Mesoporous silica nanoparticles capped with graphene quantum dots as multifunctional drug carriers for photo-thermal and redox-responsive release

Gao, Yan; Zhong, Shuangling; Xu, Lifeng; He, Shihao; Dou, Yueming; Zhao, Shengnan; Chen, Peng; Cui, Xuejun

doi:10.1016/j.micromeso.2018.11.030

Cited by 45 publications

(22 citation statements)

References 48 publications

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“…While developing new nanomaterials, new drug delivery-release modes have also been explored. Generally, there are enhanced permeability and retention (EPR)-pH delivery-release mode [184], ligand-pH delivery-release mode [99,185,186], EPR-Photothermal Delivery-Release Mode [123], and Core/Shell-photothermal/magnetic thermal delivery-release mode [187,188]. In addition, other delivery-release modes are generally used to treat non-tumor diseases.…”

Section: Applications Of Gqds In Drug Deliverymentioning

confidence: 99%

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Synthesis of graphene quantum dots and their applications in drug delivery

et al. 2020

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This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.

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Section: Applications Of Gqds In Drug Deliverymentioning

confidence: 99%

“…Some researchers [187,188] have developed core-shell materials, which are generally combined with photodynamic therapy and thermodynamic therapy, providing new ideas for drug delivery and release.…”

Section: Core/shell-photothermal/magnetic Thermal Delivery-release Modementioning

confidence: 99%

Synthesis of graphene quantum dots and their applications in drug delivery

et al. 2020

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“…NCs with a size of about 100 nm have an excellent photothermal ability, originating from the GRQDs. In addition, the NCs had an interesting redox reaction to glutathione from disulfide bridges (created by an amino functionalized MSNs amidation cystine), and thus, the loaded drugs could be released in a controllable manner [138]. Cancer cells excrete lactic acid, which leads to low pH values in cancerous environments.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Graphenic Materials for Biomedical Applications

2019

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Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017-2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

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“…The removal of CTAB as a soft template results in the porous structure of silica layer. N 2 adsorption‐desorption isothrem of Fe 5 C 2 @pSiO 2 NPs (Figure ) exhibits a type‐IV curve for such mesoporous materials . The mesoporous size distribution curve (inset of Figure ) demonstrates that Fe 5 C 2 @pSiO 2 NPs have a bimodal pore size distribution where one mesopore is at 2.6 nm and the other is at 14.6 nm with a BJH (Barret‐Joyner‐Halenda).…”

Section: Resultsmentioning

confidence: 96%

Porous versus Dense ‐ Effect of Silica Coating on Contrast Enhancement of Iron Carbide Nanoparticles in T₂‐Weighted Magnetic Resonance Imaging

2020

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Magnetic nanoparticles development is an intense subject in various biomedical applications. Among these applications, magnetic nanoparticles as contrast agents are of special interest for improving the diagnostic accuracy of magnetic resonance imaging (MRI). We report here the synthesis of magnetic iron carbide nanoparticles and their stabilization in aqueous media. The challenge of achieving phase transfer of hydrophobic iron carbide nanoparticles to hydrophilic media was addressed by silica shell. Silica coated iron carbide nanoparticles were fabricated with both mesoporous and dense silica shells followed by investigating the impact of such a coating on their performance as T 2 -negative contrast agents in MRI. The crystalline structure of silica coated iron carbide nanoparticles was confirmed via X-ray diffraction (XRD) analysis.Fourier transform infrared spectroscopy (FTIR) demonstrated formation of the silica coating and transmission electron microscopy (TEM) confirmed the core@shell morphology of silica coated iron carbide nanoparticles. Mesoporous and dense silica coated iron carbide nanoparticles exhibited high transverse relaxivity values of 457 and 365 mM À 1 s À 1 , respectively. The enhanced MRI efficiency obtained from the silica coated iron carbide nanoparticles highlights these core@shell structures as promising negative contrast agents. Based on the results, the nature of silica coating both in porous or dense forms has a significant effect on water relaxivity which makes the iron carbide@mesoporous silica nanoparticles highly efficient T 2 contrast agents.

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Mesoporous silica nanoparticles capped with graphene quantum dots as multifunctional drug carriers for photo-thermal and redox-responsive release

Cited by 45 publications

References 48 publications

Synthesis of graphene quantum dots and their applications in drug delivery

Synthesis of graphene quantum dots and their applications in drug delivery

Graphenic Materials for Biomedical Applications

Porous versus Dense ‐ Effect of Silica Coating on Contrast Enhancement of Iron Carbide Nanoparticles in T₂‐Weighted Magnetic Resonance Imaging

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Mesoporous silica nanoparticles capped with graphene quantum dots as multifunctional drug carriers for photo-thermal and redox-responsive release

Cited by 45 publications

References 48 publications

Synthesis of graphene quantum dots and their applications in drug delivery

Synthesis of graphene quantum dots and their applications in drug delivery

Graphenic Materials for Biomedical Applications

Porous versus Dense ‐ Effect of Silica Coating on Contrast Enhancement of Iron Carbide Nanoparticles in T2‐Weighted Magnetic Resonance Imaging

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Product

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Porous versus Dense ‐ Effect of Silica Coating on Contrast Enhancement of Iron Carbide Nanoparticles in T₂‐Weighted Magnetic Resonance Imaging