Mesoporous Silica Nanospheres Functionalized by Tio2 as a Photoactive Antibacterial Agent

Cendrowski, Krzysztof; Perużyńska, Magdalena; Markowska‐Szczupak, Agata; Chen, Xuecheng; Wajda, Anna; Łapczuk, Joanna; Kurzawski, Mateusz; Kaleńczuk, Ryszard J.; Droździk, Marek; Mijowska, Ewa

doi:10.4172/2157-7439.1000182

Cited by 20 publications

(24 citation statements)

References 27 publications

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“…The erosion of mesoporous silica nanosphere structure modified with titanium dioxide was also observed in contact with Streptomyces cells. After 24-h incubation, mesoporous silica shell structure was degraded with simultaneous appearance of agglomerates, which clearly demonstrated that nanomaterial structure and composition could be affected by living cells [63].…”

Section: Cytotoxicitymentioning

confidence: 98%

General Cytotoxicity and Its Application in Nanomaterial Analysis

Jędrzejczak-Silicka¹,

Mijowska²

2018

Cytotoxicity

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The recent increasing interest in the use of different nanoparticles in biological and medical applications encouraged scientists to analyse their potential impact on biological systems. The biocompatibility analyses of novel materials for medical applications are conducted using quantitative and qualitative techniques collected by the International Standards Organization (ISO). The well-known assays, such as tetrazolium-based assays used for mitochondrial function monitoring, LDH for membrane permeability determination and neutral red uptake (NRU) describing lysosome function, need to be optimised due to specific properties of wide range of nanomaterials. Physicochemical properties of nanoparticles (NPs) such as size, composition, concentration, shape and surface (e.g., charge, coating, aspect ratio), as well as the cell type play a crucial role in determining the nanomaterial toxicity (also uptake pathway(s) of NPs). Different nanomaterials exhibit different cytotoxicity from relatively non-toxic hexagonal boron nitride to rutile TiO 2 NPs that induce oxidative DNA damage in the absence of UV light. Finally, the results of the nanomedical analysis can be enriched by holographic microscopy that gives valuable information about the doubling time (DT), cell segmentation, track cell movement and changes in cell morphology. The results can be also completed by phenotype microarrays (PMs) and atomic force microscopy (AFM) techniques that fulfil experimental data.

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Section: Cytotoxicitymentioning

confidence: 98%

General Cytotoxicity and Its Application in Nanomaterial Analysis

Jędrzejczak-Silicka¹,

Mijowska²

2018

Cytotoxicity

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“…Mijowska and co-workers prepared MS NPs functionalized by TiO 2 using the titania precursor titanium(IV) butoxide as a photoactive antibacterial agent. [272] The antibacterial effects of the TiO 2 -containing MS on E. coli after 24 h was evaluated by CFU. The assay showed strong enhancement upon visible and ultraviolet light irradiation compared with commercial TiO 2 .…”

Section: Ms With Metal-based Npsmentioning

confidence: 99%

“…Mijowska and co‐workers prepared MS NPs functionalized by TiO 2 using the titania precursor titanium(IV) butoxide as a photoactive antibacterial agent . The antibacterial effects of the TiO 2 ‐containing MS on E. coli after 24 h was evaluated by CFU.…”

Section: Ms In Antibacterial Applicationsmentioning

confidence: 99%

Mesoporous Silica‐Based Materials with Bactericidal Properties

Bernardos

Piacenza

Sancenón

et al. 2019

Small

136

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Bacterial infections are the main cause of chronic infections and even mortality. In fact, due to extensive use of antibiotics and, then, emergence of antibiotic resistance, treatment of such infections by conventional antibiotics has become a major concern worldwide. One of the promising strategies to treat infection diseases is the use of nanomaterials. Among them, mesoporous silica materials (MSMs) have attracted burgeoning attention due to high surface area, tunable pore/particle size, and easy surface functionalization. This review discusses how one can exploit capacities of MSMs to design and fabricate multifunctional/controllable drug delivery systems (DDSs) to combat bacterial infections. At first, the emergency of bacterial and biofilm resistance toward conventional antimicrobials is described and then how nanoparticles exert their toxic effects upon pathogenic cells is discussed. Next, the main aspects of MSMs (e.g., physicochemical properties, multifunctionality, and biosafety) which one should consider in the design of MSM‐based DDSs against bacterial infections are introduced. Finally, a comprehensive analysis of all the papers published dealing with the use of MSMs for delivery of antibacterial chemicals (antimicrobial agents functionalized/adsorbed on mesoporous silica (MS), MS‐loaded with antimicrobial agents, gated MS‐loaded with antimicrobial agents, MS with metal‐based nanoparticles, and MS‐loaded with metal ions) is provided.

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“…Due to the high WRC of TiO 2 /Perlite system, the saturation of the catalyst surface with water vapor molecules could be present. Also, it has been reported that TiO 2 is highly hydrophilic and easy to supersaturate with H 2 O molecules which could contribute to its inactivation and thus, affect its performance in the production of $OH radicals (Cendrowski et al, 2013;Rodrigues-Silva et al, 2017). Also, the saturation of the catalyst surface with reduced species of CO 2 emitted from the biofilter could be present Lingampalli et al, 2017).…”

Section: Effect Of the Supporting Materials On The Photocatalytic Actimentioning

confidence: 99%