Mesoporous Silica Nanoparticles for Drug Delivery

Manzano, Miguel; Vallet‐Regí, María

doi:10.1002/adfm.201902634

Cited by 677 publications

(430 citation statements)

References 162 publications

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“…For instance, it has been shown in vivo that the larger the nanoparticles the faster their excretion [84]. In addition, it has been observed that, unlike spherical particles, those presenting elongated or cylindrical shapes undergo faster clearance from the bloodstream [85]. Finally, the surface charge is a key parameter since it determines the interaction of the particles with the surrounding media.…”

Section: Biodistribution and Biodegradation Of Mesoporous Silica Nanomentioning

confidence: 99%

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Mesoporous Silica Nanoparticles for the Treatment of Complex Bone Diseases: Bone Cancer, Bone Infection and Osteoporosis

2020

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Bone diseases, such as bone cancer, bone infection and osteoporosis, constitute a major issue for modern societies as a consequence of their progressive ageing. Even though these pathologies can be currently treated in the clinic, some of those treatments present drawbacks that may lead to severe complications. For instance, chemotherapy lacks great tumor tissue selectivity, affecting healthy and diseased tissues. In addition, the inappropriate use of antimicrobials is leading to the appearance of drug-resistant bacteria and persistent biofilms, rendering current antibiotics useless. Furthermore, current antiosteoporotic treatments present many side effects as a consequence of their poor bioavailability and the need to use higher doses. In view of the existing evidence, the encapsulation and selective delivery to the diseased tissues of the different therapeutic compounds seem highly convenient. In this sense, silica-based mesoporous nanoparticles offer great loading capacity within their pores, the possibility of modifying the surface to target the particles to the malignant areas and great biocompatibility. This manuscript is intended to be a comprehensive review of the available literature on complex bone diseases treated with silica-based mesoporous nanoparticles—the further development of which and eventual translation into the clinic could bring significant benefits for our future society.

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Section: Biodistribution and Biodegradation Of Mesoporous Silica Nanomentioning

confidence: 99%

“…The dissolution rate depends on the particular characteristics of the particles and can be tuned through the introduction of organic modifications on the surface. Those modifications have been shown not to affect the biodistribution and biocompatibility of the MSNs [85].…”

Section: Biodistribution and Biodegradation Of Mesoporous Silica Nanomentioning

confidence: 99%

Mesoporous Silica Nanoparticles for the Treatment of Complex Bone Diseases: Bone Cancer, Bone Infection and Osteoporosis

2020

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“…Moreover, to combine great mechanical strength and excellent bioactivity of BGs, they can be successfully used as coatings on inert substrates [82]. Reaction to the physiological fluids and the formation of chemical bonding between bones and bioglass can be occurred when bioglasses are implanted in the body [83][84][85][86][87]. A bioactive surface can be considered as important agent to avoid many simultaneous reactions, which take place between the implant and the targeted tissue at the implant surface [82].…”

Section: Bioactive Glass In Biomedical Applicationsmentioning

confidence: 99%

Bioactive Glass Coated Zirconia for Dental Implants: a review

Zhang

2020

jcc

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Nowadays, zirconia has got extensive attention for dental implants, although it has disadvantages such as poor mechanical properties and brittleness that makes it unsuitable. On the other hand, bioactive glasses coating have been utilized on tougher substrates such as zirconia. Bioactive glass coatings can decrease the healing time and hence accelerate the formation of the bond between bone and implant. Hence in this study, we introduce the novel zirconia/bioactive glass composites with high mechanical strength and bioactivity to achieve the ideal implant dentistry. Furthermore, a review of bioactive glass coatings (i.e., 45S5 and 58S) on zirconia as well as surface modification methods (i.e., sol-gel, laser cladding, plasma spraying, etc.) is provided.

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“…PMONPs are synthesized from trialkoxypolysilylated organic precursors and usually silica sources are not used for their preparation. PMONPs possess improved properties compared to Mesoporous Silica Nanoparticles (MSN), which have been considerably reported for their nanomedicine applications [5][6][7][8][9][10][11][12]. Indeed, PMONPs can be loaded with hydrophobic or hydrophilic molecules and present better hemolytic properties than MSN [13,14].…”

Section: Introductionmentioning

confidence: 99%

Periodic Mesoporous Organosilica Nanoparticles with BOC Group, towards HIFU Responsive Agents

Li¹,

Gascó

Delalande

et al. 2020

Molecules

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Periodic Mesoporous Organosilica Nanoparticles (PMONPs) are nanoparticles of high interest for nanomedicine applications. These nanoparticles are not composed of silica (SiO2). They belong to hybrid organic–inorganic systems. We considered using these nanoparticles for CO2 release as a contrast agent for High Intensity Focused Ultrasounds (HIFU). Three molecules (P1–P3) possessing two to four triethoxysilyl groups were synthesized through click chemistry. These molecules possess a tert-butoxycarbonyl (BOC) group whose cleavage in water at 90–100 °C releases CO2. Bis(triethoxysilyl)ethylene E was mixed with the molecules Pn (or not for P3) at a proportion of 90/10 to 75/25, and the polymerization triggered by the sol-gel procedure led to PMONPs. PMONPs were characterized by different techniques, and nanorods of 200–300 nm were obtained. These nanorods were porous at a proportion of 90/10, but non-porous at 75/25. Alternatively, molecules P3 alone led to mesoporous nanoparticles of 100 nm diameter. The BOC group was stable, but it was cleaved at pH 1 in boiling water. Molecules possessing a BOC group were successfully used for the preparation of nanoparticles for CO2 release. The BOC group was stable and we did not observe release of CO2 under HIFU at lysosomal pH of 5.5. The pH needed to be adjusted to 1 in boiling water to cleave the BOC group. Nevertheless, the concept is interesting for HIFU theranostic agents.

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Mesoporous Silica Nanoparticles for Drug Delivery

Cited by 677 publications

References 162 publications

Mesoporous Silica Nanoparticles for the Treatment of Complex Bone Diseases: Bone Cancer, Bone Infection and Osteoporosis

Mesoporous Silica Nanoparticles for the Treatment of Complex Bone Diseases: Bone Cancer, Bone Infection and Osteoporosis

Bioactive Glass Coated Zirconia for Dental Implants: a review

Periodic Mesoporous Organosilica Nanoparticles with BOC Group, towards HIFU Responsive Agents

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