Mesoporous silica MCM-41 and HMS as advanced drug delivery carriers for bicalutamide

A novel BMSN (biologically synthesized mesoporous silica nanoparticles) material: synthesis using a bacteria-mediated biosurfactant and characterization

“…Furthermore, the wide-angle XRD-diffraction peaks of synthesized material were found to be comparable to those of chemical surfactant-based MMs. 29 However, the low-angle XRD showed diffraction peaks with very low diffraction angles ( Fig. 1a–d ) as compared to the organic surfactant-based materials, where the decrease of diffraction angle could be dependent upon the amount of silica in the materials.…”

“…450 C, 500 C, 550 C, and 600 C) were found to be almost the same, which is similar to the ndings of Wu et al 28 The unit cell diameter of BMSN was observed to be higher (unit cell diameter 62.18 A) than the chemical surfactant-based synthesized material (unit cell diameter < 50 A) owing to efficient collaboration between the precursor and the biosurfactants. 5,29 The phase composition and crystallinity of the synthesized materials (BMSN) were determined using wideangle XRD (Fig. 1b).…”

Mesoporous silica nanoparticles: Synthesis, functionalization, drug loading and release - A review

“…They have large surface areas, extensive pore volumes and narrow distribution of adjustable pore diameters, thanks to their specific structure [1]. The MSNs can be used to develop systems for controlled drug delivery which ensures the sustained release of drugs by maintaining their therapeutic concentrations at the target areas for an extended period, leading to reduction in frequencies of doses and the possibility of side effects [3,4]. These systems can also solve the problem of poor aqueous solubility of drugs by loading them into the mesoporous silica nanoparticle pores.…”

Egg-yolk core–shell mesoporous silica nanoparticles for high doxorubicin loading and delivery to prostate cancer cells

“…[22][23][24][25] Therefore, extensive studies have been conducted on the synthesis of MSNs with tunable pore sizes and surface areas and their application in the delivery of various chemotherapeutic drugs to the PCa. [26][27][28][29][30][31][32] MSNs are also being extensively used for the delivery of proteins such as cytochrome-c, amino acids, vitamins, lysozyme and heme proteins. [33][34][35][36][37][38][39][40][41][42] For example, eccentric mesoporous silica nanoclusters have been designed for pH-responsive Dox delivery accompanied by sustained drug release.…”

“…22–25 Therefore, extensive studies have been conducted on the synthesis of MSNs with tunable pore sizes and surface areas and their application in the delivery of various chemotherapeutic drugs to the PCa. 26–32 MSNs are also being extensively used for the delivery of proteins such as cytochrome-c, amino acids, vitamins, lysozyme and heme proteins. 33–42…”