Mesoporous Silica Nanoparticles‐Based Nanoplatforms: Basic Construction, Current State, and Emerging Applications in Anticancer Therapeutics

Abstract

In recent years, researchers are developing novel nanoparticles for diagnostic applications using imaging techniques and for therapeutic purposes through drug delivery techniques. The unique physical and chemical properties of mesoporous silica nanoparticles (MSNs) make it possible to integrate a variety of commonly used therapeutic and imaging agents to construct a multimodal synergistic anticancer drug delivery system. Herein, recent advances in MSNs synthesis for drug delivery and smart response applications are reviewed. First, synthetic strategies for the fabrication of ordered MSNs, hollow MSNs, core-shell structured MSNs, dendritic MSNs, and biodegradable MSNs are outlined. Then, the recent research progress in designing functional MSN materials with various controlled release mechanisms in anticancer therapy is discussed, and new properties are introduced to suggest the latest design requirements as drug delivery materials. The review also highlights significant achievements in bioimaging using MSNs and their multifunctional counterparts as delivery vehicles. Finally, personal views on key directions for future work in this area are presented.

WITHDRAWN: Polypeptide-coated 5-FU/ICG co-delivery vehicle MSNs for cancer treatment with chemo/photothermal/photodynamic simultaneous therapy

“…Various nanomaterials, such as hydrogels and nanoparticles, as nanodrug-delivery systems, have been thoroughly studied in the treatment of tumor animal models, and good therapeutic effects have been achieved [27][28][29][30][31] . Among the various nanomaterials mentioned above, mesoporous silica nanoparticles (MSNs), as a multifunctional nanoplatforms, exhibit excellent performance in cancer diagnosis and therapy [32][33][34] . MSNs have versatile loading capacity for various exogenous organic molecules, biological macromolecules, and even nanoparticles, due to their adjustable pore size and porosity, large surface area and customized surface functionalization [35][36] .…”

Nanoparticle-based delivery systems as emerging therapy in retinoblastoma: recent advances, challenges and prospects

“…Mesoporous silica nanoparticles (MSNs) stand out among various nanoparticle systems due to their enormous surface area, nano-sized particles, surface modications, tunable pore size, and pore shape. 83,84 They also exhibit exceptional colloidal stability. Due to their unique characteristics, including biocompatibility, MSNs have been investigated as a potential therapy for retinoblastoma.…”

“…Due to their unique characteristics, including biocompatibility, MSNs have been investigated as a potential therapy for retinoblastoma. 84,85 One method of employing MSNs in treating retinoblastoma entails dosing them with a chemotherapeutic agent and directing them, particularly to cancer cells in the eye. MSNs' large surface areas, variable pore sizes, and capacity to be functionalized with targeting ligands make it possible for them to load medicines efficiently and bind to cancer cells specically, as shown in Fig.…”

New insights into nanosystems for non-small-cell lung cancer: diagnosis and treatment

“…6C) usually possess a diameter ranging from 50 nm to 200 nm with tightly packed mesopores of size in a range of 3-4 nm. [97][98][99] MSNs are composed of silicon dioxide and are used widely in applications including synthetic processes, medical diagnosis, and therapy due to their high surface area, tuneable pore size, huge loading capacity, and tailored mesoporous structure. Moreover, the outward surface can be functionalized with ''molecular gates", permitting cargo delivery to be triggered by external stimuli such as specic pH, enzymes, and lasers of peculiar wavelengths.…”