Mesoporous Silica Nanoparticles as a System for Ciprofloxacin Drug Delivery; Kinetic of Adsorption and Releasing

Abstract

Mesoporous silica (MPS) nanoparticle was prepared as carriers for drug delivery systems by sol-gel method from sodium silicate as inexpensive precursor of silica and Cocamidopropyl betaine (CABP) as template. The silica particles were characterized by SEM, TEM, AFM, XRD, and N2adsorption-desorption isotherms. The results show that the MPS particle in the nanorange (40-80 nm) with average diameter equal to 62.15 nm has rods particle morphology, specific surface area is 1096.122 m 2 /g, pore volume 0.900 cm 3 /g, with average pore diameter 2.902 nm, which can serve as efficient carriers for drugs. The adsorption kinetic of Ciprofloxacin (CIP) drug was studied and the data were analyzed and found to match well with pseudofirst order kinetic model. The CIP drug-loaded mesoporous silica (CIP-mSiO2) nanoparticles has capacity of about 16.3 mg drug/ mg mSiO 2 were achieved, and capable of releasing 26% and 98.6% of their drug content after 90 min in water and PBS solution(pH,7.4) respectively. In-vitro controlled release studies of CIP in Simulated Body Fluid were carried out under stirring conditions. A study on release kinetics and mechanism using Koresmeyer-Pepps model, first order kinetic, and kopcha model shows that the Korsmeyer-Peppas and Kopcha models, both conform more closely to the release data.

الايزوثيرمات والدوال الدينميكية الحرارية لامتزاز دواء الميتوبرولول على السليكا متوسطة المسام المحضرة

“…Adsorbent: Using sodium silicate (14% NaOH, 27% SiO2 w/w) as a source of silica and hydroxycetyl hydroxy ethyl dimonium chloride (dehyquart) surfactant as a template, both of which were obtained from the state company of vegetable oils in Iraq, the process for making mesoporous silica as an adsorbent is similar to the one we reported earlier 9 .…”

Synthesis, Structure and Biological Activity Studies of New Metal Ion Complexes Based on 3-[(3-Hydroxynaphthalene-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one

“…It should be noted that the lack of the C=O absorption band of 2-hydroxynaphthaldehyde might potentially assist ligand synthesis via this group. Other absorption bands were found at 1712, 3201, and 3417 cm −1 , which correspond to the stretching vibrational modes of the following functional groups: C=O of amide, N-H amine, and O-H hydroxyl, respectively [19]. When the infrared spectra of the complexes were compared to the spectrum of the ligand, a considerable change was discovered as bands vanished or moved to other frequencies, and new bands were developed that were not present in the L ligand spectrum.…”

“…The ligand's electronic spectra displayed significant absorption at 305, 344, and 437 nm that are related to π→π * , n→π * , and charge transfer (CT), respectively [21]. Changes in the placement of absorption bands in the complex spectra were detected, indicating metal ion coordination via the azomethine and oxygen functional groups [19][20]. The Co(II) complex spectrum showed four bands at 385, 527, 705, and 931 nm, which represented the permitted transitions and had a magnetic moment of 4.79 MB.…”

Surface Modification of Mesoporous Silica Nanoparticles for Application in Targeted Delivery Systems of Antitumour Drugs

“…Mesoporous silica nanoparticles are promising nanoscale carriers due to the ease with which they can be synthesized and their homogeneous structure, tuneable size (50–200 nm) [ 67 ], and large pore volume (0.6–1.4 cm 3 /g) [ 68 , 69 ]. With a high specific surface area (700–1000 m 2 /g) [ 70 , 71 ], MSNs have high drug loading capacity.…”