Mesoporous silica sub-micron spheres as drug dissolution enhancers: Influence of drug and matrix chemistry on functionality and stability

Brigo, Laura; Scomparin, Elisa; Galuppo, Marco; Capurso, Giovanni; Ferlin, María Grazia; Bello, Valentina; Realdon, Nicola; Brusatin, Giovanna; Morpurgo, Margherita

doi:10.1016/j.msec.2015.10.039

Cited by 8 publications

(3 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 shows the TEM images and EDS elemental analysis result of the agar/5 wt.% silica aerogel nanocomposite film. The TEM images revealed that the film showed a mesoporous microstructure that is typically observed in silica aerogels [15]. As is evident from Fig.…”

Section: Resultssupporting

confidence: 55%

Archives of Metallurgy and Materials

Lee,

Jung,

Lee

et al. 2019

View full text Add to dashboard Cite

In this study, agar-based nanocomposite films containing ultra-porous silica aerogel particles were fabricated by gel casting using an aqueous agar/silica aerogel slurry. The silica aerogel particles did not show significant agglomeration and were homogeneously distributed in the agar matrix. Transmission electron microscopy observations demonstrated that the silica aerogel particles had a mesoporous microstructure and their pores were not incorporated into the agar polymer molecules. The thermal conductivities of the agar and agar/5 wt.% silica aerogel nanocomposite films were 0.36 and 0.20 W• m -1 • K -1 , respectively. The transmittance of the agar films did not decrease upon the addition of silica aerogel particles into them. This can be attributed to the anti-reflection effect of silica aerogel particles.

show abstract

Section: Resultssupporting

confidence: 55%

Archives of Metallurgy and Materials

Lee,

Jung,

Lee

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Empirical knowledge on adsorption phenomena in nanomaterials has been continuously progressing for more than one century. 1 Today, their importance in the chemical industry is considerable, owing to the large number of upmost challenging applications that range from nanofiltration and water desalination, 2-4 health [5][6][7] and food science, 8 and CO 2 storage 9 to shale gas extraction. 10 The understanding of the actual adsorption mechanisms is still however hampered by the increasing complexity of the adsorbed multicomponent systems relevant for these applications.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamics of binary gas adsorption in nanopores

Dutta

Lefort

Morineau

et al. 2016

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

MCM-41 nanoporous silicas show a very high selectivity for monoalcohols over aprotic molecules during adsorption of a binary mixture in the gas phase. We present here an original use of gravimetric vapour sorption isotherms to characterize the role played by the alcohol hydrogen-bonding network in the adsorption process. Beyond simple selectivity, vapour sorption isotherms measured for various compositions help to completely unravel at the molecular level the step by step adsorption mechanism of the binary system in the nanoporous solid, from the first monolayers to the complete liquid condensation.

show abstract

“…Ibuprofen, ((RS)-2-(4-(2-methylpropyl) phenyl) propanoic acid), is a non-steroidal anti-inflammatory drug (NSAID), with recognised low oral bioavailability attributed to its insolubility in water (0.12 mg/ml R-(-)-enantiomer; 0.08 mg/ml S-(+)-enantiomer) Nerurkar et al, 2005. It is an acidic compound (p K a = 4.49), showing therefore higher solubility in neutral-basic environment (Brigo et al, 2016), and in a set of organic solvents e.g. ethanol (0.20 mg/ml) Rashid et al, 2014, chloroform (618 mg/ml) n -octanol (394 mg/ml) and cyclohexane (193 mg/ml) Garzón and Martínez, 2004.…”

Section: Introductionmentioning

confidence: 99%

Ibuprofen nanocrystals developed by 22 factorial design experiment: A new approach for poorly water-soluble drugs

Fernandes

Ferreira²,

Fangueiro

et al. 2017

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

The reduction of the particle size of drugs of pharmaceutical interest down to the nano-sized range has dramatically changed their physicochemical properties. The greatest disadvantage of nanocrystals is their inherent instability, due to the risk of crystal growth. Thus, the selection of an appropriate stabilizer is crucial to obtain long-term physicochemically stable nanocrystals. High pressure homogenization has enormous advantages, including the possibility of scaling up, lack of organic solvents and the production of small particles diameter with low polydispersity index. The sequential use of high shear homogenization followed by high pressure homogenization, can modulate nanoparticles' size for different administration routes. The present study focuses on the optimization of the production process of two formulations composed of different surfactants produced by High Shear Homogenization followed by hot High Pressure Homogenization. To build up the surface response charts, a 2 full factorial design experiment, based on 2 independent variables, was used to develop optimized formulations. The effects of the production process on the mean particle size and polydispersity index were evaluated. The best ibuprofen nanocrystal formulations were obtained using 0.20% Tween 80 and 1.20% PVP K30 (F1) and 0.20% Tween 80 and 1.20% Span 80 (F2). The estimation of the long-term stability of the aqueous suspensions of ibuprofen nanocrystals was studied using the LUMISizer. The calculated instability index suggests that F1 was more stable when stored at 4 °C and 22 °C, whereas F2 was shown to be more stable when freshly prepared.

show abstract

Mesoporous silica sub-micron spheres as drug dissolution enhancers: Influence of drug and matrix chemistry on functionality and stability

Cited by 8 publications

References 42 publications

Archives of Metallurgy and Materials

Archives of Metallurgy and Materials

Thermodynamics of binary gas adsorption in nanopores

Ibuprofen nanocrystals developed by 22 factorial design experiment: A new approach for poorly water-soluble drugs

Contact Info

Product

Resources

About