Mesoporous silica nanoparticles as carrier to overcome bacterial drug resistant barriers

Zhuang, Jie; Yu, Yang; Li, Rui

doi:10.1016/j.ijpharm.2022.122529

Cited by 15 publications

(10 citation statements)

References 106 publications

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“…Although there are a wide variety of metal-based systems [111] (especially based on copper [112] and silver complexes [113]) that have been used in antibacterial studies, this part of the present review will focus on the use of silica-based materials as the support of metal complexes or other metal species as new therapeutic agents against bacteria. There is a very recent review covering the use of MSN-based systems in this field [114], however, covering only the ways of functionalization of MSN but not the use of different metallodrugs.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective

Díaz-García

Prashar

Gómez‐Ruiz

2023

IJMS

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Since the pioneering work of Vallet-Regí’s group on the design and synthesis of mesoporous silica-based materials with therapeutic applications, during the last 15 years, the potential use of mesoporous silica nanostructured materials as drug delivery vehicles has been extensively explored. The versatility of these materials allows the design of a wide variety of platforms that can incorporate numerous agents of interest (fluorophores, proteins, drugs, etc.) in a single scaffold. However, the use of these systems loaded with metallodrugs as cytotoxic agents against different diseases and with distinct therapeutic targets has been studied to a much lesser extent. This review will focus on the work carried out in this field, highlighting both the pioneering and recent contributions of Spanish groups that have synthesized a wide variety of systems based on titanium, tin, ruthenium, copper and silver complexes supported onto nanostructured silica. In addition, this article will also discuss the importance of the structural features of the systems for evaluating and modulating their therapeutic properties. Finally, the most interesting results obtained in the study of the potential therapeutic application of these metallodrug-functionalized silica-based materials against cancer and bacteria will be described, paying special attention to preclinical trials in vivo.

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Section: Antibacterial Activitymentioning

confidence: 99%

Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective

Díaz-García

Prashar

Gómez‐Ruiz

2023

IJMS

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“…Mesoporous silica nanoparticles (MSNs) are extensively studied as nanocargoes due to their remarkable biocompatibility, large drug-loading capacity, and customizable physicochemical properties [ 182 ]. Li et al [ 183 ] demonstrated that MSNs with a diameter below 100 nm effectively infiltrate dentin tubules, showcasing potential for delivering antimicrobial and mineralization agents in endodontic sealers.…”

Section: Nanomaterials As Endodontic Sealersmentioning

confidence: 99%

Application of Nanomaterials in Endodontics

Afkhami,

Chen,

Walsh

et al. 2024

BME Front

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Recent advancements in nanotechnology have introduced a myriad of potential applications in dentistry, with nanomaterials playing an increasing role in endodontics. These nanomaterials exhibit distinctive mechanical and chemical properties, rendering them suitable for various dental applications in endodontics, including obturating materials, sealers, retro-filling agents, and root-repair materials. Certain nanomaterials demonstrate versatile functionalities in endodontics, such as antimicrobial properties that bolster the eradication of bacteria within root canals during endodontic procedures. Moreover, they offer promise in drug delivery, facilitating targeted and controlled release of therapeutic agents to enhance tissue regeneration and repair, which can be used for endodontic tissue repair or regeneration. This review outlines the diverse applications of nanomaterials in endodontics, encompassing endodontic medicaments, irrigants, obturating materials, sealers, retro-filling agents, root-repair materials, as well as pulpal repair and regeneration. The integration of nanomaterials into endodontics stands poised to revolutionize treatment methodologies, presenting substantial potential advancements in the field. Our review aims to provide guidance for the effective translation of nanotechnologies into endodontic practice, serving as an invaluable resource for researchers, clinicians, and professionals in the fields of materials science and dentistry.

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“…Over the last 20 years, organically modified mesoporous silica nanoparticles (MSNs) have been extensively exploited as drug delivery systems for a wide range of biomedical applications, − most recently including the treatment of bacterial infections. − MSNs constitute excellent nanocarriers due to their unique features, including large loading capacity, biocompatibility, ease of manufacture, adjustable pore sizes and volumes, and high density of silanol groups on their surface, that could favor subsequent functionalization processes. , …”

Section: Introductionmentioning

confidence: 99%

Organically Modified Mesoporous Silica Nanoparticles against Bacterial Resistance

Colilla,

Vallet-Regí

2023

Chem. Mater.

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Bacterial antimicrobial resistance is posed to become a major hazard to global health in the 21st century. An aggravating issue is the stalled antibiotic research pipeline, which requires the development of new therapeutic strategies to combat antibiotic-resistant infections. Nanotechnology has entered into this scenario bringing up the opportunity to use nanocarriers capable of transporting and delivering antimicrobials to the target site, overcoming bacterial resistant barriers. Among them, mesoporous silica nanoparticles (MSNs) are receiving growing attention due to their unique features, including large drug loading capacity, biocompatibility, tunable pore sizes and volumes, and functionalizable silanol-rich surface. This perspective article outlines the recent research advances in the design and development of organically modified MSNs to fight bacterial infections. First, a brief introduction to the different mechanisms of bacterial resistance is presented. Then, we review the recent scientific approaches to engineer multifunctional MSNs conceived as an assembly of inorganic and organic building blocks, against bacterial resistance. These elements include specific ligands to target planktonic bacteria, intracellular bacteria, or bacterial biofilm; stimuli-responsive entities to prevent antimicrobial cargo release before arriving at the target; imaging agents for diagnosis; additional constituents for synergistic combination antimicrobial therapies; and aims to improve the therapeutic outcomes. Finally, this manuscript addresses the current challenges and future perspectives on this hot research area.

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Mesoporous silica nanoparticles as carrier to overcome bacterial drug resistant barriers

Cited by 15 publications

References 106 publications

Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective

Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective

Application of Nanomaterials in Endodontics

Organically Modified Mesoporous Silica Nanoparticles against Bacterial Resistance

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