetic nanoparticles also have a great therapeutic effect on cancer cells when exposed to heat and magnetic fields. Carbon nanoparticles, such as graphene and graphene oxide, due to their layering, can pass through the cell membrane and deliver the drug to the intracellular space.

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“…Subsequently, DPD simulation and Materials Studio (MS) script, based on the nearest-neighbor bonding principle, were used to explore the formation process of [PCL-(PHEMA-SeSe$)-PPEGMA] 6 crosslinked micelles. 38,39 Finally, we used DPD simulations and another MS script to study the growth process of GNPs. [PCL-(PHEMA-SeSe$)-PPEGMA] 6 was synthesized by the ROP of ε-CL and continuous ARGET ATRP of HEMA and PEGMA, following by the Michael addition reaction, as illustrated in Figure 1.…”

Section: Computer Simulationmentioning

confidence: 99%

Diselenide‐bearing crosslinked micelles‐reduced and stabilized gold nanoparticles in‐situ

Lin

Yan

Pan

et al. 2021

J of Applied Polymer Sci

Self Cite

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Gold nanoparticles (GNPs), usually fabricated through reduction and stabilization two steps, have been widely used in biomedical field. Here, the six-armed star copolymer was synthesized and self-assembled into crosslinked micelles for the in-situ preparation of GNPs in one-step without external reductant.The copolymer and their precursors were synthesized by a combination of ring-opening polymerization (ROP), activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP), and Michael addition reaction. Their molecular weights and structures were measured by gel permeation chromatography (GPC) and 1 H NMR. The diselenide bond of crosslinked micelles reduced AuCl 4 À to GNPs, and the crosslinked micelles stabilized the GNPs in-situ. Through increasing AuCl 4 À concentration, the collision probability between the GNPs increased, with particle diameters of 1.5, 2.3, and 3.0 nm. Moreover, the GNPs showed good stability, and the wavelength of maximum absorbance (λ max ) did not change under different dilution, temperature, and storage conditions. Furthermore, integrating dissipative particle dynamics (DPD) simulations and scripts with experiments, the formation process of crosslinked micelles, the stabilization process, and the size regulation of GNPs at mesoscopic scale were revealed. Therefore, this stable crosslinked micelles/GNPs hybrid material is expected to be used as a nanocarrier in an integrated diagnosis and treatment system.

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Mesoscopic simulations of drug-loaded diselenide crosslinked micelles: Stability, drug loading and release properties

Cited by 22 publications

References 41 publications

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems

Diselenide‐bearing crosslinked micelles‐reduced and stabilized gold nanoparticles in‐situ

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