Mesoporous silicon nanoparticles loaded with salinomycin for cancer therapy applications

Konoplyannikov, Mikhail; Eremina, Anna S.; Kargina, Yu. V.; Le-Deygen, Irina M.; Kharin, Alexander; Bazylenko, T. Yu.; Yusubalieva, Gaukhar M.; Revkova, V. A.; Matchuk, Olga N.; Замулаева, И. А.; Abramova, M.R.; Kotova, Svetlana; Timashev, Peter; Baklaushev, Vladimir P.; Timoshenko, V. Yu.

doi:10.1016/j.micromeso.2021.111473

Cited by 9 publications

(5 citation statements)

References 19 publications

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“…We showed earlier that the salinomycin solution concentration most efficient against tumor cells is 10–20 µM [ 40 ]. In this study, we used the concentration of 10 µM to test the hypothesis about the efficacy of a combined action of salinomycin and THz radiation.…”

Section: Resultsmentioning

confidence: 99%

“…We showed earlier that salinomycin-based preparations (salinomycin-loaded mesoporous silicon nanoparticles) demonstrated a notable cytotoxic effect on human glioblastoma cells, and MCF-7 and MCF-7/MDR1 breast cancer cells. The experiments in vivo demonstrated that the growth of Lewis lung carcinoma was essentially suppressed after intraperitoneal administration of the salinomycin-loaded nanocomposite [ 40 ]. Those results are in good agreement with the data on salinomycin treatment of melanoma in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

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Sensitivity of Neuroblastoma and Induced Neural Progenitor Cells to High-Intensity THz Radiation

Ситников

Revkova

Ilina

et al. 2023

IJMS

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THz radiation induces a variety of processes in cells and has attracted the attention of researchers in recent decades. Here, data on the effects of high-intensity terahertz (THz) radiation on human directly reprogrammed neural progenitor cells (drNPCs) and on neuroblastoma cells (SK-N-BE (2)) were obtained for the first time. The results demonstrated that the exposure of non-tumor and tumor cells to broadband (0.1–3 THz) THz pulses with the intensity of 21 GW/cm2 and the electric field strength of 2.8 MV/cm for 30 min induced neither a noticeable genotoxic effect nor a statistically significant change in the proliferative activity and cell differentiation. It was also shown that the combined effect of THz radiation and salinomycin, a promising antitumor agent, on neuroblastoma cells did not enhance the genotoxic effect of this antibiotic. However, further studies involving chemotherapy drugs and other exposure parameters are warranted to introduce this new concept into anti-tumor clinical practice and to enhance the efficacy of the existing approaches.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sensitivity of Neuroblastoma and Induced Neural Progenitor Cells to High-Intensity THz Radiation

Ситников

Revkova

Ilina

et al. 2023

IJMS

Self Cite

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“…One could see large agglomerates in TEM images of m-PSi NPs dried on a substrate, however, in aqueous suspensions, water stands as a surfactant preventing strong agglomeration and providing their short-term colloidal stability [ 33 ] (see image of a suspension in Figure S1 of Supplementary Materials ). Our detailed studies of the size distribution of m-PSi NPs by a scanning electron microscope (SEM) followed with an analysis of the obtained SEM images by using neural network algorithms [ 38 ] and by atomic force microscopy [ 39 ] revealed an average size of the NPs of 80 ± 25 nm. Note, there is a significant fraction of NPs with sizes varying from 50 to 100 nm, which, according to the previous studies, can easily interact with cell membrane via the electrostatic interaction [ 40 ] and endocytosis [ 41 , 42 ] mechanisms.…”

Section: Resultsmentioning

confidence: 99%

“…Our previous studies of similar m-PSi NPs by using a method of the isotherms of adsorption and desorption of molecular nitrogen reveled pore sizes distributed mainly from 2 to 10 nm [ 38 ]. Such pore sizes are typical for mesoporous materials [ 46 ] and are beneficial for drug loading [ 15 , 17 , 39 ], as well as for the preservation of air bubbles standing as nucleation centers of acoustic cavitation [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Effect of Acoustic Cavitation Promoted by Mesoporous Silicon Nanoparticles

Sviridov

Mazina

Ostapenko

et al. 2023

IJMS

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As-prepared mesoporous silicon nanoparticles, which were synthesized by electrochemical etching of crystalline silicon wafers followed by high-energy milling in water, were explored as a sonosensitizer in aqueous media under irradiation with low-intensity ultrasound at 0.88 MHz. Due to the mixed oxide-hydride coating of the nanoparticles’ surfaces, they showed both acceptable colloidal stability and sonosensitization of the acoustic cavitation. The latter was directly measured and quantified as a cavitation energy index, i.e., time integral of the magnitude of ultrasound subharmonics. The index turned out to be several times greater for nanoparticle suspensions as compared to pure water, and it depended nonmonotonically on nanoparticle concentration. In vitro tests with Lactobacillus casei revealed a dramatic drop of the bacterial viability and damage of the cells after ultrasonic irradiation with intensity of about 1 W/cm2 in the presence of nanoparticles, which themselves are almost non-toxic at the studied concentrations of about 1 mg/mL. The experimental results prove that nanoparticle-sensitized cavitation bubbles nearby bacteria can cause bacterial lysis and death. The sonosensitizing properties of freshly prepared mesoporous silicon nanoparticles are beneficial for their application in mild antibacterial therapy and treatment of liquid media.

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“…), что, в свою очередь, позволяет повышать стабильность, время циркулирования в кровеносной системе, контролировать цитотоксичность и время выхода лекарств под действием внешних воздействий [95,96]. В настоящее время методы изготовления наночастиц пористого кремния продолжают активно развиваться для упрощения, удешевления и масштабирования процедуры их получения, а также для того, чтобы придать им новые функциональные свойства [93,94,96].…”

Section: твёрдые липидные наночастицыunclassified

Nanoencapsulated Systems: Promising Biomedical Initiatives in Pharmacology

Genatullina,

Yasenyavskaya,

Tsibizova

et al. 2024

A&Ch

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The most important direction of modern pharmacology is the study of systems used for controlled and targeted delivery of medications, which is carried out by creating nanoencapsulated forms of different nature and chemical structure. Nanoencapsulation is a promising method for creating innovative dosage forms with prolonged action, which allows expanding the range of medications, as well as changing approaches to various diseases that require long-term therapy. This review provides information highlighting the most promising classes of nanosized drug carriers, describes the processes of their use based on lipids, polymers, and biodegradable mineral substances, as well as provides examples of their use in modern pharmaceutical practice.

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Mesoporous silicon nanoparticles loaded with salinomycin for cancer therapy applications

Cited by 9 publications

References 19 publications

Sensitivity of Neuroblastoma and Induced Neural Progenitor Cells to High-Intensity THz Radiation

Sensitivity of Neuroblastoma and Induced Neural Progenitor Cells to High-Intensity THz Radiation

Antibacterial Effect of Acoustic Cavitation Promoted by Mesoporous Silicon Nanoparticles

Nanoencapsulated Systems: Promising Biomedical Initiatives in Pharmacology

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